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• Irinotecan compared with etoposide in combination with platinum in previously untreated extensive stage small cell lung cancer: An updated systemic review

  Authors:Qinyong Hu, Qi Wang, Hengbo Zhu, Yi Yao, and Qibin SongFrom:Journal of Cancer Research and Therapeutics (Vol. 12, Issue 2) Peer-Reviewed

  April-June 20163,218 words Report 1350LByline: Qinyong. Hu, Qi. Wang, Hengbo. Zhu, Yi. Yao, Qibin. Song Objective: To compare the therapeutic effect of irinotecan/platinum (IP) and etoposide/platinum (EP) in treatment-naive extensive small cell lung...

• A solid-state [sup.17]O NMR study of platinum-carboxylate complexes: carboplatin and oxaliplatin

  Authors:Xianqi Kong, Victor Terskikh, Abouzar Toubaei, and Gang WuFrom:Canadian Journal of Chemistry (Vol. 93, Issue 9) Peer-Reviewed

  Sept. 20156,337 words Report 1600LWe report synthesis and solid-state NMR characterization of two [sup.17]O-labeled platinum anticancer drugs: cis-diammine(1,1cydobutane-[[sup.17][O.sub.4]]dicarboxylato)platinum(II) (carboplatin) and...

• Synthesis and evaluation of the in vitro DNA-binding properties of chiral cis-dichloro(pyridyloxazoline)platinum(II) complexes

  Authors:David W. Dodd, Heather E. Toews, Michael J. Trevail, Michael C. Jennings, Robert H.E. Hudson, and Nathan D. JonesFrom:Canadian Journal of Chemistry (Vol. 87, Issue 1) Peer-Reviewed

  Jan. 20094,983 words Report A series of chiral cis-dichloro(pyridyloxazoline) platinum(II) and palladium(II) complexes were synthesized and their reactivity towards a defined sequence of single-stranded and double-stranded DNA was investigated in...

• Biological effect and molecular docking of anticancer palladium and platinum complexes with morpholine dithiocarbamate on human serum albumin as a blood carrier protein

  Authors:Seyed Ali Hosseini, Mahboube Eslami Moghadam, Maryam Saeidifar, and Ali Akbar SabouryFrom:Canadian Journal of Physiology and Pharmacology (Vol. 96, Issue 12) Peer-Reviewed

  Dec. 20186,365 words Report 1500LThe aim of this study was to examine the interaction of [Pd (2,2'-bipyridine) (morpholinedithiocarbamate)] N[O.sub.3] and [Pt (2,2'-bipyridine)(morpholinedithiocarbamate)]N[O.sub.3] with human serum albumin under...

• Monometallic Pd and Pt and Bimetallic Pd-Pt/[Al.sub.2] [O.sub.3]-Ti[O.sub.2] for the HDS of DBT: effect of the Pd and Pt incorporation method

  Authors:Reynaldo Martinez Guerrero, Agileo Hernandez-Gordillo, Victor Santes, Jorge Roberto Vargas Garcia, Jose Escobar, Leonardo Diaz-Garcia, et al.From:Journal of Chemistry (Vol. 2014) Peer-Reviewed

  Annual 20146,140 words Report 1410LThe effect of the preparation method of monometallic Pd and Pt and bimetallic Pd-Pt/[Al.sub.2][O.sub.3]-Ti[O.sub.2] catalysts on the hydrodesulfurization (HDS) of dibenzothiophene (DBT) was investigated in this study....

• Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

  Authors:Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Q Yu, and Fazlul HuqFrom:Journal of Ovarian Research (Vol. 6, Issue 1) Peer-Reviewed

  Nov. 9, 20137,064 words Report 1640LBackground Ovarian cancer remains an on-going challenge mainly due to the development of drug resistance and also because the cancer is likely to have metastasized at the time of diagnosis. Currently, chemotherapy...

• Management of small-cell lung cancer: incremental changes but hope for the future

  Authors:Christine L. Hann and Charles RudinFrom:Oncology (Vol. 22, Issue 13) Peer-Reviewed

  Nov. 30, 20085,961 words Clinical report ABSTRACT Over 25,000 people are diagnosed with small-cell lung cancer (SCLC) in the United States annually. SCLC is a highly aggressive tumor with a propensity for early metastases and a high case-fatality rate....

• Comparison study of quality of life in advanced lung cancer patients on tyrosine kinase inhibitor and platinum doublet chemotherapy

  Authors:K. Udupa, R. Rajendranath, and T. SagarFrom:Indian Journal of Cancer (Vol. 54, Issue 1) Peer-Reviewed

  January-March 20171,380 words Report 1640LByline: K. Udupa, R. Rajendranath, T. Sagar INTRODUCTION: Lung cancer is most common cause of cancer death in the world. Most of the patient are diagnosed in the late stages and receive only palliative treatment. The...

• Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand

  Authors:Jerry D. Monroe, Heidi L. Hruska, Hannah K. Ruggles, Kevin M. Williams, and Michael E. SmithFrom:PLoS ONE (Vol. 13, Issue 3) Peer-Reviewed

  Mar. 7, 20188,600 words Report 1490LAuthor(s): Jerry D. Monroe 1, Heidi L. Hruska 2, Hannah K. Ruggles 2, Kevin M. Williams 2, Michael E. Smith 1,* Introduction A major side-effect of platinum-based anticancer drugs is damage to auditory hair cells...

• Rapid palliation of symptoms with platinum-based chemotherapy plus cetuximab in recurrent oral cancer: a case report

  Authors:Ricard Mesia, Ramon Palmero, Monica Cos, Esther Vilajosana, and Silvia VazquezFrom:Head & Neck Oncology (Vol. 2) Peer-Reviewed

  Jan. 27, 20103,104 words Case study Background Symptom control is an important consideration in the choice of treatment for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). Patients who demonstrate...

• Metal compounds in therapy and diagnosis

  Authors:Michael J. Abrams and Barry A. MurrerFrom:Science (Vol. 261, Issue 5122) Peer-Reviewed

  Aug. 6, 19934,971 words Cover story There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in...

• Predictive significance of inflammatory indexes in metastatic nonsmall cell lung cancer patients treated with platinum-doublet chemotherapy.

  Authors:Mesut Yilmaz, Ahmet Baran, and Merve YilmazFrom:Journal of Cancer Research and Therapeutics (Vol. 18, Issue 1) Peer-Reviewed

  Jan-March 20222,261 words Report 1750LByline: Mesut. Yilmaz, Ahmet. Baran, Merve. Yilmaz Introduction: Lung cancer is the leading cause of cancer-related deaths, worldwide. Despite immune checkpoint inhibitors and targeted therapy have revolutionized the...

• ATP7B rs9535826 is associated with gastrointestinal toxicity of platinum-based chemotherapy in nonsmall cell lung cancer patients

  Authors:Yue-Qin Li, Xin-Yin Zhang, Juan Chen, Ji-Ye Yin, and Xiang-Ping LiFrom:Journal of Cancer Research and Therapeutics (Vol. 14, Issue 4) Peer-Reviewed

  October-December 20183,205 words Report 1420LByline: Yue-Qin. Li, Xin-Yin. Zhang, Juan. Chen, Ji-Ye. Yin, Xiang-Ping. Li Aims: Platinum-based chemotherapy is considered as the first-line treatment for nonsmall cell lung cancer (NSCLC) patients. However,...

• The role of solvent in organometallic chemistry--oxidative addition with dichloromethane or chloroform

  Authors:Anwar Abo-Amer, Matthew S. McCready, Fenbao Zhang, and Richard J. PuddephattFrom:Canadian Journal of Chemistry (Vol. 90, Issue 1) Peer-Reviewed

  Jan. 20124,870 words Report 1610LDimethylplatinum(II) complexes [Pt[Me.sub.2](NN)], with NN = diimine ligand, can react with dichloromethane or chloroform solvent to give the corresponding organoplatinum(IV) complexes [PtCl[Me.sub.2](C[H.sub.2]Cl)(NN)]...

• ATP11B mediates platinum resistance in ovarian cancer

  Authors:Myrthala Moreno-Smith, J.B. Halder, Paul S. Meltzer, Tamas A. Gonda, Lingegowda S. Mangala, Rajesha Rupaimoole, et al.From:Journal of Clinical Investigation (Vol. 123, Issue 5) Peer-Reviewed

  May 20138,199 words Report 1310LPlatinum compounds display clinical activity against a wide variety of solid tumors; however, resistance to these agents is a major limitation in cancer therapy. Reduced platinum uptake and increased platinum export are...

• Synthesis, characterization, and bioactivities of platinum(II) complexes bearing pyridinecarboxaldimines containing aliphatic groups

  Authors:Erin L. Stewart, Alyssa E. Patterson, Taryn O'Neill, Haoxin Li, Andrew Flewelling, Christopher M. Vogels, et al.From:Canadian Journal of Chemistry (Vol. 91, Issue 2) Peer-Reviewed

  Feb. 20134,919 words Report 1630LCondensation of 2-pyridinecarboxaldehyde with six primary amines containing aliphatic groups gave the corresponding pyridinecarboxaldimines (N-N'R). Addition of these ligands to [Pt[Cl.sub.2](coe)]2 (coe =...

• Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes

  Authors:Pavel Starha, Jan Vanco, Zdenek Travnicek, Jan Hosek, Jarmila Klusakova, and Zdenek DvorakFrom:PLoS ONE (Vol. 11, Issue 12) Peer-Reviewed

  Dec. 1, 201612,464 words Report 1640LA series of platinum(II) diiodido complexes containing 7-azaindole derivatives, having the general formula cis-[PtI.sub.2 (naza).sub.2 ] (1-8), has been prepared and thoroughly characterized, including X-ray structure...

• Dinuclear organoplatinum(II) complexes containing N-methylbenzamide

  Authors:Michael G. Crisp and Louis M. RendinaFrom:Canadian Journal of Chemistry (Vol. 87, Issue 1) Peer-Reviewed

  Jan. 20093,104 words Report The preparation and characterization of cationic, dinuclear complexes of the type trans-[Pt[([PPh.sub.3]).sub.2] ([sigma]-[C.sub.6][H.sub.4]NHMe) -[mu]-L-Pt[([PPh.sub.3].sub.2]...

• A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

  Authors:Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, et al.From:Nature Medicine (Vol. 23, Issue 4) Peer-Reviewed

  Apr. 201711,466 words Report 1500LCisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in germ cell, breast and lung...

• Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-Azaindoles

  Authors:Pavel A tarha, ZdenAk Dvorak, and ZdenAk TravnicekFrom:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 26, 20159,891 words Report 1650LThe cis-[PtCl.sub.2 (naza).sub.2 ] complexes (1-3) containing monosubstituted 7-azaindole halogeno-derivatives (naza), showed significantly higher activity than cisplatin towards ovarian carcinoma A2780, its...