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From:Diabetes (Vol. 44, Issue 4) Peer-ReviewedHuman proinsulin and 32-33 split proinsulin have been measured in the peripheral circulation by immunoradiometric assays (IRMAS) and have been shown to be elevated in impaired glucose tolerance and non-insulin-dependent...
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From:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 74, Issue 9) Peer-ReviewedBackground: Some multiple sclerosis (MS) patients treated with interferon beta (IFN [beta]) develop antibodies to the drug. Neutralising antibody (NAB) assays for IFN [beta] are expensive and the clinical relevance of...
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From:Annals of the Rheumatic Diseases (Vol. 61, Issue 12) Peer-ReviewedObjective: To compare test characteristics of the Farr radioimmunoassay and an automated fluorescence immunoassay (ELIA dsDNA test) for the diagnosis of systemic lupus erythematosus (SLE). Methods: A cross sectional...
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From:PLoS ONE (Vol. 13, Issue 12) Peer-ReviewedThe [alpha]7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune target. Here, we describe a new radioimmunoassay (RIA)...
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From:Diabetes (Vol. 38, Issue 7) Peer-ReviewedInsulin antibodies were not detected in an insulin-capture enzyme-linked immunosorbent assay (ELISA), but they were easily detected in an insulin-copolymer-capture ELISA. Thus, there is a high degree of steric hindrance...
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From:Neurology India (Vol. 58, Issue 3) Peer-ReviewedByline: Hamid. Suhail, Christhunesa. Soundararajan, Subbiah. Vivekanandhan, Sumit. Singh, Madhuri. Behari Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in...
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From:Gut (Vol. 48, Issue 1) Peer-ReviewedAbstract Background--The relationship between plasma gastrin levels and colorectal cancer is controversial. When confounding factors which increase plasma gastrin levels are taken into account, it has been shown that...
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From:Journal of Research in Medical Sciences (Vol. 21, Issue 1) Peer-ReviewedByline: Kun-Bin. Li, Xian-Li. Yao, Ping-Ge. Sun, Zhi-Yuan. Wu, Xiao-Xing. Li, Jun-Qi. Liu, Yi-Lan. Li Background: To investigate the relation between serum leptin levels and cerebral infarction (CI) by meta-analysis....
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From:Indian Journal of Medical Sciences (Vol. 66, Issue 7) Peer-ReviewedByline: Denise. Leite, Ricardo. Meirelles, Carlos. Mandarim-De-Lacerda, Haroldo. Matos, Sebastiao. Santos-Filho, Mario. Bernardo-Filho Background: Serum levels of total insulin-like growth factor I (IGF-I) reflect...
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From:Journal of Family Practice (Vol. 57, Issue 4) Peer-ReviewedFrom the Family Physicians Inquiries Network Evidence-based answer First, establish that true hypercalcemia exists by repeating the serum calcium and measuring or calculating the physiologically active serum...
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From:Diabetes (Vol. 41, Issue 1) Peer-ReviewedThe vascular order of pancreatic islet cellular perfusion is important in the intraislet regulation of hormone secretion. Establishment of the sequence of interaction is fundamental to understanding the physiology and...
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From:PLoS ONE (Vol. 12, Issue 3) Peer-ReviewedObjective The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. Study design Progesterone, estradiol, estriol and...
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From:Diabetes (Vol. 38, Issue 10) Peer-ReviewedAn important part of the body's defense system is the production of natural substances called antibodies to inactivate specific foreign particles called antigens. Under abnormal conditions, these inactivating substances...
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From:Expert Review of Molecular Diagnostics (Vol. 2, Issue 1) Peer-ReviewedFujirebio Diagnostics, Inc. (FDI), formerly known as Centocor Diagnostics, is to begin marketing a new line of six enzyme immunoassays (EIAs) in microtiter format. The new EIAs will be based on the same 'gold standard'...
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From:Diabetes (Vol. 41, Issue 9) Peer-ReviewedRIA methodology is used widely to measure proinsulin in human serum. However, some RIAs lack the sensitivity necessary to quantify proinsulin in unextracted serum and require long incubation periods. We developed an RIA...
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From:Science (Vol. 228) Peer-ReviewedThe cytochromes P-450 are major enzymes for the metabolism of xenobiotics, such as drugs and carcinogens, as well as for certain classes of endobiotics, including steroids and prostaglandins (1). The cytochrome...
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From:Forensic Science International (Vol. 159, Issue 2-3) Peer-ReviewedAbstract In forensics and archaeology, it is important to distinguish human from animal remains and to identify animal species from fragmentary bones and bloodstains. We report blind tests in which a protein...