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    Academic Journals

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• Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels

  Authors:Ming Shi, Yong Zhang, Jing Zhang, Wei Liu, and Lu XingFrom:The Brazilian Journal of Infectious Diseases (Vol. 16, Issue 1) Peer-Reviewed

  January-February 20123,232 words Article 1830LHepatitis B virus (HBV) genotype and precore and basal core promoter (BCP) mutants in the patients with persistently normal alanine aminotransferase (ALT) and low serum HBV-DNA levels are unclear. The aim of this study...

• Diagnostic value of secreted frizzled-related protein 2 gene promoter hypermethylation in stool for colorectal cancer: A meta-analysis

  Authors:Zhiran Zhou, Huitian Zhang, and Yunxia LeiFrom:Journal of Cancer Research and Therapeutics (Vol. 12, Issue 5) Peer-Reviewed

  Oct. 20161,590 words Report 1420LByline: Zhiran. Zhou, Huitian. Zhang, Yunxia. Lei Objective: To evaluate the diagnostic value of secreted frizzled-related protein 2 (SFRP2) gene promoter hypermethylation in stool for colorectal cancer (CRC)....

• Serum Starvation Induces DRAM Expression in Liver Cancer Cells via Histone Modifications within Its Promoter Locus

  Authors:Peihua Ni, Hong Xu, Changqiang Chen, Jiayi Wang, Xiangfan Liu, Yiqun Hu, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 12, 20124,926 words Article 1470LAuthor(s): Peihua Ni 1 , 2 , Hong Xu 3 , Changqiang Chen 2 , Jiayi Wang 2 , Xiangfan Liu 2 , Yiqun Hu 2 , Qishi Fan 2 , Zhaoyuan Hou 3 , * , Yang Lu 1 , * Introduction Inactivation of cell-death pathways is a...

• Core promoters across the genome

  Authors:Nevena Cvetesic and Boris LenhardFrom:Nature Biotechnology (Vol. 35, Issue 2) Peer-Reviewed

  Feb. 20171,687 words Report 1550LAuthor(s): Nevena Cvetesic (corresponding author) [1]; Boris Lenhard (corresponding author) [1] Promoters, the sites that define where transcription starts, are fundamental to genome function. Although methods have...

• GE to boost yields with Synpromics' synthetic promoters

  From:Nature Biotechnology (Vol. 35, Issue 2) Peer-Reviewed

  Feb. 2017195 words Brief article 1440LGE Healthcare and Scottish synthetic biology firm Synpromics partnered to develop a new library of synthetic promoters for GE's biologics manufacturing. Synpromics CEO David Venables said in January that the privately...

• Transcriptional control of the Pseudomonas TOL plasmid catabolic operons is achieved through an interplay of host factors and plasmid-encoded regulators

  Authors:Juan L. Ramos, Silvia Marques, and Kenneth N. TimmisFrom:Annual Review of Microbiology (Vol. 51) Peer-Reviewed

  Annual 199713,395 words Article The xyl genes of Pseudomonas putida TOL plasmid that specify catabolism of toluene and xylenes are organized in four transcriptional units: the upper-operon xylUWCAMBN for conversion of toluene/xylenes into...

• Meditation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase

  Authors:Venkatesh Krishnan and Ming-Jer TsaiFrom:Science (Vol. 278, Issue 5345) Peer-Reviewed

  Dec. 12, 19972,432 words Article A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to mediate Shh...

• A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the Italian population do not support a large effect on Alzheimer's disease risk

  Authors:Letizia Polito, Francesca Prato, Serena Rodilossi, Eleonora Ateri, Daniela Galimberti, Elio Scarpini, et al.From:International Journal of Alzheimer's DiseasePeer-Reviewed

  Annual 20113,432 words Report 1560LAlzheimer's disease (AD) is a neurodegenerative disorder whose clinical onset is mainly characterized by memory loss. During AD progression, behavioral and psychological symptoms of dementia (BPSD) frequently occur. In...

• Identification of a novel [beta]-cell glucokinase (GCK) promoter mutation (- 71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humans

  Authors:Daniela Gasperikova, Nicolas D. Tribble, Juraj Stanik, Miroslava Huckova, Nadezda Misovicova, Martijn van de Bunt, et al.From:Diabetes (Vol. 58, Issue 8) Peer-Reviewed

  Aug. 20094,270 words Report 1480LOBJECTIVE--Inactivating mutations in glucokinase (GCK) cause mild fasting hyperglycemia. Identification of a GCK mutation has implications for treatment and prognosis; therefore, it is important to identify these...

• Decipher the complexity of cis-regulatory regions by a modified Cas9

  Authors:Steven Kirchner, Stefanie Reuter, Anika Westphal, Ralf Mrowka, and Hans A KestlerFrom:PLoS ONE (Vol. 15, Issue 7) Peer-Reviewed

  July 2, 20208,294 words Report 1330LAuthor(s): Steven Kirchner *, Stefanie Reuter, Anika Westphal, Ralf Mrowka Introduction Transcriptional regulation of genes is one of the key points for gene expression in general. Cis -regulatory elements are...

• A Soluble Factor from Trypanosoma cruzi Inhibits Transforming Growth Factor-[sz]-Induced MAP Kinase Activation and Gene Expression in Dermal Fibroblasts

  Authors:G. Adam Mott, Jaime A. Costales, and Barbara A. BurleighFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 8, 20117,571 words Article 1630LThe protozoan parasite Trypanosoma cruzi, which causes human Chagas' disease, exerts a variety of effects on host extracellular matrix (ECM) including proteolytic degradation of collagens and dampening of ECM gene...

• A Conserved GA Element in TATA-Less RNA Polymerase II Promoters

  Authors:Martin Seizl, Holger Hartmann, Friederike Hoeg, Fabian Kurth, Dietmar E. Martin, Johannes Soding, et al.From:PLoS ONE (Vol. 6, Issue 11) Peer-Reviewed

  Nov. 16, 20115,732 words Article 1450LInitiation of RNA polymerase (Pol) II transcription requires assembly of the pre-initiation complex (PIC) at the promoter. In the classical view, PIC assembly starts with binding of the TATA box-binding protein (TBP) to...

• Targeting of De Novo DNA Methylation Throughout the Oct-4 Gene Regulatory Region in Differentiating Embryonic Stem Cells

  Authors:Rodoniki Athanasiadou, Dina de Sousa, Kevin Myant, Cara Merusi, Irina Stancheva, and Adrian BirdFrom:PLoS ONE (Vol. 5, Issue 4) Peer-Reviewed

  Apr. 1, 20107,186 words Article 1430LDifferentiation of embryonic stem (ES) cells is accompanied by silencing of the Oct-4 gene and de novo DNA methylation of its regulatory region. Previous studies have focused on the requirements for promoter region...

• Genetic and Molecular Functional Characterization of Variants within TNFSF13B, a Positional Candidate Preeclampsia Susceptibility Gene on 13q

  Authors:Mona H. Fenstad, Matthew P. Johnson, Linda T. Roten, Per A. Aas, Siri Forsmo, Kjetil Klepper, et al.From:PLoS ONE (Vol. 5, Issue 9) Peer-Reviewed

  Sept. 29, 20107,888 words Article 1490LBackground Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We...

• GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

  Authors:Hsien-Sung Huang and Schahram AkbarianFrom:PLoS ONE (Vol. 2, Issue 8) Peer-Reviewed

  Aug. 29, 20073,677 words Report 1660LDysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs, including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (GAD.sub.67) GABA synthesis enzyme. The...

• The CCCTC-Binding Factor (CTCF) of Drosophila Contributes to the Regulation of the Ribosomal DNA and Nucleolar Stability

  Authors:Paola A. Guerrero and Keith A. MaggertFrom:PLoS ONE (Vol. 6, Issue 1) Peer-Reviewed

  Jan. 20, 20118,157 words Article 1610LIn the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating...

• Yin Yang 1 Intronic Binding Sequences and Splicing Elicit Intron-Mediated Enhancement of Ubiquitin C Gene Expression

  Authors:Marzia Bianchi, Rita Crinelli, Elisa Giacomini, Elisa Carloni, Lucia Radici, and Mauro MagnaniFrom:PLoS ONE (Vol. 8, Issue 6) Peer-Reviewed

  June 12, 201315,955 words Article 1530LIn a number of organisms, introns affect expression of the gene in which they are contained. Our previous studies revealed that the 5'-UTR intron of human ubiquitin C (UbC) gene is responsible for the boost of reporter...

• Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells

  Authors:Shireesha Sankella, Abhimanyu Garg, and Anil K. AgarwalFrom:PLoS ONE (Vol. 11, Issue 9) Peer-Reviewed

  Sept. 9, 201610,999 words Article 1390LMonoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine,...

• MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma

  Authors:Laura-Nanna Lohkamp, Maren Schinz, Claire Gehlhaar, Katrin Guse, Ulrich-Wilhelm Thomale, Peter Vajkoczy, et al.From:PLoS ONE (Vol. 11, Issue 6) Peer-Reviewed

  June 2, 20165,724 words Report 1520LGiant Cell Glioblastoma (gcGBM) and Pleomorphic Xanthoastrocytoma (PXA) are rare astroglial tumors of the central nervous system. Although they share certain histomorphological and immunohistochemical features, they are...

• Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer

  Authors:Keita Kojima, Takatoshi Nakamura, Makoto Ohbu, Hiroshi Katoh, Yosuke Ooizumi, Kazuharu Igarashi, et al.From:PLoS ONE (Vol. 13, Issue 5) Peer-Reviewed

  May 10, 20187,507 words Report 1310LBackground Progression of colorectal cancer (CRC) has been explained by genomic abnormalities along with the adenoma-carcinoma sequence theory (ACS). The aim of our study is to elucidate whether the promoter DNA...