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Academic Journals
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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedThe rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a...
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From:PLoS ONE (Vol. 6, Issue 10) Peer-ReviewedBackground Ankrd2 (also known as Arpp) together with Ankrd1/CARP and DARP are members of the MARP mechanosensing proteins that form a complex with titin (N2A)/calpain 3 protease/myopalladin. In muscle, Ankrd2 is...
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From:PLoS ONE (Vol. 7, Issue 12) Peer-ReviewedAuthor(s): Caitlyn W. Barrett 1 , 2 , J. Joshua Smith 6 , Lauren C. Lu 4 , Nicholas Markham 2 , Kristy R. Stengel 3 , Sarah P. Short 2 , Baolin Zhang 1 , 2 , Aubrey A. Hunt 3 , Barbara M. Fingleton 2 , 7 , Robert H....
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From:PLoS ONE (Vol. 10, Issue 4) Peer-ReviewedTumor-associated macrophages (TAMs) are involved in tumor progression by promoting epithelial-mesenchymal transition (EMT), tumor cell invasion, migration and angiogenesis. However, in breast cancer, the clinical...
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From:PLoS ONE (Vol. 8, Issue 12) Peer-ReviewedYeast two-hybrid (Y2H) methods are powerful tools for detecting protein-protein interactions. The traditional Y2H method has been widely applied to screen novel protein interactions since it was established two decades...
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From:PLoS ONE (Vol. 6, Issue 8) Peer-ReviewedHuntington's disease (HD) is caused by the expansion of N-terminal polymorphic poly Q stretch of the protein huntingtin (HTT). Deregulated microRNAs and loss of function of transcription factors recruited to mutant HTT...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2016) Peer-ReviewedLung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently needed. Several diseases including lung...
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From:PLoS ONE (Vol. 5, Issue 10) Peer-ReviewedEnhanced understanding of differential gene expression and biological pathways associated with distinct phases of intramembranous bone regeneration following femoral marrow ablation surgery will improve future...
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From:PLoS ONE (Vol. 6, Issue 10) Peer-ReviewedMaster regulator protein p53, popularly known as the "guardian of genome" is the hub for regulation of diverse cellular pathways. Depending on the cell type and severity of DNA damage, p53 protein mediates cell cycle...
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From:Indian Journal of Dental Advancements (Vol. 2, Issue 1) Peer-ReviewedTumour markers are substances that are produced either by the tumour itself or by the body in response to the presence of cancer or certain benign conditions that can aid in the diagnosis of cancer. the subject of...
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From:PLoS ONE (Vol. 6, Issue 6) Peer-ReviewedThe tumor suppressor gene p53 is mutated or deleted in over 50% of human tumors. As functional p53 plays a pivotal role in protecting against cancer development, several strategies for restoring wild-type (wt) p53...
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From:Expert Review of Molecular Diagnostics (Vol. 4, Issue 2) Peer-ReviewedIn this second part of the two-part review of breast cancer biomarkers and molecular medicine, the first section will consider additional breast cancer prognostic factors, including oncogenes, tumor suppressor genes,...
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From:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewedp53 is one of the most well studied tumor suppressor proteins and regarded as the guardian of the genome. The protein mediates cell-cycle arrest, apoptosis in response to myriads of cellular stresses including DNA...
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From:PLoS ONE (Vol. 5, Issue 11) Peer-ReviewedBackground BORIS/CTCFL is a paralogue of CTCF, the major epigenetic regulator of vertebrate genomes. BORIS is normally expressed only in germ cells but is aberrantly activated in numerous cancers. While recent...
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From:PLoS ONE (Vol. 3, Issue 11) Peer-ReviewedBackground The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation,...
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From:PLoS ONE (Vol. 6, Issue 11) Peer-ReviewedMiR-34a acts as a candidate tumour suppressor gene, and its expression is reduced in several cancer types. We aimed to study miR-34a expression in breast cancer and its correlation with tumour characteristics and...
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From:PLoS ONE (Vol. 7, Issue 10) Peer-ReviewedThe tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding...
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From:PLoS ONE (Vol. 9, Issue 3) Peer-ReviewedAuthor(s): Suiquan Wang 1, Miaoni Zhou 1, Fuquan Lin 1, Dongyin Liu 1, Weisong Hong 1, Liangjun Lu 1,2, Yiping Zhu 1,2, Aie Xu 1,* Introduction The loss of melanocytes is the cause of skin de-pigmentation in...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedBackground Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of...
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From:PLoS ONE (Vol. 8, Issue 9) Peer-ReviewedSALL2- a member of the Spalt gene family- is a poorly characterized transcription factor found deregulated in various cancers, which suggests it plays a role in the disease. We previously identified SALL2 as a novel...