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    Academic Journals

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• CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children

  Authors:Mathias Rask-Andersen, Gaetan Philippot, George Moschonis, George Dedoussis, Yannis Manios, Claude Marcus, et al.From:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20144,433 words Report 1430LFive novel loci recently found to be associated with body mass in two GWAS of East Asian populations were evaluated in two cohorts of Swedish and Greek children and adolescents. These loci are located within, or in the...

• SNP's and its correlation with hypertension: A comprehensive review

  Authors:Manohar Murugan, Karthikeyan Ramalingam, M. Nazzuredin, Hussain Rashed, and Ganesh PunamalaiFrom:Dentistry and Medical Research (Vol. 1, Issue 1) Peer-Reviewed

  January-June 20133,067 words Article 1760LByline: Manohar. Murugan, Karthikeyan. Ramalingam, M. Nazzuredin, Hussain. Rashed, Ganesh. Punamalai Hypertension is a growing global problem, which mostly affects the adults. It is a risk factor for death from...

• Genetic variation in Otos is associated with cisplatin-induced ototoxicity

  Authors:Timothy F Spracklen, Heather Whitehorn, Anna Alvera Vorster, Lebogang Ramma, Sameera Dalvie, and Rajkumar S RamesarFrom:Pharmacogenomics (Vol. 15, Issue 13) Peer-Reviewed

  Oct. 20146,242 words Report 1600LAuthor(s): Timothy F Spracklen aff1 , Heather Whitehorn aff1 , Anna Alvera Vorster aff1 , Lebogang Ramma aff2 , Sameera Dalvie aff3 , Rajkumar S Ramesar [*] aff1 Keywords: cisplatin; hearing loss; Otos ;...

• Lack of association between rs211037 of the GABRG2 gene and juvenile myoclonic epilepsy in Brazilian population

  Authors:Delma De Almeida, Fernando Gameleira, Tiago De Andrade, and Luciana MachadoFrom:Neurology India (Vol. 60, Issue 6) Peer-Reviewed

  November-December 20122,941 words Report 1580LByline: Livia. Gitai, Delma. de Almeida, Joao Paulo. Born, Fernando. Gameleira, Tiago. de Andrade, Luciana. Machado, Daniel. Gitai Background: Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epilepsy...

• Matrix metalloproteinase-2 gene polymorphism is not associated with increased glioblastoma multiforme susceptibility: An Indian institutional experience

  Authors:Raj Kumar, Nitin Malik, Arun Tungaria, and Priyanka KawalFrom:Neurology India (Vol. 59, Issue 2) Peer-Reviewed

  March-April 20113,147 words Clinical report 1490LByline: Raj. Kumar, Nitin. Malik, Arun. Tungaria, Priyanka. Kawal Background: Glioblastoma multiforme (GBM) is a highly malignant central nervous system tumor that is extremely refractory to therapy due to its rapid...

• Challenges and recommendations for conducting epidemiological studies in the field of epilepsy pharmacogenetics

  Authors:Sandeep Grover, Meenal Gupta, and Ritushree KukretiFrom:Indian Journal of Human Genetics (Vol. 17, Issue 4) Peer-Reviewed

  May 20114,807 words Report 1790LByline: Sandeep. Grover, Meenal. Gupta, Ritushree. Kukreti Epilepsy is one of the most prevalent neurological disorders, afflicting approximately 50 million Indians. Owing to affordability and easy availability, use...

• Accuracy of NAT2 SNP genotyping panels to infer acetylator phenotypes in African, Asian, Amerindian and admixed populations

  Authors:Guilherme Suarez-Kurtz, Daniela D Vargens, Vinicius A Sortica, and Mara H HutzFrom:Pharmacogenomics (Vol. 13, Issue 8) Peer-Reviewed

  June 20121,917 words Report 1650LAuthor(s): Guilherme Suarez-Kurtz [*] 3 , Daniela D Vargens 1 , Vinicius A Sortica 2 , Mara H Hutz 2 In a recent article in Pharmacogenomics , Hein and Doll assessed the accuracy of different genotyping panels to...

• Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I

  From:Molecular Diagnosis & Therapy (Vol. 14, Issue 4) Peer-Reviewed

  July-August 2010461 words Report 1320LThe calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant drugs used for the prevention of organ rejection following transplantation. Both agents are metabolic substrates for cytochrome...

• News & Views in ... Epigenomics

  From:Epigenomics (Vol. 2, Issue 2) Peer-Reviewed

  Apr. 2010398 words Report 1510LThis finding will have an impact on our understanding of the origins of individual phenotypic differences and will have implications for future genetic studies of complex disease. The February 2010 issue of the...

• A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

  Authors:Harald Staiger, Alena Stancakova, Jone Zilinskaite, Markku Vanttinen, Torben Hansen, Maria Adelaide Marini, et al.From:Diabetes (Vol. 57, Issue 2) Peer-Reviewed

  Feb. 20083,263 words Clinical report 1580LOBJECTIVE--In recent genome-wide association studies, two single nucleotide polymorphisms (SNPs) near the HHEX locus were shown to be more frequent in type 2 diabetic patients than in control subjects. Based on HHEX's...

• Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study

  Authors:Clara Kelliny, Ulf Ekelund, Lars Bo Andersen, Soren Brage, Ruth J.F. Loos, Nicholas J. Wareham, et al.From:Diabetes (Vol. 58, Issue 12) Peer-Reviewed

  Dec. 20095,265 words Report 1660LOBJECTIVE--The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children. RESEARCH DESIGN AND METHODS--Single...

• Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes

  Authors:Cristen J. Willer, Lori L. Bonnycastle, Karen N. Conneely, William L. Duren, Anne U. Jackson, Laura J. Scott, et al.From:Diabetes (Vol. 56, Issue 1) Peer-Reviewed

  Jan. 20077,809 words Article 1710LMore than 120 published reports have described associations between single nucleotide polymorphisms (SNPs) and type 2 diabetes. However, multiple studies of the same variant have often been discordant. From a literature...

• Visualizing gene determinants of disease in drug discovery

  Authors:Olivier Delrieu and Clive BowmanFrom:Pharmacogenomics (Vol. 7, Issue 3) Peer-Reviewed

  Apr. 20065,311 words Report 1530LAuthor(s): Olivier Delrieu, Clive Bowman [[dagger]] 1 Keywords: Bayes; case-control study; disease; drug discovery; filter; gene; individualization; multivariate method; population heterogeneity; single nucleotide...

• How many SNPs does a genome-wide haplotype map require?

  Authors:Richard Judson, Benjamin Salisbury, Julie Schneider, Andreas Windemuth, and J. Claiborne StephensFrom:Pharmacogenomics (Vol. 3, Issue 3) Peer-Reviewed

  May 1, 20028,686 words Article 1270LWe derive and compare several estimates of the number of SNPs that would be required to form the basis of a complete haplotype survey of the human genome. Our estimates make use of reports published by Stephens et al....

• Association of vWA and TPOX polymorphisms with venous thrombosis in Mexican Mestizos

  Authors:Marco Antonio Meraz-Rios, Abraham Majluf-Cruz, Carla Santana, Gino Noris, Rafael Camacho-Mejorado, Leonor C. Acosta-Saavedra, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20145,698 words Report 1420LObjective. Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality. Genetic factors play a critical role in its aetiology. Microsatellites are the...

• Genes encoding enzymes involved in ethanol metabolism

  Authors:Thomas D. Hurley and Howard J. EdenburgFrom:Alcohol Research: Current Reviews (Vol. 34, Issue 3) Peer-Reviewed

  Fall 20124,508 words Report 1560LThe effects of beverage alcohol (ethanol) on the body are determined largely by the rate at which it and its main breakdown product, acetaldehyde, are metabolized after consumption. The main metabolic pathway for...

• Selection Signature Analysis Implicates the PC1/PCSK1 Region for Chicken Abdominal Fat Content

  Authors:Hui Zhang, Xiaoxiang Hu, Zhipeng Wang, Yuandan Zhang, Shouzhi Wang, Ning Wang, et al.From:PLoS ONE (Vol. 7, Issue 7) Peer-Reviewed

  July 11, 20127,507 words Article 1530LAuthor(s): Hui Zhang 1 , 2 , Xiaoxiang Hu 3 , Zhipeng Wang 1 , 2 , Yuandan Zhang 4 , Shouzhi Wang 1 , 2 , Ning Wang 1 , 2 , Li Ma 5 , Li Leng 1 , 2 , Shengwen Wang 5 , Qigui Wang 1 , 2 , Yuxiang Wang 1 , 2 , Zhiquan...

• Limitations of the Human Reference Genome for Personalized Genomics

  Authors:Jeffrey A. Rosenfeld, Christopher E. Mason, and Todd M. SmithFrom:PLoS ONE (Vol. 7, Issue 7) Peer-Reviewed

  July 11, 20126,080 words Article 1460LAuthor(s): Jeffrey A. Rosenfeld 1 , 2 , Christopher E. Mason 3 , 4 , Todd M. Smith 5 , * Introduction A primary goal of the human genome project was to produce a high quality DNA sequence that could serve as a...

• Meta-Analysis of 125 Rheumatoid Arthritis-Related Single Nucleotide Polymorphisms Studied in the Past Two Decades

  Authors:Yongshuai Jiang, Ruijie Zhang, Jiajia Zheng, Panpan Liu, Guoping Tang, Hongchao Lv, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 10, 20124,078 words Article 1120LAuthor(s): Yongshuai Jiang 1 , Ruijie Zhang 1 , * , Jiajia Zheng 1 , Panpan Liu 1 , Guoping Tang 1 , Hongchao Lv 1 , Lanying Zhang 1 , Zhenwei Shang 1 , Yuanbo Zhan 2 , Wenhua Lv 1 , Miao Shi 1 , Ruimin Zhang 2 , *...

• The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size

  Authors:Anokhi Ali Khan, Alina Rodriguez, Sylvain Sebert, Marika Kaakinen, Stephane Cauchi, Philippe Froguel, et al.From:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 7, 20126,125 words Article 1560LAuthor(s): Anokhi Ali Khan 1 , Alina Rodriguez 1 , 2 , 3 , Sylvain Sebert 1 , 4 , Marika Kaakinen 4 , 5 , Stéphane Cauchi 6 , Philippe Froguel 6 , 7 , Anna-Liisa Hartikainen 8 , Anneli Pouta 8 , 9 , Marjo-Riitta...