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    Academic Journals

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• Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus

  Authors:Xiaohua Hou, Xiaoran Wang, and Liming ZhangFrom:Neurology India (Vol. 58, Issue 1) Peer-Reviewed

  January-February 20103,570 words Clinical report Byline: Xiaohua. Hou, Xiaoran. Wang, Liming. Zhang Backgroud : Brain-derived neurotrophic factor (BDNF) has been implicated as a potential therapeutic target in temporal lobe epilepsy (TLE). However, whether BDNF...

• GPI-anchored cell-surface molecules complexed to protein tyrosine kinases

  Authors:Irena Stefanova, Vaclav Horejsi, Ignacio J. Ansotegui, Walter Knapp, and Hannes StockingerFrom:Science (Vol. 254, Issue 5034) Peer-Reviewed

  Nov. 15, 19911,505 words Article Binding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by glycophosphatidylinositol (GPI) can cause activation of leukocytes. However, it is not known how these molecules, which...

• Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinase

  Authors:F.M. Uckun, W.E. Evans, C.J. Forsyth, K.G. Waddick, L.T. Ahlgren, L.M. Chelstrom, et al.From:Science (Vol. 267, Issue 5199) Peer-Reviewed

  Feb. 10, 19954,506 words Article B-cell precursor (BCP) leukemia is the most common form of childhood cancer and the second most common form of acute leukemia in adults. Human BCP leukemia was treated in a severe combined immunodeficient mouse model by...

• Bifurcation of lipid and protein kinase signals of PI3K gamma to the protein kinases PKB and MAPK

  Authors:Matthias P. Wymann, Tzvetanka Bondeva, and Luciano PirolaFrom:Science (Vol. 282, Issue 5387) Peer-Reviewed

  Oct. 9, 19981,905 words Article Phosphoinositide 3-kinases (PI3Ks) activate protein kinase PKB (also termed Akt), and PI3K[Gamma] activated by heterotrimeric guanosine triphosphate-binding protein can stimulate mitogen-activated protein kinase (MAPK)....

• Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity

  Authors:Yun Chen, Yao Guo, Jiayu Han, Wanting Tina Ho, Shibo Li, Xueqi Fu, et al.From:Journal of Hematology & Oncology (Vol. 5, Issue 1) Peer-Reviewed

  July 16, 20123,018 words Report 1380LBackground Gain-of-function mutations of tyrosine kinase FLT3 are frequently found in acute myeloid leukemia (AML). This has made FLT3 an important marker for disease diagnosis and a highly attractive target for...

• Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma (1)

  Authors:Melanie J. Chagnon, Mounib Elchebly, Noriko Uetani, Luce Dombrowski, Alan Cheng, Robert A. Mooney, et al.From:Canadian Journal of Physiology and Pharmacology (Vol. 84, Issue 7) Peer-Reviewed

  July 20065,698 words Article 1600LAbstract: Several protein tyrosine phosphatases (PTPs) expressed in insulin sensitive-tissues are proposed to attenuate insulin action and could act as key regulators of the insulin receptor (IR) signaling pathway....

• Locking out hepatitis C: hepatitis C virus puts about 130 million people worldwide at risk for severe liver disease, but no vaccine or broadly effective therapy yet exists. A new study identifies receptor tyrosine kinases as host factors required for hepatitis C virus entry--potentially opening the door for new antiviral strategies

  Authors:Gisa Gerold and Charles M. RiceFrom:Nature Medicine (Vol. 17, Issue 5) Peer-Reviewed

  May 20111,210 words Report 1450LViruses have evolved to use a collection of host factors to establish infection in their target organism. In the case of the blood-borne pathogen hepatitis C virus (HCV), much progress has been made in understanding how...

• Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

  Authors:Neil Stahl, Thomas J. Farruggella, Teri G. Boulton, Zhong Zhong, Jame E. Darnell, Jr., and George D. YancopoulosFrom:Science (Vol. 267, Issue 5202) Peer-Reviewed

  Mar. 3, 19953,119 words Article Many members of the cytokine receptor superfamily initiate intracellular signaling by activating members of the Jak family of tyrosine kinases. Activation of the same Jaks by multiple cytokines raises the question of how...

• BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance

  Authors:Hilmar Quentmeier, Sonja Eberth, Julia Romani, Margarete Zaborski, and Hans G. DrexlerFrom:Journal of Hematology & Oncology (Vol. 4) Peer-Reviewed

  Feb. 7, 20116,292 words Report 1300LBackground The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the...

• The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma.

  Authors:Cunzhen Shi, Xiangqun Li, Xiaogan Wang, Ning Ding, Lingyan Ping, Yunfei Shi, et al.From:Journal of Hematology & Oncology (Vol. 11, Issue 1) Peer-Reviewed

  Mar. 20, 20187,255 words Report 1490LBackground Mantle cell lymphoma (MCL) is an incurable B cell-derived malignant tumor with a median overall survival of 4-5 years. Mer tyrosine kinase (MerTK) has been reported to be aberrantly expressed in leukemia,...

• Up-front polytherapy for ALK-positive lung cancer.

  Authors:Bingying Zhou and Adrienne D. CoxFrom:Nature Medicine (Vol. 21, Issue 9) Peer-Reviewed

  Sept. 20151,321 words Article 1580LA new study identifies the RAS-MAPK pathway to be an Achilles' heel of EML4-ALK fusion-positive lung cancer and suggests that up-front combination therapy directed against both pathways can achieve sustained suppression...

• GITR expression on T-cell receptor-stimulated human CD8[sup]+ T cell in a JNK-dependent pathway

  Authors:Subhasis Chattopadhyay and Nitya ChakrabortyFrom:Indian Journal of Human Genetics (Vol. 15, Issue 3) Peer-Reviewed

  September-December 20091,918 words Report Byline: Subhasis. Chattopadhyay, Nitya. Chakraborty Glucocorticoid-induced tumor necrosis factor receptor (TNFR) (GITR) family-related gene is a member of the TNFR super family. GITR works as one of the...

• Interaction of IL-2RBeta and GammaC chains with Jak1 and Jak3: implications for XSCID and XCID

  Authors:Sarah M. Russell, James A. Johnston, Masayuki Noguchi, Masaru Kawamura, Chris M. Bacon, Michael Friedmann, et al.From:Science (Vol. 266, Issue 5187) Peer-Reviewed

  Nov. 11, 19942,220 words Article Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor [beta] (IL-2R[beta]) and common [gamma] ([[gamma].sub.c]) chains. Mutations of [[gamma].sub.c] can result in X-linked severe combined...

• Requirement for tyrosine kinase p56ick for thymic development of transgenic gamma delta T cells

  Authors:Josef Penninger, Kenji Kishihara, Thierry Molina, Valeria Wallace, Emma Timms, STEphen M. Hedrick, et al.From:Science (Vol. 260, Issue 5106) Peer-Reviewed

  Apr. 16, 19932,142 words Article The Src-related protein tyrosine kinase [p56.sup.lck] is essential for antigen-specific signal transduction and thymic maturation of T cells that have an [alpha][beta] T cell receptor (TCR), presumably by physical...

• Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit

  Authors:Hisashi Uemeori, Takafumi Inoue, Shoen Kume, Naohiro Sekiyama, Motoshi Nagao, Hiroshi Itoh, et al.From:Science (Vol. 276, Issue 5320) Peer-Reviewed

  June 20, 19971,719 words Article Various receptors coupled to the heterotrimeric guanine nucleotide-binding protein Gq/11 stimulate formation of inositol-1,4,5-trisphosphate ([IP.sub.3]). Activation of these receptors also induces protein tyrosine...

• A dimerization-dependent mechanism drives RAF catalytic activation

  Authors:Thanashan Rajakulendran, Malha Sahmi, Martin Lefrancois, Frank Sicheri, and Marc TherrienFrom:Nature (Vol. 461, Issue 7263) Peer-Reviewed

  Sept. 24, 20094,097 words Report 1500LThe ERK (extracellular signal-regulated kinase) pathway is an evolutionarily conserved signal transduction module that controls cellular growth, differentiation and survival'. Activation of receptor tyrosine kinases...

• In vivo role of focal adhesion kinase in regulating pancreatic [beta]-cell mass and function through insulin signaling, actin dynamics, and granule trafficking

  Authors:Erica P. Cai, Marina Casimir, Stephanie A. Schroer, Cynthia T. Luk, Sally Yu Shi, Diana Choi, et al.From:Diabetes (Vol. 61, Issue 7) Peer-Reviewed

  July 20126,017 words Report 1530LFocal adhesion kinase (FAK) acts as an adaptor at the focal contacts serving as a junction between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a determinant step in insulin secretion....

• Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines

  Authors:Cornel Joseph Phillip, Shadia Zaman, Shujun Shentu, Kumudha Balakrishnan, Jiexin Zhang, Veera Baladandayuthapani, et al.From:Journal of Hematology & Oncology (Vol. 6, Issue 1) Peer-Reviewed

  Dec. 10, 20139,380 words Report 1520LBackground MET is a receptor tyrosine kinase that is activated by the ligand HGF and this pathway promotes cell survival, migration, and motility. In accordance with its oncogenic role, MET is constitutively active,...

• PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

  Authors:Ryoichi Banno, Derek Zimmer, Bart C. De Jonghe, Marybless Atienza, Kimberly Rak, Wentian Yang, et al.From:Journal of Clinical Investigation (Vol. 120, Issue 3) Peer-Reviewed

  Mar. 201010,349 words Report 1420LProtein tyrosine phosphatase 1B (PTP1B) and SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) have been shown in mice to regulate metabolism via the central nervous system, but the specific neurons mediating...

• BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B Cells

  Authors:Uckun, Fatih, M., Kevin G. Waddick, Sandeep Mahajan, Xioa Jun, Minoru Takata, Joseph Bolen, et al.From:Science (Vol. 273, Issue 5278) Peer-Reviewed

  Aug. 23, 19963,965 words Article Bruton's tyrosine kinase (BTK) is a member of the SRC-related TEC famity of proten' tyrosine kinases (PTKs). DT-40 lymphoma B cells, rendered BTK-deficient through targeted disruption of the btk gene by homologous...