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• Select Liver hormone

  1

  Liver hormone

  From:Nature Medicine (Vol. 16, Issue 12) Peer-Reviewed

  Dec. 201057 words Brief article 1780LNov 3 The liver hormone selenoprotein P (seP) may function as another culprit behind insulin resistance. Researchers found that administering purified seP impaired insulin signaling in human liver and muscle cells,...
• Select Translational regulation of GPx-1 and GPx-4 by the mTOR pathway

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  Translational regulation of GPx-1 and GPx-4 by the mTOR pathway

  Authors:Emily N. Reinke, Dede N. Ekoue, Soumen Bera, Nadim Mahmud, and Alan M. DiamondFrom:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20144,977 words Report 1610LGlutathione peroxidase activity was previously determined to be elevated in lymphocytes obtained from patients treated with the Bcr-Abl kinase inhibitor imatinib mesylate. In order to expand upon this observation, the...
• Select Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

  3

  Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

  Authors:Lili Men, Juan Sun, and Decheng RenFrom:Cellular Physiology and Biochemistry (Vol. 51, Issue 5) Peer-Reviewed

  Dec. 1, 20185,777 words Report 1400LBackground/Aims: VCP-interacting membrane selenoprotein (VIMP), an ER resident selenoprotein, is highly expressed in [beta]-cells, however, the role of VIMP in [beta]-cells has not been characterized. In this study, we...
• Select Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice

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  Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice

  Authors:Marsha N. Blauwkamp, Jingcheng Yu, MaryLee A. Schin, Kathleen A. Burke, Marla J. Berry, Bradley A. Carlson, et al.From:BMC Nephrology (Vol. 9) Peer-Reviewed

  July 22, 20084,105 words Article 1390LBackground Selenoproteins contain selenocysteine (Sec), commonly considered the 21.sup.st .sup.genetically encoded amino acid. Many selenoproteins, such as the glutathione peroxidases and thioredoxin reductases,...
• Select The syndrome of inherited partial SBP2 deficiency in humans

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  The syndrome of inherited partial SBP2 deficiency in humans

  Authors:Alexandra M. Dumitrescu, Caterina Di Cosmo, Xiao-Hui Liao, Roy E. Weiss, and Samuel RefetoffFrom:Antioxidants & Redox Signaling (Vol. 12, Issue 7) Peer-Reviewed

  Apr. 1, 201011,185 words Report Selenium (Se) is an essential trace element required for the biosynthesis of selenoproteins. Selenocysteine insertion sequence (SECIS) binding protein 2 (SBP2) represents a key trans-acting factor for the...
• Select Genetic variation in selenoprotein S influences inflammatory response

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  Genetic variation in selenoprotein S influences inflammatory response

  Authors:Joanne E Curran, Jeremy B M Jowett, Kate S Elliott, Yuan Gao, Kristi Gluschenko, Jianmin Wang, et al.From:Nature Genetics (Vol. 37, Issue 11) Peer-Reviewed

  Nov. 20058,132 words Article 1520LChronic inflammation has a pathological role in many common diseases and is influenced by both genetic and environmental factors. Here we assess the role of genetic variation in selenoprotein S (SEPS1, also called SELS...
• Select A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

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  A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

  Authors:Colleen Carmody, Ashley N. Ogawa-Wong, Cecilia Martin, Cristina Luongo, Marian Zuidwijk, Benjamin Sager, et al.From:Endocrinology (Vol. 160, Issue 5) Peer-Reviewed

  May 201910,375 words Report 1570LThe type 2 iodothyronine-deiodinase (D2) enzyme converts [T.sub.4] to [T.sub.3], and mice deficient in this enzyme [D2 knockout (D2KO) mice] have decreased [T.sub.3] derived from [T.sub.4] in skeletal muscle despite...
• Select Lack of Association between Common Polymorphisms in Selenoprotein P Gene and Susceptibility to Colorectal Cancer, Breast Cancer, and Prostate Cancer: A Meta-Analysis.

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  Lack of Association between Common Polymorphisms in Selenoprotein P Gene and Susceptibility to Colorectal Cancer, Breast Cancer, and Prostate Cancer: A Meta-Analysis.

  Authors:Hanjiang Xu, Fan Mo, Jun Zhou, Zongyao Hao, Xianguo Chen, and Chaozhao LiangFrom:BioMed Research International (Vol. 2021) Peer-Reviewed

  Sept. 27, 20214,891 words Report 1260LBackground and Objective. Selenoprotein P (SEPP1) is the major selenoprotein in plasma. Previous studies have demonstrated that SEPP1 expression was reduced in human prostate and colon tumors. Nowadays, studies...
• Select Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice

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  Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice

  Authors:Sergey V. Novoselov, Hwa-Young Kim, Deame Hua, Byung Cheon Lee, Clinton M. Astle, David E. Harrison, et al.From:Antioxidants & Redox Signaling (Vol. 12, Issue 7) Peer-Reviewed

  Apr. 1, 20106,037 words Report Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we...
• Select Effects of selenoprotein S on oxidative injury in human endothelial cells

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  Effects of selenoprotein S on oxidative injury in human endothelial cells

  Authors:Yin Zhao, Hua Li, Li-li Men, Rong-chong Huang, Hai-cheng Zhou, Qian Xing, et al.From:Journal of Translational Medicine (Vol. 11, Issue 1) Peer-Reviewed

  Nov. 14, 20134,588 words Report 1340LBackground Selenoprotein S (SelS) is an important endoplasmic reticulum and plasma membrane-located selenoprotein implicated in inflammatory responses and insulin resistance. However, the effects of SelS on...
• Select Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.

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  Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.

  Authors:Haruki Fujisawa, Manassawee Korwutthikulrangsri, Jiao Fu, Xiao-Hui Liao, and Alexandra M. DumitrescuFrom:Endocrinology (Vol. 161, Issue 5) Peer-Reviewed

  May 20207,529 words Report 1650LSelenocysteine insertion sequence-binding protein 2, SBP2 (SECISBP2), is required for selenoprotein synthesis. Partial SBP2 deficiency syndrome manifests characteristic thyroid function tests. The Sbp2 deficiency mouse...
• Select Research from National Cancer Institute (NCI) Yields New Study Findings on Cancer (Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I).

  12

  Research from National Cancer Institute (NCI) Yields New Study Findings on Cancer (Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I).

  From:Obesity, Fitness & Wellness Week

  Apr. 30, 2022550 words Article 1370L2022 APR 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on cancer are presented in a new report. According to news reporting from the National Cancer Institute (NCI)...
• Select Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M

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  Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M

  Authors:Yona Kim, Jun Seo Goo, Il Yong Kim, Ji Eun Kim, Moon Hwa Kwak, Jun Go, et al.From:International Journal of Molecular Medicine (Vol. 34, Issue 6) Peer-Reviewed

  Dec. 20146,891 words Report 1440LThe present study was conducted to investigate whether the high antioxidant activity induced by selenium (Sel) treatment and selenoprotein M (SelM) overexpression affected the protein profile of the brain cortex. To...
• Select New Findings in Lung Cancer Described from Tianjin University of Science and Technology (Selenious-beta-lactoglobulin induces the apoptosis of human lung cancer A549 cells via an intrinsic mitochondrial pathway)

  14

  New Findings in Lung Cancer Described from Tianjin University of Science and Technology (Selenious-beta-lactoglobulin induces the apoptosis of human lung cancer A549 cells via an intrinsic mitochondrial pathway)

  From:Obesity, Fitness & Wellness Week

  Dec. 29, 2018416 words Article 1410L2018 DEC 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Oncology - Lung Cancer have been published. According to news reporting originating from...
• Select Findings from Kanazawa University in the Area of Type 2 Diabetes Described (Lauric Acid Impairs Insulin-induced Akt Phosphorylation By Upregulatin Selenop Expression Via Hnf4 Alpha Induction).

  15

  Findings from Kanazawa University in the Area of Type 2 Diabetes Described (Lauric Acid Impairs Insulin-induced Akt Phosphorylation By Upregulatin Selenop Expression Via Hnf4 Alpha Induction).

  From:Obesity, Fitness & Wellness Week

  Sept. 3, 2022548 words Article 1370L2022 SEP 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes. According to news...
• Select Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

  16

  Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

  Authors:Marcus Conrad and Ulrich SchweizerFrom:Antioxidants & Redox Signaling (Vol. 12, Issue 7) Peer-Reviewed

  Apr. 1, 201011,948 words Report Selenium (Se), in the form of the 21st amino acid selenocysteine, is an integral part of selenoproteins and essential for mammals. While a large number of health claims for Se has been proposed in a diverse set of...
• Select Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells

  17

  Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells

  Authors:Aniruddha Sengupta, Bradley A. Carlson, Vyacheslav M. Labunskyy, Vadim N. Gladyshev, and Dolph L. HatfieldFrom:Biochemistry and Cell Biology (Vol. 87, Issue 6) Peer-Reviewed

  Dec. 20093,943 words Clinical report Mammalian selenoproteins have diverse functions, cellular locations, and evolutionary histories, but all use the amino acid selenocysteine (Sec), often present in the enzyme's active site. Only about half of mammalian...
• Select Selenium cysteine and epileptic seizures

  18

  Selenium cysteine and epileptic seizures

  Author:Ueli SchiblerFrom:Nature Reviews Molecular Cell Biology (Vol. 19, Issue 12) Peer-Reviewed

  Dec. 2018600 words Report 1370LUeli Schibler explains why the phenotype of a mutation in a codon of the '21st amino acid' selenium cysteine was unexpectedly specific. Author(s): Ueli Schibler 1 Author Affiliations: (1) Professor Emeritus,...
• Select Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection

  19

  Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection

  Authors:Moritz A. N. Pohl, Tiehui Wang, Thitiya Pohl, John Sweetman, Samuel A. M. Martin, and Christopher J. SecombesFrom:PLoS ONE (Vol. 13, Issue 12) Peer-Reviewed

  Dec. 20, 20189,484 words Report 1580LThe following research was conducted to elucidate the evolution and expression of salmonid selenoprotein P (SelP), a selenoprotein that is unique in having multiple selenocysteine (Sec) residues, following...
• Select Insights into the hierarchy of selenium incorporation

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  Insights into the hierarchy of selenium incorporation

  Author:Marla J BerryFrom:Nature Genetics (Vol. 37, Issue 11) Peer-Reviewed

  Nov. 20051,377 words Article 1560LAuthor(s): Marla J Berry [1] Selenium, a micronutrient with antioxidant properties, has garnered attention for potential roles in cancer prevention and delaying the aging process [1]. Low levels of this trace element...