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    Academic Journals

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• Implications from the SIV model in understanding HIV neutralization

  Authors:Anna Lauren and Eva Maria FenyoFrom:HIV Therapy (Vol. 2, Issue 1)

  Jan. 20087,249 words Article Author(s): Anna Laurén 1 , Eva Maria Fenyö [[dagger]] 2 Keywords: autologous neutralization; CD4-independence; coreceptor use; evolution to neutralization resistance; heterologous neutralization; HIV-1; HIV-2;...

• Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques

  Authors:Timothy W. Baba, Yong Seok Jeong, Dominique Penninck, Rod Bronson, Michael F. Greene, and Ruth M. RuprechtFrom:Science (Vol. 267, Issue 5205) Peer-Reviewed

  Mar. 24, 19953,949 words Article Adult macaques do not develop disease after infection with a nef deletion mutant of the simian immunodeficiency virus (SIV) and are protected against challenge with pathogenic virus. This finding led to the proposal to...

• Monkey study prompts high-level public health response

  Author:Jon CohenFrom:Science (Vol. 272, Issue 5263) Peer-Reviewed

  May 10, 19961,022 words Article A study indicating that monkeys treated with the hormone progesterone have a higher risk of SIV infection has caused urgent public health concern about AIDS risk. More than 2.5 million women in the US use implanted...

• Localized Populations of CD8.sup.low/- MHC Class I Tetramer.sup.+ SIV-Specific T Cells in Lymphoid Follicles and Genital Epithelium

  Authors:Jung Joo Hong, Matthew R. Reynolds, Teresa L. Mattila, Aaron Hage, David I. Watkins, Christopher J. Miller, et al.From:PLoS ONE (Vol. 4, Issue 1) Peer-Reviewed

  Jan. 5, 20096,552 words Article 1610LCD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected...

• Biologically-Directed Modeling Reflects Cytolytic Clearance of SIV-Infected Cells In Vivo in Macaques

  Authors:W. David Wick and Otto O. YangFrom:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 13, 20128,537 words Article 1710LThe disappointing outcomes of cellular immune-based vaccines against HIV-1 despite strong evidence for the protective role of CD8.sup.+ T lymphocytes (CTLs) has prompted revisiting the mechanisms of cellular immunity....

• Rapid Dissemination of SIV Follows Multisite Entry after Rectal Inoculation

  Authors:Patricia Ribeiro dos Santos, Magali Rancez, Jean-Luc Pretet, Alice Michel-Salzat, Valerie Messent, Anna Bogdanova, et al.From:PLoS ONE (Vol. 6, Issue 5) Peer-Reviewed

  May 9, 201110,257 words Article 1410LReceptive ano-rectal intercourse is a major cause of HIV infection in men having sex with men and in heterosexuals. Current knowledge of the mechanisms of entry and dissemination during HIV rectal transmission is scarce...

• Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection

  Authors:Andrew D. Walsh, Benjamin N. Bimber, Arpita Das, Shari M. Piaskowski, Eva G. Rakasz, Alexander T. Bean, et al.From:PLoS ONE (Vol. 8, Issue 5) Peer-Reviewed

  May 6, 20137,157 words Article 1530LCD8+ T Lymphocytes (CTL) can control AIDS virus replication. However, natural selection favoring viral variants that escape CTL recognition is a common feature of both simian immunodeficiency virus (SIV) infection of...

• Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque

  Authors:Zhao-Wan Yang, Yan-Hua Jiang, Chuang Ma, Guido Silvestri, Steven E. Bosinger, Bai-Lian Li, et al.From:PLoS ONE (Vol. 11, Issue 6) Peer-Reviewed

  June 9, 20169,818 words Report 1490LTo explore the differences between the extreme SIV infection phenotypes, nonprogression (BEN: benign) to AIDS in sooty mangabeys (SMs) and progression to AIDS (MAL: malignant) in rhesus macaques (RMs), we performed an...

• Enhancing SIV-specific immunity in vivo by PD-1 blockade

  Authors:Vijayakumar Velu, Kehmia Titanji, Baogong Zhu, Sajid Husain, Annette Pladevega, Lilin Lai, et al.From:Nature (Vol. 458, Issue 7235) Peer-Reviewed

  Mar. 12, 20094,930 words Clinical report 1460LChronic immunodeficiency virus infections are characterized by dysfunctional cellular and humoral antiviral immune responses (1-3). As such, immune modulatory therapies that enhance and/or restore the function of...

• Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

  Authors:Nichole R. Klatt, Lauren A. Canary, Xiaoyong Sun, Carol L. Vinton, Nicholas T. Funderburg, David R. Morcock, et al.From:Journal of Clinical Investigation (Vol. 123, Issue 2) Peer-Reviewed

  Feb. 20133,014 words Report 1450LHIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore,...

• The secretion of IL-22 from mucosal [NKp44.sup.+] NK cells is associated with microbial translocation and virus infection in SIV/SHIV-infected Chinese macaques

  Authors:Wei Wang, Fangxin Wu, Zhe Cong, Kejian Liu, Chuan Qin, and Qiang WeiFrom:Journal of Immunology Research (Vol. 2014) Peer-Reviewed

  Annual 20147,053 words Report 1500LMicrobial translocation (MT) causes systemic immune activation in chronic human immunodeficiency virus (HIV) infection. The role of a novel subtype of innate lymphoid cells, the NKp[44.sup.+] NK cells, in HIV/simian...

• Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS

  Authors:Jennifer H. Campbell, Tricia H. Burdo, Patrick Autissier, Jeffrey P. Bombardier, Susan V. Westmoreland, Caroline Soulas, et al.From:PLoS ONE (Vol. 6, Issue 4) Peer-Reviewed

  Apr. 6, 20117,161 words Article 1460LBackground Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline's functions are not well...

• Immune clearance of highly pathogenic SIV infection

  Authors:Scott G. Hansen, Michael Piatak Jr, Abigail B. Ventura, Colette M. Hughes, Roxanne M. Gilbride, Julia C. Ford, et al.From:Nature (Vol. 502, Issue 7469) Peer-Reviewed

  Oct. 20138,526 words Report 1920LCellular immune responses in rhesus macaques (Macaca mulatta) vaccinated with cytomegalovirus vectors expressing SIV proteins are able to stringently control highly pathogenic SIV infection, regardless of the route of...

• Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.

  Authors:Gema Mendez-Lagares, Ning Chin, W.L. William Chang, Jaewon Lee, Miriam Rosas- Umbert, Hung T. Kieu, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202110,406 words Report 1380LInterindividual immune variability is driven predominantly by environmental factors, including exposure to chronic infectious agents such as cytomegalovirus (CMV). We investigated the effects of rhesus CMV (RhCMV) on...

• Human SIV infections suspected

  Author:Joseph PalcaFrom:Science (Vol. 257, Issue 5070) Peer-Reviewed

  July 31, 1992523 words Article Can simian immunodeficiency virus (SIV), a relative of the human AIDS virus once thought to infect only monkeys, also infect humans? The disturbing answer may be yes, according to the Centers for Disease Control (CDC)...

• Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

  Authors:Muthiah D. Daniel, Frank Kirchhoff, Susan C. Czajak, Prabhat K. Sehgal, and Ronald C. DesrosiersFrom:Science (Vol. 258, Issue 5090) Peer-Reviewed

  Dec. 18, 19922,756 words Article Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the...

• Relationships between IL-17.sup.+ Subsets, Tregs and pDCs That Distinguish among SIV Infected Elite Controllers, Low, Medium and High Viral Load Rhesus Macaques

  Authors:Ladawan Khowawisetsut, Kovit Pattanapanyasat, Nattawat Onlamoon, Ann E. Mayne, Dawn M. Little, Francois Villinger, et al.From:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 19, 201311,810 words Article 1720LAuthor(s): Ladawan Khowawisetsut 1,2, Kovit Pattanapanyasat 2,3,*, Nattawat Onlamoon 2,3, Ann E. Mayne 1, Dawn M. Little 1, Francois Villinger 1,4, Aftab A. Ansari 1,* Introduction Dysregulation of the immune...

• Focused Examination of the Intestinal Epithelium Reveals Transcriptional Signatures Consistent with Disturbances in Enterocyte Maturation and Differentiation during the Course of SIV Infection

  Authors:Mahesh Mohan, Deepak Kaushal, Pyone P. Aye, Xavier Alvarez, Ronald S. Veazey, and Andrew A. LacknerFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 9, 201310,407 words Article 1700LThe Gastrointestinal (GI) tract plays a pivotal role in AIDS pathogenesis as it is the primary site for viral transmission, replication and CD4.sup.+ T cell destruction. Accordingly, GI disease (enteropathy) has become...

• Simian immunodeficiency virus-based lentivirus vector for retinal gene transfer: a preclinical safety study in adult rats

  Authors:Y Ikeda, Y Goto, Y Yonemitsu, M Miyazaki, T Sakamoto, T Ishibashi, et al.From:Gene Therapy (Vol. 10, Issue 14) Peer-Reviewed

  July 2, 20036,245 words Article 1710LAlthough lentivirus vectors hold promise for ocular gene therapy, they also have potential safety issues, particularly in the case of the current human immunodeficiency virus-based vectors. We recently developed a novel...

• Tissue-Specific B-Cell Dysfunction and Generalized Memory B-Cell Loss during Acute SIV Infection

  Authors:Sandrine Peruchon, Nada Chaoul, Chantal Burelout, Benoit Delache, Patricia Brochard, Pascale Laurent, et al.From:PLoS ONE (Vol. 4, Issue 6) Peer-Reviewed

  June 19, 200910,733 words Article 1610LBackground Primary HIV-infected patients display severe and irreversible damage to different blood B-cell subsets which is not restored by highly efficient anti-retroviral therapy (HAART). Because longitudinal...