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• Physiological responses of Orthosiphon stamineus plantles to gamma irradiation

  Authors:Anna Ling Pick Kiong, Alvina Grace Lai, Sobri Hussein, and Abdul Rahim HarunFrom:American-Eurasian Journal of Sustainable AgriculturePeer-Reviewed

  May 20088,619 words Report In vitro mutagenesis by means of gamma irradiation can be used to produce economically improved mutants. Gamma irradiation was used to induce biochemical changes in a prominent medicinal plant, Orthosiphon stamineus....

• Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases

  Authors:Dominik A. Herbst, Roman P. Jakob, Franziska Zahringer, and Timm MaierFrom:Nature (Vol. 531, Issue 7595) Peer-Reviewed

  Mar. 24, 20168,430 words Report 1480LPolyketide synthases (PKSs) are biosynthetic factories that produce natural products with important biological and pharmacological activities (1-3). Their exceptional product diversity is encoded in a modular...

• Function of ORFC of the polyketide synthase gene cluster on fatty acid accumulation in Schizochytrium limacinum SR21.

  Authors:Yanyan Shi, Zhen Chen, Yixin Li, Xingyu Cao, Lijie Yang, Yiyuan Xu, et al.From:Biotechnology for Biofuels (Vol. 14, Issue 1) Peer-Reviewed

  July 23, 20217,158 words Report 1380LBackground As a potential source of polyunsaturated fatty acids (PUFA), Schizochytrium sp. has been widely used in industry for PUFA production. Polyketide synthase (PKS) cluster is supposed to be the primary way of...

• A formal synthesis of (+)-muricatacin from L-tartaric acid

  Authors:Jack M. Southard and Nicole L. SearsFrom:The Texas Journal of Science (Vol. 59, Issue 4) Peer-Reviewed

  Nov. 20071,013 words Report 1170LMuricatacin (1) is an acetogenin that displays cytotoxic activity towards certain tumor cell lines found in humans (Figure 1). This lipid-soluble class of anticancer drug was first isolated from the seeds of the Soursop...

• Metamorphic enzyme assembly in polyketide diversification

  Authors:Liangcai Gu, Bo Wang, Amol Kulkarni, Todd W. Geders, Rashel V. Grindberg, Lena Gerwick, et al.From:Nature (Vol. 459, Issue 7247) Peer-Reviewed

  June 4, 20093,800 words Report 1530LNatural product chemical diversity is fuelled by the emergence and ongoing evolution of biosynthetic pathways in secondary metabolism (1). However, co-evolution of enzymes for metabolic diversification is not well...

• Modular biosynthesis branches out

  Author:Craig A. TownsendFrom:Nature (Vol. 502, Issue 7469) Peer-Reviewed

  Oct. 20131,538 words Article 1510LRings in biologically active molecules confer rigidity that helps the molecules to bind strongly and selectively to their targets. A ring-forming mechanism has been identified that involves a biochemically unusual...

• Polyketide and nonribosomal peptide antibiotics: modularity and versatility

  Author:Christopher T. WalshFrom:Science (Vol. 303, Issue 5665) Peer-Reviewed

  Mar. 19, 20043,631 words Article 1640LPolyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic assembly lines, often attain the conformations that establish biological activity by cyclization constraints introduced by tailoring...

• Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy

  Authors:Ji-Hye Nah, Hye-Jin Kim, Han-Na Lee, Mi-Jin Lee, Si-Sun Choi, and Eung-Soo KimFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20134,669 words Report 1760LPolyketide belongs to a family of abundant natural products typically produced by the filamentous soil bacteria Streptomyces. Similar to the biosynthesis of most secondary metabolites produced in the Streptomyces...

• Correlation between In vitro susceptibility and treatment outcome with azithromycin in gonorrhoea: A prospective study

  Authors:P. Khaki, P. Bhalla, A. Sharma, and V. KumarFrom:Indian Journal of Medical Microbiology (Vol. 25, Issue 4)

  October-December 20072,254 words Clinical report 1650LByline: P. Khaki, P. Bhalla, A. Sharma, V. Kumar Purpose: This prospective study was carried out to determine the antimicrobial susceptibility of Neisseria gonorrhoeae isolates by disc diffusion method and minimum...

• Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.

  Authors:Dominik A. Herbst, Roman P. Jakob, Franziska Zähringer, and Timm MaierFrom:Nature (Vol. 531, Issue 7595) Peer-Reviewed

  Mar. 24, 201611,251 words Article 1520LA hybrid crystal structure of Mycobacterium smegmatis mycocerosic acid synthase, a multienzyme involved in the biosynthesis of mycobacterial branched-chain fatty acids, exemplifies the organization of fully-reducing...

• Topical azithromycin enters market as treatment for bacterial conjunctivitis

  Author:Nancy GrovesFrom:Ophthalmology Times (Vol. 32, Issue 18) Peer-Reviewed

  Sept. 15, 2007925 words Article 1520LAn ophthalmic formulation of the widely used antibiotic azithromycin is now commercially available for the treatment of bacterial conjunctivitis, offering clinicians a drug that is as effective as other topical...

• Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

  Authors:Sietske Grijseels, Carsten Pohl, Jens Christian Nielsen, Zahida Wasil, Yvonne Nygard, Jens Nielsen, et al.From:Fungal Biology and Biotechnology (Vol. 5, Issue 1) Peer-Reviewed

  Dec. 19, 20189,703 words Report 1670LBackground Filamentous fungi are important producers of secondary metabolites, low molecular weight molecules that often have bioactive properties. Calbistrin A is a secondary metabolite with an interesting structure...

• Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

  Authors:Blaine A. Pfeifer, Suzanne J. Admiraal, Hugo Gramajo, David E. Cane, and Chaitan KhoslaFrom:Science (Vol. 291, Issue 5509) Peer-Reviewed

  Mar. 2, 20013,224 words Article The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional...

• Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

  Authors:Jason M. Crawford, Tyler P. Korman, Jason W. Labonte, Anna L. Vagstad, Eric A. Hill, Oliver Kamari-Bidkorpeh, et al.From:Nature (Vol. 461, Issue 7267) Peer-Reviewed

  Oct. 22, 20094,009 words Report 1530LPolyketides are a class of natural products with diverse structures and biological activities. The structural variability of aromatic products of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS...

• Structural rearrangements of a polyketide synthase module during its catalytic cycle

  Authors:Jonathan R. Whicher, Somnath Dutta, Douglas A. Hansen, Wendi A. Hale, Joseph A. Chemler, Annie M. Dosey, et al.From:Nature (Vol. 510, Issue 7506) Peer-Reviewed

  June 26, 20146,463 words Report 1470LAuthor(s): Jonathan R. Whicher [1, 2, 7]; Somnath Dutta [1, 7]; Douglas A. Hansen [1, 3]; Wendi A. Hale [4]; Joseph A. Chemler [1]; Annie M. Dosey [1]; Alison R. H. Narayan [1]; Kristina Håkansson (corresponding author)...

• Diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, kills various human cancer cells

  Authors:Atsushi Nakabachi and Keiko OkamuraFrom:PLoS ONE (Vol. 14, Issue 6) Peer-Reviewed

  June 10, 20193,605 words Report 1500LDiaphorin is a polyketide produced by Candidatus Profftella armatura (Betaproteobacteria), an organelle-like defensive symbiont harbored by a plant sap-sucking insect, Asian citrus psyllid Diaphorina citri (Hemiptera:...

• Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

  Authors:TuAnh Nguyen, Keishi Ishida, Holger Jenke-Kodama, Elke Dittmann, Cristian Gurgui, Thomas Hochmuth, et al.From:Nature Biotechnology (Vol. 26, Issue 2) Peer-Reviewed

  Feb. 20086,261 words Report 1390LModular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many polyketides of therapeutic value. In contrast to PKSs that provide acyltransferase (AT) activities in cis, trans-AT PKSs lack...

• Antimicrobial susceptibility testing of Helicobacter pylori to selected agents by agar dilution method in Shiraz-Iran

  Authors:J. Kohanteb, A. Bazargani, M. Saberi-Firoozi, and A. MobasserFrom:Indian Journal of Medical Microbiology (Vol. 25, Issue 4)

  October-December 20072,847 words Article 1620LByline: J. Kohanteb, A. Bazargani, M. Saberi-Firoozi, A. Mobasser Purpose: To assess the pattern of antimicrobial susceptibility profile of Helicobacter pylori isolates from patients with gastritis, duodenal ulcer...

• Citrus pest's little helper

  From:Nature (Vol. 499, Issue 7458) Peer-Reviewed

  July 18, 2013127 words Brief article 1280LA notorious agricultural pest harbours a bacterium that produces a toxin which may deter its predators. Orange-grove farmers dread the Asian citrus psyllid (Diaphorina citri), a small insect that carries the bacterial...

• Exploring the diversity of marine-derived fungal polyketide synthases

  Authors:Kimberly M. Mayer, Jermaine Ford, Gordon R. Macpherson, David Padgett, Brigitte Volkmann-Kohlmeyer, Jan Kohlmeyer, et al.From:Canadian Journal of Microbiology (Vol. 53, Issue 2) Peer-Reviewed

  Feb. 20077,019 words Article 1460LAbstract: Using an approach based on polymerase chain reaction (PCR), we examined the diversity of polyketide synthase (PKS) genes present in 160 marine fungal isolates, representing 142 species. We obtained...