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    Academic Journals

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• Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomach

  Authors:Smita Raghuvanshi and Kamla PathakFrom:Journal of Drug DeliveryPeer-Reviewed

  Annual 201411,082 words Report 1420LLow solubility causing low dissolution in gastrointestinal tract is the major problem for drugs meant for systemic action after oral administration, like cinnarizine. Pharmaceutical products of cinnarizine are...

• Addiction: Piperazine as a drug of misuse

  From:The PractitionerPeer-Reviewed

  Oct. 25, 2007353 words Brief article 1170LDr Jez Thompson Former GP, Clinical Director, Leeds Community Drug Services I was surprised when I first heard of piperazine being used as a recreational drug, having previously known it solely as an antihelminthic....

• Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives

  Authors:Betul Kaya, Yusuf Ozkay, Halide Edip Temel, and Zafer Asim KaplancikliFrom:Journal of Chemistry (Vol. 2016) Peer-Reviewed

  Annual 20164,623 words Report 1630LSome hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of...

• Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as CCR5 Antagonists

  Authors:Tao Liu, Zhiyong Weng, Xiaowu Dong, Linjie Chen, Ling Ma, Shan Cen, et al.From:PLoS ONE (Vol. 8, Issue 1) Peer-Reviewed

  Jan. 7, 20133,312 words Article 1440LBy using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and...

• Triazene derivatives of (1,x)-diazacycloalkanes. Part VIII. Synthesis and characterization of a series of 1,4-di[2-aryl-1-diazenyl]-2-methylpiperazines (1)

  Authors:Naomi Hunter, Reid Tingley, Brad Peori, and Keith VaughanFrom:Canadian Journal of Chemistry (Vol. 85, Issue 3) Peer-Reviewed

  Mar. 20074,773 words Article 1440LAbstract: A series of 1,4-di-[2-aryl-1-diazenyl]-2-methylpiperazines (4a-n) have been synthesized by the reaction of 2-methylpiperazine with 2 equiv. of the appropriate diazonium salt. The products have been...

• Analgesic and anti-inflammatory activities of certain 6-aryl-9-substituted-6,9-diazaspiro-[4,5]decane-8,10-diones in mice

  Authors:Mona Aboutabl and Walaa Abd El-HamidFrom:Egyptian Pharmaceutical Journal (Vol. 14, Issue 3) Peer-Reviewed

  September-December 20154,554 words Report 1700LByline: Mona. Aboutabl, Walaa. Abd El-Hamid Background and objective 2,6-Diketopiperazines are promising bioactive chemical entities in drug discovery. They could be considered a versatile template for the synthesis...

• An ayurvedic formulation Sankat Mochan: A potent anthelmintic medicine

  Authors:Khomendra Sarwa, Prabhat Vishwakarma, Vijendra Suryawanshi, Tilotma Sahu, Lokesh Kumar, and Jaya ShreeFrom:Drug Development and Therapeutics (Vol. 8, Issue 1) Peer-Reviewed

  January-June 20171,781 words Report 1530LByline: Khomendra. Sarwa, Prabhat. Vishwakarma, Vijendra. Suryawanshi, Tilotma. Sahu, Lokesh. Kumar, Jaya. Shree Aim and Object: Sankat Mochan is an ayurvedic formulation used in the urban and rural area of India....

• Virtual screening and biological evaluation of piperazine derivatives as human acetyl-cholinesterase inhibitors

  Authors:Kavitha Raj Varadaraju, Jajur Ramanna Kumar, Lingappa Mallesha, Archana Muruli, Kikkeri Narasimha Shetty Mohana, Chethan Kumar Mukunda, et al.From:International Journal of Alzheimer's DiseasePeer-Reviewed

  Annual 20134,932 words Report 1540LThe piperazine derivatives have been shown to inhibit human acetyl-cholinesterase. Virtual screening by molecular docking of piperazine derivatives 1-(1,4-benzodioxane-2-carbonyl) piperazine (K),...

• [beta]-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

  Authors:Zhiying Yu, Rui Wang, Liying Xu, Siwei Xie, Jinhua Dong, and Yongkui JingFrom:PLoS ONE (Vol. 6, Issue 1) Peer-Reviewed

  Jan. 25, 20117,208 words Article 1410L[beta]-Elemene is an active component of the herb medicine Curcuma Wenyujin with reported antitumor activity. To improve its antitumor ability, five novel piperazine derivatives of [beta]-elemene,...

• Piperazine side-effects in a patient with pre-existing renal insufficiency

  Author:Majid MalakiFrom:Saudi Journal of Kidney Diseases and Transplantation (Vol. 25, Issue 2) Peer-Reviewed

  March-April 20141,032 words Clinical report 1620LByline: Majid. Malaki Piperazine as an antihelminth has many adverse effects, especially on patients with renal insufficiency. We report the use of piperazine in a girl with a moderately severe kidney disease due to...

• Synthesis of the Poly(phosphoric-boric acid) Piperazine and Its Application as an Effective Flame Retardant for Epoxy Resins

  Authors:Miao-Jun Xu, Kun Ma, Chuan Liu, and Bin LiFrom:Polymer Engineering and Science (Vol. 58, Issue 10) Peer-Reviewed

  Oct. 20186,250 words Report 1610LA novel phosphorus-nitrogen-boron containing flame retardant additive of poly(phosphoric-boric acid) piperazine, defined as PPBAP was synthesized by the salt-forming reaction between anhydrous piperazine and...

• Dissociative and sympathomimetic toxicity associated with recreational use of 1-(3-trifluoromethylphenyl) piperazine (TFMPP) and 1-benzylpiperzine (BZP)

  Authors:David M. Wood, Jenny Button, Satnam Lidder, John Ramsey, David W. Holt, and Paul I. DarganFrom:Journal of Medical Toxicology (Vol. 4, Issue 4) Peer-Reviewed

  Dec. 20082,471 words Case study ABSTRACT Introduction: There is emerging evidence of increasing use of legally available synthetic compounds as recreational drugs. While there are some changes to legislation relating to these synthetic compounds,...

• Unusual cerebellar ataxia: "worm wobble" revisited. (Case Report)

  Authors:R. Shroff and B. HoustonFrom:Archives of Disease in Childhood (Vol. 87, Issue 4) Peer-Reviewed

  Oct. 20021,049 words Article We present an unusual case of cerebellar ataxia in a 2 year old girl several days after treatment with piperazine citrate for suspected worm infestation. This is the first reported case of delayed onset neurotoxicity...

• Piperazine citrate induced myoclonus in a child

  Authors:T. Abiramalatha, Sumit Mehndiratta, Krishnan Rajeshwari, and Anand DubeyFrom:Indian Journal of Pharmacology (Vol. 45, Issue 6) Peer-Reviewed

  November-December 2013728 words Report 1400LByline: T. Abiramalatha, Sumit. Mehndiratta, Krishnan. Rajeshwari, Anand. Dubey Sir, Piperazine citrate is used as a vermifuge in pediatric practice. Various neurotoxic side effects of piperazine have been...

• Virtual screening and biological evaluation of piperazine derivatives as human acetylcholinesterase inhibitors

  Authors:Kavitha Raj Varadaraju, Jajur Ramanna Kumar, Lingappa Mallesha, Archana Muruli, Kikkeri Narasimha Shetty Mohana, Chethan Kumar Mukunda, et al.From:Interdisciplinary Perspectives on Infectious DiseasesPeer-Reviewed

  Annual 20134,933 words Report 1530LThe piperazine derivatives have been shown to inhibit human acetylcholinesterase. Virtual screening by molecular docking of piperazine derivatives 1-(1,4-benzodioxane-2-carbonyl) piperazine (K),...

• 2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors

  Authors:D. K. Nilov, K. I. Yashina, I. V. Gushchina, A. L. Zakharenko, M. V. Sukhanova, O. I. Lavrik, et al.From:Biochemistry (Moscow) (Vol. 83, Issue 2) Peer-Reviewed

  Feb. 20181,771 words Report 2550LWe show for the first time that natural 2,5-diketopiperazines (cyclic dipeptides) can suppress the activity of the important anticancer target poly(ADP-ribose)polymerase (PARP). Cyclo(L-Ala-L-Ala) and cyclo(L-Ala-D-Ala)...

• The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice

  Authors:Karolina Pytka, Elzbieta Zmudzka, Klaudia Lustyk, Anna Rapacz, Adrian Olczyk, Adam Galuszka, et al.From:Indian Journal of Pharmacology (Vol. 48, Issue 3) Peer-Reviewed

  May-June 20163,534 words Report 1410LByline: Karolina. Pytka, Elzbieta. Zmudzka, Klaudia. Lustyk, Anna. Rapacz, Adrian. Olczyk, Adam. Galuszka, Anna. Waszkielewicz, Henryk. Marona, Jacek. Sapa, Filipek. Barbara Objectives: Xanthones are flavonoids with...

• Effects of the Sigma-1 Receptor Agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-Phenylpropyl)-Piperazine Dihydro-Chloride on Inflammation after Stroke

  Authors:Karsten Ruscher, Ana R. Inacio, Kristian Valind, Arman Rowshan Ravan, Enida Kuric, and Tadeusz WielochFrom:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 18, 20126,138 words Article 1470LAuthor(s): Karsten Ruscher * , Ana R. Inácio, Kristian Valind, Arman Rowshan Ravan, Enida Kuric, Tadeusz Wieloch Introduction Stroke induces an inflammatory response, which includes the activation and accumulation...

• Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine

  Authors:Charles O. Nwuche, Oguejiofo T. Ujam, Akachukwu Ibezim, and Ifeoma B. UjamFrom:PLoS ONE (Vol. 12, Issue 1) Peer-Reviewed

  Jan. 20, 20174,688 words Report 1590LThe Antibiogram properties of 1-chloro-2-isocyanatoethane derivatives of thiomorpholine (CTC), piperazine (CPC) and morpholine (CMC) were evaluated by the approved agar well diffusion, the minimum inhibitory...

• Interventional role of piperazine citrate in barium chloride induced ventricular arrhythmias in anaesthetized rats

  Authors:S. Ghasi, A. Mbah, P. Nze, E. Nwobodo, A. Ogbonna, and G. OnuaguluchiFrom:Biomedical Research (Vol. 20, Issue 3) Peer-Reviewed

  September-December 20093,554 words Article Byline: S. Ghasi, A. Mbah, P. Nze, E. Nwobodo, A. Ogbonna, G. Onuaguluchi Interventional potential of piperazine in Barium Chloride (BC) -induced ventricular arrhythmias was investigated in the rats. Various forms of...