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    Academic Journals

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• High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of novel RNA polymerase II-associated chaperone

  Authors:P. Cloutier, R. Al- Khoury, M. Lavelle-Adam, D. Faubert, H. Jiang, C. Poitras, et al.From:Biochemistry and Cell Biology (Vol. 88, Issue 2) Peer-Reviewed

  Apr. 2010243 words Brief article, Repor... 1620LNumerous reports have described how RNA polymerase II (RNAPII) enacts transcription of protein-coding genes and how this enzyme is regulated by a variety of cues, but, paradoxically, little is known about the assembly...

• Myxopyronin: a punch in the jaws of bacterial RNA polymerase

  Authors:Audrey Tupin, Maxime Gualtieri, Konstantin Brodolin, and Jean-Paul LeonettiFrom:Future Microbiology (Vol. 4, Issue 2)

  Mar. 20092,554 words Report Author(s): Audrey Tupin 1 , Maxime Gualtieri 2 , Konstantin Brodolin 3 , Jean-Paul Leonetti [[dagger]] 4 The growing challenge of antimicrobial resistance and the scarcity of novel antibiotics with new mechanisms of...

• Recombinant nematode anticoagulant protein c2 in non-ST segment elevation acute coronary syndrome and beyond

  Authors:Adrian Fluture, Gregory R Giugliano, and Robert P GiuglianoFrom:Future Cardiology (Vol. 3, Issue 4) Peer-Reviewed

  July 20076,797 words Drug overview Author(s): Adrian Fluture 1 , Gregory R Giugliano 2 , Robert P Giugliano [[dagger]] 3 Keywords: acute coronary syndrome; anticoagulant; myocardial infarction; tissue factor; thrombosis Cardiovascular disease is...

• Consequences of replication fork movement through transcription units in vivo

  Author:Sarah FrenchFrom:Science (Vol. 258, Issue 5086) Peer-Reviewed

  Nov. 20, 19922,875 words Article To examine the basis for the evolutionary selection for codirectionality of replication and transcription in Escherichia coli, electron microscopy was used to visualize replication from an inducible ColE1 replication...

• Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex

  Authors:Bin Liu and Bruce M. AlbertsFrom:Science (Vol. 267, Issue 5201) Peer-Reviewed

  Feb. 24, 19955,646 words Article An in vitro system reconstituted from purified proteins has been used to examine what happens when the DNA replication apparatus of bacteriophage T4 collides with an Escherichia coli RNA polymerase ternary transcription...

• T7 RNA Polymerase Functions In Vitro without Clustering

  Authors:Kieran Finan, Joseph P. Torella, Achillefs N. Kapanidis, and Peter R. CookFrom:PLoS ONE (Vol. 7, Issue 7) Peer-Reviewed

  July 2, 20129,689 words Article 1500LAuthor(s): Kieran Finan 1 , Joseph P. Torella 2 , Achillefs N. Kapanidis 2 , Peter R. Cook 1 , * Introduction Mounting evidence suggests that many RNA and DNA polymerases function in clusters rather than in...

• Inter- and Intra-Host Viral Diversity in a Large Seasonal DENV2 Outbreak

  Authors:Camila Malta Romano, Michael Lauck, Felipe S. Salvador, Celia Rodrigues Lima, Lucy S. Villas-Boas, Evaldo Stanislau A. Araujo, et al.From:PLoS ONE (Vol. 8, Issue 8) Peer-Reviewed

  Aug. 2, 20137,089 words Article 1600LAuthor(s): Camila Malta Romano 1,*, Michael Lauck 2, Felipe S. Salvador 1, Célia Rodrigues Lima 1, Lucy S. Villas-Boas 1, Evaldo Stanislau A. Araújo 3, José Eduardo Levi 1, Claudio Sergio Pannuti 1, David O'Connor 2,...

• The 5' Spreading of Small RNAs in Dictyostelium discoideum Depends on the RNA-Dependent RNA Polymerase RrpC and on the Dicer-Related Nuclease DrnB

  Authors:Stephan Wiegand and Christian HammannFrom:PLoS ONE (Vol. 8, Issue 5) Peer-Reviewed

  May 20, 20136,922 words Article 1560LAuthor(s): Stephan Wiegand, Christian Hammann * Introduction Double stranded RNA is the central nucleic acid entity in the gene regulatory mechanism RNA interference (RNAi) [1] that acts in many eukaryotes....

• Core Mediator structure at 3.4 extends model of transcription initiation complex

  Authors:Kayo Nozawa, Thomas R. Schneider, and Patrick CramerFrom:Nature (Vol. 545, Issue 7653) Peer-Reviewed

  May 11, 20175,743 words Report 1370LAuthor(s): Kayo Nozawa [1]; Thomas R. Schneider [2]; Patrick Cramer (corresponding author) [1] Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA...

• A Marvellous Machine for Making Messages

  Author:Aaron KlugFrom:Science (Vol. 292, Issue 5523) Peer-Reviewed

  June 8, 20011,904 words Article The multisubunit enzyme RNA polymerase II (also called RNA polymerase b, Rpb, or Pol II) is the central enzyme of gene expression in eukaryotes. It reads the sequence of one strand of the DNA double helix (the template)...

• New insights into the biogenesis of nuclear RNA polymerases?

  Authors:Philippe Cloutier and Benoit CoulombeFrom:Biochemistry and Cell Biology (Vol. 88, Issue 2) Peer-Reviewed

  Apr. 20107,964 words Report 1480LMore than 30 years of research on nuclear RNA polymerases (RNAP I, II, and III) has uncovered numerous factors that regulate the activity of these enzymes during the transcription reaction. However, very little is known...

• Studying the Salt Dependence of the Binding of [sigma]70 and [sigma]32 to Core RNA Polymerase Using Luminescence Resonance Energy Transfer

  Authors:Bryan T. Glaser, Veit Bergendahl, Larry C. Anthony, Brian Olson, and Richard R. BurgessFrom:PLoS ONE (Vol. 4, Issue 8) Peer-Reviewed

  Aug. 3, 20098,480 words Article 1450LThe study of protein-protein interactions is becoming increasingly important for understanding the regulation of many cellular processes. The ability to quantify the strength with which two binding partners interact is...

• Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance

  Authors:Sung Hyun Ahn, Doo Hyun Kim, Ah Ram Lee, Beom Kyung Kim, Yong Kwang Park, Eun-Sook Park, et al.From:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 31, 20156,217 words Report 1420LThe emergence of compensatory mutations in the polymerase gene of drug resistant hepatitis B virus (HBV) is associated with treatment failure. We previously identified a multi-drug resistant HBV mutant, which displayed...

• Differential Expression of Tomato Spotted Wilt Virus-Derived Viral Small RNAs in Infected Commercial and Experimental Host Plants

  From:PLoS ONE (Vol. 8, Issue 10) Peer-Reviewed

  Oct. 15, 20139,659 words Article 1600LBackground Viral small RNAs (vsiRNAs) in the infected host can be generated from viral double-stranded RNA replicative intermediates, self-complementary regions of the viral genome or from the action of host...

• Studies on Transcriptional Incorporation of 5'-N-Triphosphates of 5'-Amino-5'-Deoxyribonucleosides

  Authors:Weronika Kotkowiak, Anna Pasternak, and Ryszard KierzekFrom:PLoS ONE (Vol. 11, Issue 2) Peer-Reviewed

  Feb. 1, 20165,390 words Report 1320LIn this study, several RNA polymerases were used for the first time to examine the possibility of transcriptional incorporation of 5'-N-triphosphates of 5'-amino-5'-deoxyribonucleosides (5'NH NTPs). The T3, T7, Sp6 and...

• Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete

  Authors:William K. Arnold, Christina R. Savage, Kathryn G. Lethbridge, Trever C. Smith, Catherine A. Brissette, Janakiram Seshu, et al.From:PLoS ONE (Vol. 13, Issue 8) Peer-Reviewed

  Aug. 30, 201812,922 words Report 1510LBorrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle that alternates between ticks and vertebrates. To facilitate this defined lifestyle, B. burgdorferi has evolved a gene...

• Structure of transcribing mammalian RNA polymerase II.

  Authors:Carrie Bernecky, Franz Herzog, Wolfgang Baumeister, Jürgen M. Plitzko, and Patrick CramerFrom:Nature (Vol. 529, Issue 7587) Peer-Reviewed

  Jan. 28, 20168,795 words Report 1510LThe first high-resolution, cryo-electron microscopy structure of mammalian RNA polymerase II, in the form of a transcribing complex comprising DNA template and RNA transcript. Mammalian RNA polymerase II structure...

• Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila

  Authors:Harsh H. Kavi and James A. BirchlerFrom:Epigenetics & Chromatin (Vol. 2) Peer-Reviewed

  Nov. 16, 20097,512 words Report Authors: Harsh H Kavi [1]; James A Birchler (corresponding author) [1] Background The metazoan chromosome consists of two distinct functional compartments based mainly on their transcriptional competence and...

• Requirement of Tissue-Selective TBP-Associated Factor [TAF.sub.II]105 in Ovarian Development

  Authors:Richard N. Frieman, Shane R. Albright, Shuang Zheng, William C. Sha, Robert E. Hammer, and Robert TjianFrom:Science (Vol. 293, Issue 5537) Peer-Reviewed

  Sept. 14, 20013,183 words Article Transcription factor TFIID, composed of TBP and [TAF.sub.II] subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective [TAF.sub.II]105 subunit of TFIID is essential...

• When a part is as good as the whole

  Authors:Pieter L. deHaseth and Timothy W. NilsenFrom:Science (Vol. 303, Issue 5662) Peer-Reviewed

  Feb. 27, 20041,172 words Article 1520LRNA polymerase is one of the largest (molecular mass, 470 kD) and most complex enzymes in bacteria. This enzyme is capable of catalyzing the synthesis of all messenger RNAs, ribosomal RNAs, and transfer RNAs. The...