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    Academic Journals

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• Effect of exercise intensity on skeletal muscle AMPK signaling in humans

  Authors:Zhi-Ping Chen, Terry J. Stephens, Sid Murthy, Benedict J. Canny, Mark Hargreaves, Lee A. Witters, et al.From:Diabetes (Vol. 52, Issue 9) Peer-Reviewed

  Sept. 20036,163 words Article The effect of exercise intensity on skeletal muscle AMP-activated protein kinase (AMPK) signaling and substrate metabolism was examined in eight men cycling for 20 min at each of three sequential intensities: low (40 [+...

• MK3 controls Polycomb target gene expression via negative feedback on ERK

  Authors:Peggy Prickaerts, Hanneke EC Niessen, Emmanuele Mouchel-Vielh, Vivian EH Dahlmans, Guus GH van den Akker, Claudia Geijselaers, et al.From:Epigenetics & Chromatin (Vol. 5, Issue 1) Peer-Reviewed

  Aug. 7, 20128,992 words Report 1290LBackground Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation...

• Anti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages

  Authors:Wan-Kyu Ko, Soo-Hong Lee, Sung Jun Kim, Min-Jae Jo, Hemant Kumar, In-Bo Han, et al.From:PLoS ONE (Vol. 12, Issue 6) Peer-Reviewed

  June 30, 20175,138 words Report 1550LPurpose The aim of this study was to investigate the anti-inflammatory effects of Ursodeoxycholic acid (UDCA) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods We induced an inflammatory...

• Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops

  Authors:Uddipan Sarma and Indira GhoshFrom:BMC Research Notes (Vol. 5, Issue 1) Peer-Reviewed

  June 13, 201212,332 words Report 1510LBackground Feedback loops, both positive and negative are embedded in the Mitogen Activated Protein Kinase (MAPK) cascade. In the three layer MAPK cascade, both feedback loops originate from the terminal layer and...

• Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis

  Authors:Yanling Sui, Zichun Zhao, Rong Liu, Bin Cai, and Dongsheng FanFrom:Neural Regeneration Research (Vol. 9, Issue 19) Peer-Reviewed

  Oct. 1, 20145,326 words Report 1400LByline: Yanling. Sui, Zichun. Zhao, Rong. Liu, Bin. Cai, Dongsheng. Fan Alterations in embryonic neural stem cells play crucial roles in the pathogenesis of amyotrophic lateral sclerosis. We hypothesized that...

• Akt in hepatic glucose suppression: a critical or casual role?

  Author:Helaine E. ResnickFrom:Diabetes (Vol. 61, Issue 7) Peer-Reviewed

  July 2012268 words Brief article 1440LAbnormalities of carbohydrate metabolism are a hallmark of diabetes, and numerous therapies target mechanisms that regulate both the fasted and fed states. In mammals, the liver ensures availability of carbohydrates...

• Molecular determination of benign and malignant thyroid tumors

  Author:Dagmar FuhrerFrom:Expert Review of Endocrinology & Metabolism (Vol. 1, Issue 6) Peer-Reviewed

  Nov. 20068,123 words Article 1490LAuthor(s): Dagmar Führer 1 Keywords: thyroid nodules; thyroid cancer; clonality; somatic mutation; TSH receptor; RET/PTC rearrangement; RAS; BRAF; PAX8/PPARγ rearrangement Thyroid nodules are the most...

• Protein kinase C inhibits cyclic adenosine monophosphate-induced calcium-activated and voltage-activated potassium channel activity in fawn-hooded rat pulmonary arterial smooth muscle via phosphodiesterases *

  Authors:Scott. A. Barman, Shu Zhu, Mary L. Meadows, and Richard. E. WhiteFrom:Chest (Vol. 128, Issue 6) Peer-Reviewed

  Dec. 2005318 words Brief article Abbreviations: BKCa = calcium-activated and voltage-activated potassium; cAMP = cyclic adenosine monophosphate; cGMP = cyclic guanidine monophosphate; PASMC = pulmonary arterial smooth muscle cell; PKC = protein kinase...

• Monitoring protein phosphorylation: phosphospecific antibodies and new techniques free signaling researchers from the perils of radioactivity handling. (Lab Consumer)

  Authors:Christine Yanicek and Jeffrey M. PerkelFrom:The Scientist (Vol. 17, Issue 13) Peer-Reviewed

  June 30, 2003846 words Article Signal transduction pathways comprise the cell's communications system; they transmit cues--from hormones, growth factors, or cytokines, for instance--that tell the ceil to proliferate, differentiate, activate (or...

• Pharmacological Activation of 5'AMP-Activated Protein Kinase (AMPK) In Vivo Acutely Decreases Blood Glucose and Chronically Increases Muscle GLUT4 in Normal and Diabetic Animals

  Authors:MASAKO NAKANO, TATSUYA HAYASHI, SHIN YONEMITSU, IZURU MASUDA, HIROAKI MASUZAKI, GEN INOUE, et al.From:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 2000285 words Brief article Physical exercise is a strong stimulator of muscle glucose transport and insulin sensitivity. Recent studies have suggested that AMPK is activated in response to ATP utilization and/or deprivation during exercise, and...

• Calmodulin trapping by calcium-calmodulin-dependent protein kinase

  Authors:Tobias Meyer, Phyllis I. Hanson, Lubert Stryer, and Howard SchulmanFrom:Science (Vol. 256, Issue 5060) Peer-Reviewed

  May 22, 19922,866 words Article Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces transient elevations in intracellular calcium into changes in the phosphorylation state and activity of target proteins. By fluorescence...

• Regulation of kainate receptors by cAMP-dependent protein kinase and phosphates

  Authors:Lu-Yang Wang, M.W. Salter, and J.F. MacDonaldFrom:Science (Vol. 253, Issue 5024) Peer-Reviewed

  Sept. 6, 19911,770 words Article EXCITATORY AMINO ACID RECEPTORS, which contain ion channels, can be broadly classified as N-methyl-D-aspartate (NMDA) or non-NMDA receptors on the basis of selective pharmacological antagonism [1]. Non-NMDA receptors...

• Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP

  Authors:Roberto Malinow, Howard Schulman, and Richard W. TsienFrom:Science (Vol. 245, Issue 4920) Peer-Reviewed

  Aug. 25, 19893,406 words Article Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP LONG-TERM POTENTIATION (LTP) of synaptic transmission results from tetanic stimulation of afferent fibers in the hippocampus [1] and...

• Dephosphorylation of Cdk2 Thr(super160) by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin

  Authors:Randy Y.C. Poon and Tony HunterFrom:Science (Vol. 270, Issue 5233) Peer-Reviewed

  Oct. 6, 19952,637 words Article The activation of cyclin-dependent kinases (CDKs) requires the phosphorylation of a conserved threonine ([Thr.sup.160] in Cdk2) by CDK-activating kinase (CAK). Human KAP (also called Cdi1), a CDK-associated phosphatase,...

• Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

  Authors:Ellen Freed, Marc Symons, Susan G. Macdonald, Frank McCormick, and Rosamaria RuggieriFrom:Science (Vol. 265, Issue 5179) Peer-Reviewed

  Sept. 16, 19943,517 words Article To identify proteins that may participate in the activation of the protein kinase Raf, proteins that interact with Raf were selected in a two-hybrid screen. Two members of the protein family were isolated that interacted...

• Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

  Authors:Hidenori Ichijo, Eisuke Nishida, Kenji Irie, Peter ten Dijke, Masao Saitoh, Tetsuo Moriguchi, et al.From:Science (Vol. 275, Issue 5296) Peer-Reviewed

  Jan. 3, 19973,413 words Article Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth factors and environmental stresses. A MAP kinase kinase kinase (MAPKKK), termed ASK1, was...

• Amelioration of vascular dysfunction in diabetic rats by an oral PKC Beta inhibitor

  Authors:Hidehiro Ishii, Michael R. Jorousek, Daisuke Koya, Chikako Takagi, Pu Xia, Allen Clermont, et al.From:Science (Vol. 272, Issue 5262) Peer-Reviewed

  May 3, 19962,659 words Article The vascular complications of diabetes mellitus have been correlated with enhanced activation of protein kinase C (PKC). LY333531, a specific inhibitor of the [beta] isoform of PKC, was synthesized and was shown to be a...

• The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-[beta]1 Deficient Mice

  Authors:Peter F. Mount, Kurt Gleich, Shanna Tam, Scott A. Fraser, Suet-Wan Choy, Karen M. Dwyer, et al.From:PLoS ONE (Vol. 7, Issue 1) Peer-Reviewed

  Jan. 9, 20126,578 words Article 1470LAuthor(s): Peter F. Mount 1 , 2 , * , Kurt Gleich 1 , 2 , Shanna Tam 3 , Scott A. Fraser 1 , 2 , Suet-Wan Choy 1 , 2 , 4 , Karen M. Dwyer 5 , Bo Lu 5 , Bryce Van Denderen 3 , Günter Fingerle-Rowson 6 , Richard Bucala 7...

• Anti-Inflammatory Activities of Inotilone from Phellinus linteus through the Inhibition of MMP-9, NF-[kappa]B, and MAPK Activation In Vitro and In Vivo

  Authors:Guan-Jhong Huang, Shyh-Shyun Huang, and Jeng-Shyan DengFrom:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 8, 20128,542 words Article 1460LAuthor(s): Guan-Jhong Huang 1 , * , Shyh-Shyun Huang 2 , Jeng-Shyan Deng 3 , * Introduction Inflammation, a physiological response to infection or injury, plays a critical role in chronic diseases, including...

• Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation

  Authors:Michele Graciotti, Mahmood Alam, Lev Solyakov, Ralf Schmid, Glenn Burley, Andrew R. Bottrill, et al.From:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 21, 20145,197 words Article 1480LAuthor(s): Michele Graciotti 1, Mahmood Alam 2, Lev Solyakov 2, Ralf Schmid 3, Glenn Burley 4, Andrew R. Bottrill 5, Christian Doerig 6, Paul Cullis 7, Andrew B. Tobin 2,* Introduction Despite the fact that...