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    Academic Journals

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• Application of High-Throughput Isothermal Denaturation to Assess Protein Stability and Screen for Ligands

  Authors:Guillermo A. Senisterra, Bum Soo Hong, Hee-Won Park, and Masoud VedadiFrom:Journal of Biomolecular Screening (Vol. 13, Issue 5) Peer-Reviewed

  Aug. 20084,709 words Report 1580LByline: Guillermo A. Senisterra (Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada); Bum Soo Hong (Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada); Hee-Won...

• Helicase-dependent amplification: use in OnChip amplification and potential for point-of-care diagnostics

  Authors:Dennie Andresen, Markus von Nickisch-Rosenegk, and Frank F BierFrom:Expert Review of Molecular Diagnostics (Vol. 9, Issue 7) Peer-Reviewed

  Oct. 20094,297 words Article 1470LAuthor(s): Dennie Andresen [[dagger]] 1 , Markus von Nickisch-Rosenegk 2 , Frank F Bier 3 Keywords: DNA microarray; helicase-dependent amplification; multiplex detection; OnChip amplification; point of care...

• Development and Evaluation of Single Domain Antibodies for Vaccinia and the L1 Antigen

  Authors:Scott A. Walper, Jinny L. Liu, Daniel Zabetakis, George P. Anderson, and Ellen R. GoldmanFrom:PLoS ONE (Vol. 9, Issue 9) Peer-Reviewed

  Sept. 11, 20148,647 words Article 1400LThere is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target...

• Effect of Trehalose on Oligomeric State and Anti-Aggregation Activity of [alpha]B-Crystallin.

  Authors:Natalia A. Chebotareva, Tatiana B. Eronina, Valeriya V. Mikhaylova, Svetlana G. Roman, Kristina V. Tugaeva, and Boris I. KurganovFrom:Biochemistry (Moscow) (Vol. 87, Issue 2) Peer-Reviewed

  Feb. 20227,162 words Article 1630L[alpha]B-Crystallin ([alpha]B-Cr), one of the main crystalline lens proteins, along with other crystallins maintains lens transparency suppressing protein aggregation and thus preventing cataractogenesis. [alpha]B-Cr...

• Nonsurgical, radiofrequency collagen denaturation for stress urinary incontinence: retrospective 3-year evaluation

  Authors:Rodney A Appell, Gita Singh, Ira W Klimberg, Christopher Graham, Saad Juma, W Glen Wells, et al.From:Expert Review of Medical Devices (Vol. 4, Issue 4) Peer-Reviewed

  July 20074,151 words Clinical report 1470LAuthor(s): Rodney A Appell [[dagger]] 1 , Gita Singh 2 , Ira W Klimberg 3 , Christopher Graham 4 , Saad Juma 5 , W Glen Wells 6 , Angelo Kanellos 7 , Sandra F Reilley 8 Keywords: bladder outlet hypermobility;...

• OneG: A Computational Tool for Predicting Cryptic Intermediates in the Unfolding Kinetics of Proteins under Native Conditions

  Authors:Tambi Richa and Thirunavukkarasu SivaramanFrom:PLoS ONE (Vol. 7, Issue 3) Peer-Reviewed

  Mar. 7, 20129,900 words Article 1550LAuthor(s): Tambi Richa, Thirunavukkarasu Sivaraman * Introduction Each protein adopts a specific well-defined three-dimensional (3D) structure, which is important for its biological activities. The relationships...

• Visualization of Early Events in Acetic Acid Denaturation of HIV-1 Protease: A Molecular Dynamics Study

  Authors:Aditi Narendra Borkar, Manoj Kumar Rout, and Ramakrishna V. HosurFrom:PLoS ONE (Vol. 6, Issue 6) Peer-Reviewed

  June 29, 20115,056 words Report 1640LProtein denaturation plays a crucial role in cellular processes. In this study, denaturation of HIV-1 Protease (PR) was investigated by all-atom MD simulations in explicit solvent. The PR dimer and monomer were...

• Anti-Inflammatory, Antioxidant, and Anthelmintic Activities of Ocimum basilicum (Sweet Basil) Fruits.

  Authors:Clement Osei Akoto, Akwasi Acheampong, Yaw Duah Boakye, Abdulai A. Naazo, and Derrick H. AdomahFrom:Journal of Chemistry (Vol. 2020) Peer-Reviewed

  June 30, 20206,498 words Article 1390LBasil (Ocimum basilicum Linn.) is a plant that has found use in traditional medicine and household remedy against human ailments. The present study aimed at investigating hexane and ethanol fruit extracts of Ocimum...

• Proteolytic Characteristics of Cathepsin D Related to the Recognition and Cleavage of Its Target Proteins

  Authors:Huiying Sun, Xiaomin Lou, Qiang Shan, Ju Zhang, Xu Zhu, Jia Zhang, et al.From:PLoS ONE (Vol. 8, Issue 6) Peer-Reviewed

  June 20, 20137,662 words Article 1480LAuthor(s): Huiying Sun 1,2, Xiaomin Lou 1, Qiang Shan 1,2, Ju Zhang 1, Xu Zhu 1,2, Jia Zhang 3, Yang Wang 1,2, Yingying Xie 1,2, Ningzhi Xu 4,*, Siqi Liu 1,* Introduction Cathepsins are a class of lysosomal...

• STIM1-mediated store-operated calcium entry uses a protein unfolding/oligomerization-coupled mechanism

  Authors:P.B. Stathopulos, L. Zheng, G.-Y. Li, M.J. Plevin, and M. IkuraFrom:Biochemistry and Cell Biology (Vol. 88, Issue 2) Peer-Reviewed

  Apr. 2010186 words Brief article, Repor... 120LStromal interaction molecule-1 (STIM1) activates storeoperated [Ca.sup.2+] entry (SOCE) in response to diminished luminal [Ca.sup.2+] levels. We have recently determined the solution structure of the [Ca.sup.2+]-sensing...

• Hyperthermophile Protein Behavior: Partially-Structured Conformations of Pyrococcus furiosus Rubredoxin Monomers Generated through Forced Cold-Denaturation and Refolding

  Authors:Sanjeev Kumar Chandrayan, Satya Prakash, Shubbir Ahmed, and Purnananda GuptasarmaFrom:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 6, 201412,448 words Article 1620LAuthor(s): Sanjeev Kumar Chandrayan 2, Satya Prakash 1,2, Shubbir Ahmed 2, Purnananda Guptasarma 1,2,* Introduction We reported some years ago [1] that the hyperthermophile protein, Pyrococcus furiosus...

• Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum

  Authors:Ya-Jun Liu, Shiyue Liu, Sheng Dong, Renmin Li, Yingang Feng, and Qiu CuiFrom:Biotechnology for Biofuels (Vol. 11, Issue 1) Peer-Reviewed

  Jan. 13, 20186,943 words Article 1460LAuthor(s): Ya-Jun Liu1 , Shiyue Liu1,2 , Sheng Dong1 , Renmin Li1,2 , Yingang Feng1 and Qiu Cui1 Background Cellulosome is an extracellular multiprotein complex produced by cellulolytic bacteria. This...

• Development of a Rapid Molecular Test Format Based on Isothermal Recombinase Polymerase Amplification Technique and Lateral Flow Method for Detection of [bla.sub.OXA-48]/ [bla.sub.OXA-48]'in Saptanmasi Icin Izotermal Rekombinaz Polimeraz Amplifikasyon Teknigi ve Yanal Akim Yontemine Dayali Hizli Bir Molekuler Test Formatinin Gelistirilmesi

  Authors:Mert Ahmet Kuskucu, Gokhan Aygun, Asiye Karakullukcu, Nergiz Imamova, Omer Kucukbasmaci, and Kenan MidilliFrom:KLIMIK Journal (Vol. 31, Issue 3) Peer-Reviewed

  Dec. 20183,285 words Report 1420LObjective: Molecular tests are rapid, reliable tools for the detection of carbapenem resistance, but their use is limited due to their cost, requirement for well-trained technicians and highly sophisticated...

• Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

  Authors:Amy R. Wyatt, Janet R. Kumita, Natalie E. Farrawell, Christopher M. Dobson, and Mark R. WilsonFrom:PLoS ONE (Vol. 10, Issue 6) Peer-Reviewed

  June 23, 20159,083 words Article 1640LAlpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a...

• Dissimilarity in the Folding of Human Cytosolic Creatine Kinase Isoenzymes

  Authors:Yin Wang, Sha Wang, Yan-Song Gao, Zhe Chen, Hai-Meng Zhou, and Yong-Bin YanFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 9, 20116,349 words Article 1540LCreatine kinase (CK, EC 2.7.3.2) plays a key role in the energy homeostasis of excitable cells. The cytosolic human CK isoenzymes exist as homodimers (HMCK and HBCK) or a heterodimer (MBCK) formed by the muscle CK...

• Immunoglobulin G structure and rheumatoid factor epitopes

  Authors:Sheila Lefoli Maibom-Thomsen, Nicole Hartwig Trier, Bettina Eide Holm, Kirsten Beth Hansen, Morten Ib Rasmussen, Anna Chailyan, et al.From:PLoS ONE (Vol. 14, Issue 6) Peer-Reviewed

  June 14, 201912,604 words Report 1580LAntibodies are important for immunity and exist in several classes (IgM, IgD, IgA, IgG, IgE). They are composed of symmetric dimeric molecules with two antigen binding regions (Fab) and a constant part (Fc), usually...

• Nuclease-Assisted Suppression of Human DNA Background in Sepsis

  Authors:Yajing Song, Christian G. Giske, Patrik Gille-Johnson, Olof Emanuelsson, Joakim Lundeberg, and Peter GyarmatiFrom:PLoS ONE (Vol. 9, Issue 7) Peer-Reviewed

  July 30, 20143,871 words Article 1500LSepsis is a severe medical condition characterized by a systemic inflammatory response of the body caused by pathogenic microorganisms in the bloodstream. Blood or plasma is typically used for diagnosis, both containing...

• A Novel Approach for Purification and Selective Capture of Membrane Vesicles of the Periodontopathic Bacterium, Porphyromonas gingivalis: Membrane Vesicles Bind to Magnetic Beads Coated with Epoxy Groups in a Noncovalent, Species-Specific Manner

  Authors:Ryoma Nakao, Kenji Kikushima, Hideo Higuchi, Nozomu Obana, Nobuhiko Nomura, Dongying Bai, et al.From:PLoS ONE (Vol. 9, Issue 5) Peer-Reviewed

  May 15, 20148,291 words Article 1440LMembrane vesicles (MVs) of Porphyromonas gingivalis are regarded as an offensive weapon of the bacterium, leading to tissue deterioration in periodontal disease. Therefore, isolation of highly purified MVs is...

• Making a network of hydrophobic clusters. (Perspective: protein folding)

  Author:Robert L. BaldwinFrom:Science (Vol. 295, Issue 5560) Peer-Reviewed

  Mar. 1, 20021,167 words Article It has been hotly debated whether a hydrophobic collapse precedes or occurs concomitantly with formation of secondary structures at the beginning of protein folding (1). The role of secondary structures in guiding the...

• Effect of Heavy Atoms on the Thermal Stability of [alpha]-Amylase from Aspergillus oryzae

  Authors:Michihiro Sugahara, Michiyo Takehira, and Katsuhide YutaniFrom:PLoS ONE (Vol. 8, Issue 2) Peer-Reviewed

  Feb. 25, 20135,436 words Article 1410LAuthor(s): Michihiro Sugahara * , Michiyo Takehira, Katsuhide Yutani Introduction Enzymes are currently used in many different industrial products and processes [1]. To enhance thermal stability of highly useful...