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    Academic Journals

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• Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases

  Authors:Chih-Jung Kuo, Rey-Ting Guo, I.-Lin Lu, Hun-Ge Liu, Su-Ying Wu, Tzu-Ping Ko, et al.From:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20083,405 words Report Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation...

• Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism

  Authors:Shannon E. Hill, Elaine Nguyen, Chiamaka U. Ukachukwu, Dana M. Freeman, Stephen Quirk, and Raquel L. LiebermanFrom:PLoS ONE (Vol. 12, Issue 7) Peer-Reviewed

  July 25, 20176,863 words Report 1510LDihydroneopterin triphosphate pyrophosphatase (DHNTPase), a member of the Mg.sup.2+ dependent Nudix hydrolase superfamily, is the recently-discovered enzyme that functions in the second step of the pterin branch of the...

• Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C

  Authors:Tomoo Yamazaki, Satoru Joshita, Takeji Umemura, Yoko Usami, Ayumi Sugiura, Naoyuki Fujimori, et al.From:PLoS ONE (Vol. 13, Issue 4) Peer-Reviewed

  Apr. 4, 20185,350 words Report 1460LSustained virological response (SVR) rates have increased remarkably since the introduction of direct-acting antiviral agents (DAAs) for chronic hepatitis C. Autotaxin (ATX) is a secreted enzyme converting...

• Photosynthetic conversion of CO2 to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria

  Authors:Sun Young Choi, Hyun Jeong Lee, Jaeyeon Choi, Jiye Kim, Sang Jun Sim, Youngsoon Um, et al.From:Biotechnology for Biofuels (Vol. 9, Issue 1) Peer-Reviewed

  Sept. 22, 20167,688 words Report 1560LBackground Metabolic engineering of cyanobacteria has enabled photosynthetic conversion of CO.sub.2 to value-added chemicals as bio-solar cell factories. However, the production levels of isoprenoids in engineered...

• Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

  Authors:Delphine Goubau, Martin Schlee, Safia Deddouche, Andrea J. Pruijssers, Thomas Zillinger, Marion Goldeck, et al.From:Nature (Vol. 514, Issue 7522) Peer-Reviewed

  Oct. 16, 20148,214 words Article 1510LAuthor(s): Delphine Goubau (corresponding author) [1, 7]; Martin Schlee [2, 7]; Safia Deddouche [1, 8]; Andrea J. Pruijssers [3, 4]; Thomas Zillinger [2]; Marion Goldeck [2]; Christine Schuberth [2]; Annemarthe G. Van...

• Exploring the effect of melamine pyrophosphate and aluminum hypophosphite on flame retardant wood flour/polypropylene composites

  Authors:Panpan Zhao, Chuigen Guo, and Liping LiFrom:Construction and Building Materials (Vol. 170) Peer-Reviewed

  May 10, 20183,678 words Report, Statistical ... 1680LABSTRACT In this examine, melamine pyrophosphate (MPP) and aluminum hypophosphite (AHP) were selected as flame retardants. The synergistic effect between the MPP and AHP on flame retardancy and thermal stability of...

• Pyrophosphate modulates plant stress responses via SUMOylation

  Authors:M Gorkem Patir-Nebioglu, Zaida Andres, Melanie Krebs, Fabian Fink, Katarzyna Drzewicka, Nicolas Stankovic-Valentin, et al.From:eLife (Vol. 8) Peer-Reviewed

  Feb. 20, 201914,172 words Report 1440LPyrophosphate (PPi), a byproduct of macromolecule biosynthesis is maintained at low levels by soluble inorganic pyrophosphatases (sPPase) found in all eukaryotes. In plants, H.sup.+-pumping pyrophosphatases...

• Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders

  Authors:Julie Mollet, Irina Giurgea, Dimitri Schlemmer, Gustav Dallner, Dominique Chretien, Agnes Delahodde, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20074,330 words Article 1370LCoenzyme [Q.sub.10] (Co[Q.sub.10]) plays a pivotal role in oxidative phosphorylation (OXPHOS), as it distributes electrons among the various dehydrogenases and the cytochrome segments of the respiratory chain. We have...

• Solid-state defect mechanism in vanadyl pyrophosphate catalysts: implications for selective oxidation

  Authors:Pratibha L. Gai and K. KourtakisFrom:Science (Vol. 267, Issue 5198) Peer-Reviewed

  Feb. 3, 19952,414 words Article High-resolution and in situ electron microscopy of vanadyl pyrophosphate catalysts reacted in alkane (n-butane) and other reducing environments have shown evidence for surface structure modifications accompanied by two...

• Crystal shape, size distinguish types of gout

  Author:Diana MahoneyFrom:Family Practice News (Vol. 37, Issue 20)

  Oct. 15, 2007388 words Brief article 1480LBOSTON -- To differentiate definitively between acute gout and pseudogout, look at the crystals. On UV light microscopy, fluid aspirated from the inflamed joint of a patient with pseudogout will be teeming with...

• Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis

  Authors:Atiqah Subki, Chai Ling Ho, Nur Farhah Nabihan Ismail, Aisamuddin Ardi Zainal Abidin, and Zetty Norhana Balia YusofFrom:PLoS ONE (Vol. 15, Issue 7) Peer-Reviewed

  July 29, 20207,824 words Report 1470LAuthor(s): Atiqah Subki 1, Chai Ling Ho 2, Nur Farhah Nabihan Ismail 3, Aisamuddin Ardi Zainal Abidin 1,3, Zetty Norhana Balia Yusof 1,3,4,* Introduction Thiamine (Vitamin B1 ) is a necessary microelement merited...

• Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice

  Authors:Jian Yang, Chen-Ze Zhao, Bin Chen, Fei Chen, Jie Han, and Shen-Jiang HuFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20153,136 words Report 1400LFarnesyl pyrophosphate synthase (FPPS) plays a vital role in the mevalonate pathway and has been shown to be involved in hypertrophy and cardiovascular diseases. Lentivirus-mediated RNA interference (RNAi) to knock down...

• Phosphoribosyl pyrophosphate formation in the rat adrenal gland in relation to adrenal growth in experimental diabetes

  Authors:Sirilaksana Kunjara, Milena Sochor, Salah Ahmed, A. Leslie Greenbaum, and Patricia McLeanFrom:Diabetes (Vol. 41, Issue 11) Peer-Reviewed

  Nov. 19925,082 words Article Adrenal growth occurs in experimental diabetes, and evidence exists for increased adrenal function. The concentration of PPRibP has been examined in the rat adrenal gland at various times after induction of diabetes...

• Experience with using fosfestrol for treating metastatic castrate-resistant prostate cancer in resource-limited setting

  Authors:Jayachandran Kalaiyarasi, Venkatraman Radhakrishnan, Trivadi Ganesan, Anand Raja, Prasanth Ganesan, Manikandan Dhanushkodi, et al.From:Indian Journal of Medical and Paediatric Oncology (Vol. 40, Issue 1) Peer-Reviewed

  January-March 20192,377 words Report 1430LByline: Jayachandran. Kalaiyarasi, Venkatraman. Radhakrishnan, Trivadi. Ganesan, Anand. Raja, Prasanth. Ganesan, Manikandan. Dhanushkodi, Tenali. Sagar Background: Fosfestrol is a low-cost estrogen analog that is...

• Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice

  Authors:Daniel Caballero, Yuwen Li, Jonathan Fetene, Julian Ponsetto, Alyssa Chen, Chuanlong Zhu, et al.From:PLoS ONE (Vol. 12, Issue 7) Peer-Reviewed

  July 13, 20176,078 words Report 1620LMutations in the proximal tubular sodium-dependent phosphate co-transporters NPT2a and NPT2c have been reported in patients with renal stone disease and nephrocalcinosis, however the relative contribution of genotype,...

• Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity.

  Authors:Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, David Patterson, et al.From:PLoS ONE (Vol. 16, Issue 7) Peer-Reviewed

  July 20, 20218,739 words Report 1440LIn humans, GART [phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) / phosphoribosylglycinamide synthetase (EC 6.3.4.13) / phosphoribosylaminoimidazole synthetase (EC 6.3.3.1)] is a trifunctional protein which...

• The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal

  Authors:Atilio Deana, Helena Celesnik, and Joel G. BelascoFrom:Nature (Vol. 451, Issue 7176) Peer-Reviewed

  Jan. 17, 20084,985 words Report Author(s): Atilio Deana [1]; Helena Celesnik [1]; Joel G. Belasco (corresponding author) [1] The long-standing assumption that messenger RNA (mRNA) degradation in Escherichia coli begins with endonucleolytic cleavage...

• Pyrophosphate and orthophosphate addition to soils: sorption, cation concentrations, and dissolved organic carbon

  Authors:T.M. McBeath, E. Lombi, M.J. McLaughlin, and E.K. BunemannFrom:Australian Journal of Soil Research (Vol. 45, Issue 4) Peer-Reviewed

  June 20074,414 words Article 1490LLiquid polyphosphate fertilisers contain both orthophosphate and pyrophosphate, and have shown significant yield increases compared to granular orthophosphate fertiliser on highly phosphorus (P) fixing soils. The P...

• Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation

  Authors:Emine Cinici, Ibrahim Ahiskali, Nihal Cetin, Bahadir Suleyman, Osman Kukula, Durdu Altuner, et al.From:Indian Journal of Ophthalmology (Vol. 64, Issue 6) Peer-Reviewed

  June 20164,199 words Report 1700LByline: Emine. Cinici, Ibrahim. Ahiskali, Nihal. Cetin, Bahadir. Suleyman, Osman. Kukula, Durdu. Altuner, Abdulkadir. Coban, Hilal. Balta, Mehmet. Kuzucu, Halis. Suleyman Purpose: Information is lacking on the...

• Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy

  Authors:Keith L. Keene, Josyf C. Mychaleckyj, Shelly G. Smith, Tennille S. Leak, Peter S. Perlegas, Carl D. Langefeld, et al.From:Diabetes (Vol. 57, Issue 4) Peer-Reviewed

  Apr. 20084,522 words Clinical report 1600LOBJECTIVE--Variants in the ectonucleotide pyrophosphatase/ phosphodiesterase 1 (ENPP1) gene have shown positive associations with diabetes and related phenotypes, including insulin resistance, metabolic syndrome, and...