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• Notoginsenoside Rb1 inhibits activation of ERK and p38 MAPK pathways induced by hypoxia and hypercapnia

  Authors:Xiaoxiao Qiu, Mengxiao Zheng, Dong Song, Linjing Huang, Lanlan Tang, Lei Ying, et al.From:Experimental and Therapeutic Medicine (Vol. 11, Issue 6) Peer-Reviewed

  June 20164,771 words Article 1250LThe aim of the present study was to investigate the effect of notoginsenoside Rb1 (Rb1) on the ERK and p38 MAPK pathways in primary cultured pulmonary arterial smooth muscle cells (PASMCs) exposed to hypoxia and...

• In vivo and in vitro studies on the roles of p38 mitogen-activated protein kinase and NADPH-cytochrome P450 reductase in Alzheimer's disease

  Authors:Yunyi Yao, Jin-Zhong Huang, Liang Chen, Yingqi Chen, and Xianhong LiFrom:Experimental and Therapeutic Medicine (Vol. 14, Issue 5) Peer-Reviewed

  Nov. 20174,649 words Report 1320LAlzheimer's disease (AD) is a chronic neurodegenerative disease with an increasing morbidity rate. As one of the most important signaling pathways that responds to inflammation and degeneration, the p38...

• MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

  Authors:Saema Ansar, Sajedeh Eftekhari, Roya Waldsee, Elisabeth Nilsson, Ola Nilsson, Hans Saveland, et al.From:BMC Neuroscience (Vol. 14, Issue 1) Peer-Reviewed

  Jan. 23, 20135,712 words Report 1530LAuthor(s): Saema Ansar1 , Sajedeh Eftekhari1 , Roya Waldsee1 , Elisabeth Nilsson1 , Ola Nilsson2 , Hans Säveland2 and Lars Edvinsson1 Background Large efforts have during the last few decades been made to...

• Identification of three MAPKKKs forming a linear signaling pathway leading to programmed cell death in Nicotiana benthamiana

  Authors:Masayoshi Hashimoto, Ken Komatsu, Kensaku Maejima, Yukari Okano, Takuya Shiraishi, Kazuya Ishikawa, et al.From:BMC Plant Biology (Vol. 12, Issue 1) Peer-Reviewed

  July 8, 20127,334 words Report 1480LBackground The mitogen-activated protein kinase (MAPK) cascade is an evolutionarily ancient mechanism of signal transduction found in eukaryotic cells. In plants, MAPK cascades are associated with responses to...

• Effect of exercise intensity on skeletal muscle AMPK signaling in humans

  Authors:Zhi-Ping Chen, Terry J. Stephens, Sid Murthy, Benedict J. Canny, Mark Hargreaves, Lee A. Witters, et al.From:Diabetes (Vol. 52, Issue 9) Peer-Reviewed

  Sept. 20036,163 words Article The effect of exercise intensity on skeletal muscle AMP-activated protein kinase (AMPK) signaling and substrate metabolism was examined in eight men cycling for 20 min at each of three sequential intensities: low (40 [+...

• Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-[alpha] secretion and apoptosis

  Authors:Amar Nagila, Janjuree Netsawang, Aroonroong Suttitheptumrong, Atthapan Morchang, Sasiprapa Khunchai, Chatchawan Srisawat, et al.From:Virology Journal (Vol. 10, Issue 1) Peer-Reviewed

  Apr. 4, 20133,719 words Report 1560LBackground Hepatic injury in dengue virus (DENV) infection is authenticated by hepatomegaly and an upsurge in transaminase levels. DENV replicates in hepatocytes and causes hepatocyte apoptosis both in vitro and in...

• MK3 controls Polycomb target gene expression via negative feedback on ERK

  Authors:Peggy Prickaerts, Hanneke EC Niessen, Emmanuele Mouchel-Vielh, Vivian EH Dahlmans, Guus GH van den Akker, Claudia Geijselaers, et al.From:Epigenetics & Chromatin (Vol. 5, Issue 1) Peer-Reviewed

  Aug. 7, 20128,992 words Report 1290LBackground Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation...

• Nell-1 Enhances Osteogenic Differentiation of Pre-Osteoblasts on Titanium Surfaces via the MAPK-ERK Signaling Pathway

  Authors:Mei-jie Shen, Ge-ge Wang, Yu-zhen Wang, Jing Xie, and Xi DingFrom:Cellular Physiology and Biochemistry (Vol. 50, Issue 4) Peer-Reviewed

  Nov. 1, 20186,710 words Article 1440LBackground/Aims: This study aimed to investigate the effect of Nell-1 on the osteogenic behaviors of pre-osteoblasts on titanium (Ti) surfaces and to identify the underlying signaling pathway. Methods: Nell-1 at...

• Comparative amino acid decomposition analysis of potent type I p38[alpha] inhibitors

  Authors:Ahmad Ebadi, Nima Razzaghi-Asl, Mehdi Khoshneviszadeh, and Ramin MiriFrom:DARU Journal of Pharmaceutical Sciences (Vol. 21, Issue 1) Peer-Reviewed

  May 29, 20135,523 words Report 1250LBackground and purpose of the study p38[alpha] is a member of mitogen-activated protein kinases (MAPK) considered as a prominent target in development of anti-inflammatory agents. Any abnormality in the...

• Ssanghwa-tang, an oriental herbal cocktail, exerts anti-melanogenic activity by suppression of the p38 MAPK and PKA signaling pathways in B16F10 cells

  Authors:Aeyung Kim, Nam-Hui Yim, Minju Im, Young Pil Jung, Chun Liang, Won-Kyung Cho, et al.From:BMC Complementary and Alternative Medicine (Vol. 13, Issue 1) Peer-Reviewed

  Aug. 28, 20135,811 words Report 1600LBackground Ssanghwa-tang (SHT) is a widely used medication for the treatment of fatigue, pain, inflammation, hypothermia, erectile dysfunction, cancer, and osteoporosis in Asia, however, role of SHT on the melanin...

• MAPK-dependent JA and SA signalling in Nicotiana attenuataaffects plant growth and fitness during competition with conspecifics

  Authors:Stefan Meldau, Lynn Ullman-Zeunert, Geetha Govind, Stefan Bartram, and Ian T BaldwinFrom:BMC Plant Biology (Vol. 12, Issue 1) Peer-Reviewed

  Nov. 13, 201210,304 words Report 1490LBackground Induced defense responses to herbivores are generally believed to have evolved as cost-saving strategies that defer the fitness costs of defense metabolism until these defenses are needed. The fitness...

• The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress

  Authors:Maria Soriano-Carot, M Carmen Bano, and J Carlos IgualFrom:Cell Division (Vol. 7) Peer-Reviewed

  Feb. 1, 20128,742 words Report 1500LBackground The maintenance of genomic integrity is essential for cell viability. Complex signalling pathways (DNA integrity checkpoints) mediate the response to genotoxic stresses. Identifying new functions involved...

• Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells

  Authors:Pengfei Ba, Xiaoyu Duan, Guo Fu, L.V. Shuyan, Pishan Yang, and Qinfeng SunFrom:Molecular Medicine Reports (Vol. 16, Issue 1) Peer-Reviewed

  July 20174,084 words Article 1370LThe extracellular signal-regulated protein kinase 1/2 (Erk1/2) and p38 mitogen-activated protein-kinase pathways serve important roles in the regulation of osteogenic and chondrogenic differentiation in mesenchymal stem...

• The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases

  Authors:Ashley A Horton, Bo Wang, Lauren Camp, Mark S Price, Arora Arshi, Mate Nagy, et al.From:BMC Genomics (Vol. 12, Issue 1) Peer-Reviewed

  Nov. 23, 20119,093 words Article 1630LBackground Anopheles gambiae is the primary mosquito vector of human malaria parasites in sub-Saharan Africa. To date, three innate immune signaling pathways, including the nuclear factor (NF)-kappaB-dependent Toll...

• Anti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages

  Authors:Wan-Kyu Ko, Soo-Hong Lee, Sung Jun Kim, Min-Jae Jo, Hemant Kumar, In-Bo Han, et al.From:PLoS ONE (Vol. 12, Issue 6) Peer-Reviewed

  June 30, 20175,138 words Report 1550LPurpose The aim of this study was to investigate the anti-inflammatory effects of Ursodeoxycholic acid (UDCA) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods We induced an inflammatory...

• Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops

  Authors:Uddipan Sarma and Indira GhoshFrom:BMC Research Notes (Vol. 5, Issue 1) Peer-Reviewed

  June 13, 201212,332 words Report 1510LBackground Feedback loops, both positive and negative are embedded in the Mitogen Activated Protein Kinase (MAPK) cascade. In the three layer MAPK cascade, both feedback loops originate from the terminal layer and...

• The effects of low-dose Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function

  Authors:Jinzhou Zhu, Ke Yang, Yajun Jing, Run Du, Zhenbin Zhu, Lin Lu, et al.From:Cardiovascular Diabetology (Vol. 11, Issue 1) Peer-Reviewed

  Aug. 1, 20125,698 words Report 1290LBackground Patients with chronic kidney disease (CKD) are at high risk of cardiovascular disease (CVD). Endothelial progenitor cell (EPCs) dysfunction plays a key role in this pathogenesis. Uremic retention toxins...

• MAPK activation in mature cataract associated with Noonan syndrome

  Authors:Noriyasu Hashida, Xie Ping, and Kohji NishidaFrom:BMC Ophthalmology (Vol. 13, Issue 1) Peer-Reviewed

  Nov. 12, 20132,716 words Clinical report 1470LAuthor(s): Noriyasu Hashida1 , Xie Ping2 and Kohji Nishida1 Background Noonan syndrome (NS, OMIM 163950) is a common genetic disorder characterized by congenital heart disease, short stature, thoracic abnormality,...

• Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3[beta] signaling pathway

  Authors:Hongyu Shen, Liangpeng Li, Sujin Yang, Dandan Wang, Siying Zhou, Xiu Chen, et al.From:Molecular Medicine Reports (Vol. 16, Issue 2) Peer-Reviewed

  Aug. 20173,913 words Article 1420LTumor necrosis factor receptor-associated factor 6 (TRAF6) is an endogenous adaptor of innate and adaptive immune responses, and serves a crucial role in tumor necrosis factor receptor and toll-like/interleukin-1...

• cGMP/PKG-I Pathway--Mediated GLUT1/4 Regulation by NO in Female Rat Granulosa Cells

  Authors:Ye Tian, Dai Heng, Kaili Xu, Wenbo Liu, Xuechun Weng, Xusong Hu, et al.From:Endocrinology (Vol. 159, Issue 2) Peer-Reviewed

  Feb. 20186,292 words Report 1390LNitric oxide (NO) is a multifunctional gaseous molecule that plays important roles in mammalian reproductive functions, including follicular growth and development. Although our previous study showed that NO mediated...