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From:Pediatric Nephrology (Vol. 28, Issue 1) Peer-ReviewedGrowth retardation remains a clinical problem in children with chronic kidney disease (CKD) prior to and during end-stage renal disease. The growth of approximately 40% of children on dialysis is stunted. Even so,...
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From:International Journal of Pediatric Endocrinology (Vol. 2009) Peer-ReviewedAuthors: ArlanL Rosenbloom (corresponding author) [1] 1. What Is Idiopathic Short Stature? Short stature is often defined statistically as height less than -2 standard deviations (SD) of the age- and sex-matched...
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From:Nature (Vol. 537, Issue 7620) Peer-ReviewedAuthor(s): Hieab H. H. Adams [1, 2]; Sonja A. Swanson [1, 3]; Albert Hofman [1, 3]; M. Arfan Ikram (corresponding author) [1, 2, 4] ARISING FROM Z. Jaunmuktane et al . Nature 525, 247250 (2015);...
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From:Pharmacogenomics (Vol. 5, Issue 6) Peer-ReviewedDos Santos C, Essioux L, Teinturier C, Tauber M, Goffin V, Bougneres P: Nat. Genet. 36(7), 720-724 (2004). In two cohorts of short children treated with growth hormone, an isoform of the growth hormone receptor gene...
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From:Proceedings of the North Dakota Academy of Science (Vol. 67) Peer-ReviewedMethylation reactions are important for the establishment and maintenance of epigenetic methylation tags on DNA and histone molecules critical for the development and life-long function of an organism. Global DNA...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2016) Peer-ReviewedGrowth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age-related reductions. This has promoted many reports for studying the...
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From:Applied Physiology, Nutrition, and Metabolism (Vol. 39, Issue 7) Peer-ReviewedThis study aimed at evaluating a peak oxygen uptake test as a simple diagnostic tool to assess growth-hormone deficiency (GHD) in adults. Based on the findings of multiple growth hormone (GH) samplings after the...
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From:International Journal of Endocrinology (Vol. 2017) Peer-ReviewedBackground. Some, however not all, children with growth hormone deficiency (GHD) reveal a tendency towards metabolic disorders. Insulin-like growth factor I (IGF-I) is the main mediator of GH anabolic effects....
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From:PLoS ONE (Vol. 9, Issue 4) Peer-ReviewedShould growth hormone (GH) transgenic Atlantic salmon escape, there may be the potential for ecological and genetic impacts on wild populations. This study compared the developmental rate and respiratory metabolism of...
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From:Archives of Neuropsychiatry (Vol. 53, Issue 3) Peer-ReviewedIntroduction: Bipolar disorder is one of the most debilitating psychiatric disorders characterized by disruptive episodes of mania/hypomania and depression. Considering the complex role of biological and environmental...
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From:Nature (Vol. 525, Issue 7568) Peer-ReviewedPeople who died of the neurodegenerative condition Creutzfeldt-Jakob disease after treatment with cadaver-derived human growth hormone also developed some of the pathological traits of Alzheimer's disease. SEE LETTER P....
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From:eLife (Vol. 9) Peer-ReviewedThe sox2 expressing (sox2.sup.+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout...
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From:International Journal of Pediatric Endocrinology (Vol. 2015, Issue 1) Peer-ReviewedBackground A primary goal of recombinant human growth hormone therapy (GHT) in children is attaining normal adult height. In this study, children with growth hormone deficiency (GHD) (including isolated idiopathic...
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From:PeerJ (Vol. 9) Peer-ReviewedBackground The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may...
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From:PLoS ONE (Vol. 6, Issue 9) Peer-ReviewedHoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 has been shown...
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From:PLoS ONE (Vol. 8, Issue 7) Peer-ReviewedBackground Previous imaging studies on functional dyspepsia (FD) have focused on abnormal brain functions during special tasks, while few studies concentrated on the resting-state abnormalities of FD patients, which...
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From:PLoS ONE (Vol. 3, Issue 3) Peer-ReviewedPrader-Willi syndrome (PWS) is the leading genetic cause of obesity. After initial severe hypotonia, PWS children become hyperphagic and morbidly obese, if intake is not restricted. Short stature with abnormal growth...
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From:PLoS ONE (Vol. 5, Issue 5) Peer-ReviewedBackground Bisphenol A (BPA), used in the manufacture of plastics, is ubiquitously distributed in the aquatic environment. However, the effect of maternal transfer of these xenobiotics on embryonic development and...
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From:PLoS ONE (Vol. 7, Issue 11) Peer-ReviewedHere we demonstrate, both in vivo and in vitro, that growth hormone (GH) mediates precursor cell activation in the subventricular zone (SVZ) of the aged (12-month-old) brain following exercise, and that GH signaling...
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From:Thyroid Research (Vol. 5, Issue 1) Peer-ReviewedBackground Altered somatotrophic signaling is among the most important potential mechanisms of extended longevity. Ames dwarf (df/df) mice are homozygous for mutation at the Prop-1 gene, leading to a lack of growth...