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From:Nature (Vol. 569, Issue 7758) Peer-ReviewedThe presence of a quaternary centre--a carbon with four other carbons bonded to it--in any given molecule can have a substantial chemical and biological impact. In many cases, it can enable otherwise challenging...
From:Nature (Vol. 580, Issue 7802) Peer-ReviewedMulticomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences.sup.1. Recently,...
From:Canadian Journal of Physiology and Pharmacology (Vol. 93, Issue 9) Peer-ReviewedA substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (m[K.sub.ATP]) in the heart is protective in conditions associated with ischemia/reperfusion...
From:Organic Chemistry InternationalPeer-ReviewedSubstituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles (6), 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (7), and 3-amino-1-aryl-1H-benzo[f]chromenes-2-carbonitriles (8) were prepared, in good yields,...
From:Journal of the Chemical Society of Pakistan (Vol. 35, Issue 4) Peer-ReviewedByline: AKBAR MOBINIKHALEDI AND MAHSA JABBARPOUR Summary: Chromene and spirocyclic 2-oxindole derivatives were readily synthesized in good yields via a one-pot three-component reaction involving Knoevenagel...
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