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    Academic Journals

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• Correction: Parallel Force Assay for Protein-Protein Interactions

  From:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 20, 2015105 words Brief article, Corre... 890LAuthor(s): The PLOS ONE Staff There is an error in Equation 1. There should be a minus sign between the words RED and Ratio. Please view the correct equation below. [see PDF for formula] Reference 1....

• A Multi-Functional Imaging Approach to High-Content Protein Interaction Screening

  Authors:Daniel R. Matthews, Gilbert O. Fruhwirth, Gregory Weitsman, Leo M. Carlin, Enyinnaya Ofo, Melanie Keppler, et al.From:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 10, 201211,495 words Article 1500LAuthor(s): Daniel R. Matthews 1 , Gilbert O. Fruhwirth 1 , Gregory Weitsman 1 , Leo M. Carlin 1 , Enyinnaya Ofo 1 , Melanie Keppler 1 , Paul R. Barber 1 , 2 , Iain D. C. Tullis 2 , Borivoj Vojnovic 1 , 2 , Tony Ng 1 ,...

• Non-Redundant Unique Interface Structures as Templates for Modeling Protein Interactions

  Authors:Engin Cukuroglu, Attila Gursoy, Ruth Nussinov, and Ozlem KeskinFrom:PLoS ONE (Vol. 9, Issue 1) Peer-Reviewed

  Jan. 27, 20147,894 words Article 1480LAuthor(s): Engin Cukuroglu 1, Attila Gursoy 1,*, Ruth Nussinov 2,3, Ozlem Keskin 1,* Introduction Proteins physically interact with each other through their binding sites. Some proteins interact with their...

• Testing the interaction between snail and srsf1 using the yeast two-hybrid interaction system

  Authors:Allison Christensen, Anna Reinholz, Trevor A. Baumgartner, Jessica Warns, Shawn Krueger, Humaira Qureshi, et al.From:Proceedings of the North Dakota Academy of Science (Vol. 70) Peer-Reviewed

  Apr. 2016309 words Author abstract, Bri... 1540LThe SNAI1 gene encodes for a transcriptional factor (repressor) important in embryonic development and implicated in epithelial-to-mesenchymal transition (EMT), which occurs during cancer metastasis. Using a screen for...

• Klotho Protein: Its Role in Aging and Central Nervous System Pathology

  Authors:I.S. Boksha, T.A. Prokhorova, O.K. Savushkina, and E.B. TereshkinaFrom:Biochemistry (Moscow) (Vol. 82, Issue 9) Peer-Reviewed

  Sept. 201711,770 words Report 1630LThis review is devoted to Klotho protein and recent evidences for its functions in the brain. Information on transcriptional regulation of the klotho gene and posttranslational modifications of the protein resulting in...

• Interactions of U24 from Roseolovirus with WW domains: canonical vs noncanonical

  Authors:Yurou Sang, Rui Zhang, A. Louise Creagh, Charles A. Haynes, and Suzana K. StrausFrom:Biochemistry and Cell Biology (Vol. 95, Issue 3) Peer-Reviewed

  June 20176,924 words Report 1460LAbstract: U24 is a C-terminal membrane-anchored protein found in both human herpes virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminal segment that is rich in prolines (PPxY motif in both HHV-6A and 7; PxxP motif...

• Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis

  Authors:X.Y. Chen, Y.H. Chen, L.J. Zhang, Y. Wang, and Z.C. TongFrom:Brazilian Journal of Medical and Biological Research (Vol. 50, Issue 2) Peer-Reviewed

  Feb. 20174,081 words Report 1500LOsteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments...

• Benchmarking pathway interaction network for colorectal cancer to identify dysregulated pathways

  Authors:Q. Wang, C.-J. Shi, and S.-H. LvFrom:Brazilian Journal of Medical and Biological Research (Vol. 50, Issue 5) Peer-Reviewed

  May 20174,240 words Report 1330LDifferent pathways act synergistically to participate in many biological processes. Thus, the purpose of our study was to extract dysregulated pathways to investigate the pathogenesis of colorectal cancer (CRC) based on...

• Interactome-Wide Prediction of Protein-Protein Binding Sites Reveals Effects of Protein Sequence Variation in Arabidopsis thaliana

  Authors:Felipe Leal Valentim, Frank Neven, Peter Boyen, and Aalt D. J. van DijkFrom:PLoS ONE (Vol. 7, Issue 10) Peer-Reviewed

  Oct. 15, 201210,324 words Report 1470LAuthor(s): Felipe Leal Valentim 1 , Frank Neven 2 , Peter Boyen 2 , Aalt D. J. van Dijk 1 , * Introduction Genotype-to-phenotype relationships are mediated via molecular networks, including protein-protein...

• Parallel G-quadruplexes formed by guanine-rich microsatellite repeats inhibit human topoisomerase I

  Authors:A.M. Ogloblina, V.A. Bannikova, A.N. Khristich, T.S. Oretskaya, M.G. Yakubovskaya, and N.G. DolinnayaFrom:Biochemistry (Moscow) (Vol. 80, Issue 8) Peer-Reviewed

  Aug. 20157,697 words Report 1450LUsing UV and CD spectroscopy, we studied the thermodynamic stability and folding topology of G-quadruplexes ([G.sub.4]), formed by G-rich fragments in human microsatellites that differ in the number of guanosines within...

• Interaction between fibrinogen and insulin-like growth factor-binding protein-1 in human plasma under physiological conditions

  Authors:N. Gligorijevic and O. NedicFrom:Biochemistry (Moscow) (Vol. 81, Issue 2) Peer-Reviewed

  Feb. 20163,658 words Report 1380LFibrinogen is a plasma glycoprotein and one of the principle participants in blood coagulation. It interacts with many proteins during formation of a blood clot, including insulin-like growth factors (IGFs) and their...

• Network Properties of Complex Human Disease Genes Identified through Genome-Wide Association Studies

  Authors:Fredrik Barrenas, Sreenivas Chavali, Petter Holme, Reza Mobini, and Mikael BensonFrom:PLoS ONE (Vol. 4, Issue 11) Peer-Reviewed

  Nov. 30, 20093,999 words Article 1440LAuthor(s): Fredrik Barrenas 1,*, Sreenivas Chavali 1, Petter Holme 2,3, Reza Mobini 1, Mikael Benson 1 Introduction Systems Biology based approaches of studying human genetic diseases have brought in a shift in...

• Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement.

  Authors:Aleksandra Zielinska, Abigail Savietto, Anabela de Sousa Borges, Denis Martinez, Melanie Berbon, Joël R Roelofsen, et al.From:eLife (Vol. 9) Peer-Reviewed

  July 14, 202017,826 words Article 1460LThe bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. Current hypotheses suggest that...

• Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library.

  Authors:Thuy-Lan V Lite, Robert A Grant, Isabel Nocedal, Megan L Littlehale, Monica S Guo, and Michael T LaubFrom:eLife (Vol. 9) Peer-Reviewed

  Oct. 27, 202019,961 words Article 1430LProtein-protein interaction specificity is often encoded at the primary sequence level. However, the contributions of individual residues to specificity are usually poorly understood and often obscured by mutational...

• Identification of the hub gene BUB1B in hepatocellular carcinoma via bioinformatic analysis and in vitro experiments.

  Authors:Jie Fu, Xiao Zhang, Likun Yan, Yaoli Shao, Xinxu Liu, Yuan Chu, et al.From:PeerJ (Vol. 9) Peer-Reviewed

  Feb. 23, 20217,413 words Article 1240LBackground Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related deaths in the world. Although the treatment of HCC has made great progress in...

• Binding-Site Assessment by Virtual Fragment Screening

  Authors:Niu Huang and Matthew P. JacobsonFrom:PLoS ONE (Vol. 5, Issue 4) Peer-Reviewed

  Apr. 9, 20106,687 words Article 1540LThe accurate prediction of protein druggability (propensity to bind high-affinity drug-like small molecules) would greatly benefit the fields of chemical genomics and drug discovery. We have developed a novel approach...

• Nuclear Receptor CAR Represses TNF[alpha]-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

  Authors:Yukio Yamamoto, Rick Moore, Richard A. Flavell, Binfeng Lu, and Masahiko NegishiFrom:PLoS ONE (Vol. 5, Issue 4) Peer-Reviewed

  Apr. 12, 20105,244 words Article 1390LBackground Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC). PB activates nuclear xenobiotic receptor Constitutive...

• Comprehensive analysis of human microRNA target networks

  Authors:Jun-ichi Satoh and Hiroko TabunokiFrom:BioData Mining (Vol. 4) Peer-Reviewed

  June 17, 20114,750 words Report 1560LBackground MicroRNAs (miRNAs) mediate posttranscriptional regulation of protein-coding genes by binding to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or...

• Protein Networks Reveal Detection Bias and Species Consistency When Analysed by Information-Theoretic Methods

  Authors:Luis P. Fernandes, Alessia Annibale, Jens Kleinjung, Anthony C. C. Coolen, and Franca FraternaliFrom:PLoS ONE (Vol. 5, Issue 8) Peer-Reviewed

  Aug. 18, 20108,941 words Article 1580LWe apply our recently developed information-theoretic measures for the characterisation and comparison of protein-protein interaction networks. These measures are used to quantify topological network features via...

• Studying the Salt Dependence of the Binding of [sigma]70 and [sigma]32 to Core RNA Polymerase Using Luminescence Resonance Energy Transfer

  Authors:Bryan T. Glaser, Veit Bergendahl, Larry C. Anthony, Brian Olson, and Richard R. BurgessFrom:PLoS ONE (Vol. 4, Issue 8) Peer-Reviewed

  Aug. 3, 20098,480 words Article 1450LThe study of protein-protein interactions is becoming increasingly important for understanding the regulation of many cellular processes. The ability to quantify the strength with which two binding partners interact is...