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    Academic Journals

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• Selective depletion in HIV infection of T cells that bear specific T cell receptor V-beta sequences

  Authors:Luisa Imberti, Alessandra Sottini, Alessandra Bettinardi, Massimo Puoti, and Daniele PrimiFrom:Science (Vol. 254, Issue 5033) Peer-Reviewed

  Nov. 8, 19911,639 words Article MOST ANTIGENS ARE RECOGNIZED through their interaction with the variable V portions of the T cell receptor (TCR) [alpha] and [beta] chains (1). However, T cells recognize another category of ligands, the superantigens,...

• T cell tolerance

  Authors:Philippa Marrack, James McCormack, Jill Callahan, Leszek Ignatowicz, and John KapplerFrom:Chest (Vol. 103, Issue 2) Peer-Reviewed

  Feb. 19932,079 words Article The genes for the [alpha] and [beta] chains of the T cell antigen receptor are constructed, like those of immunoglobulin light and heavy chains, by gene rearrangement. During its development, each T cell has the choice...

• Cloning and expression of human membrane-bound and soluble engineered T cell receptors for immunotherapy

  Authors:Nehad M. Alajez, Saman Eghtesad, and Olivera J. FinnFrom:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20063,488 words Article 1650LWe report here the design and construction of several gene vectors for expression in mammalian cells of membrane-bound and soluble human T cell receptors (TR).We designed a vector (TR-ALPHA-IRES-TR-BETA pEF4) that...

• Nkg2d signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

  Authors:Frederick J. Kohlhapp, Andrew Zloza, Jason M. Schenkel, Gretchen E. Lyons, Andrew T. Lacek, Tamson V. Moore, et al.From:Nature Medicine (Vol. 18, Issue 3) Peer-Reviewed

  Mar. 20126,011 words Report 1530LCD4-unhelped CD8+ T cells are functionally defective T cells primed in the absence of CD4+ T cell help. Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8+ T cells, we investigated...

• Class II-Independent Generation of CD4 Memory T Cells from Effectors

  Authors:Susan L. Swain, Hui Hu, and Gail HustonFrom:Science (Vol. 286, Issue 5443) Peer-Reviewed

  Nov. 12, 19992,761 words Article The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in...

• Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

  Authors:Emily K. Griffiths, Connie Krawczyk, Young-Yun Kong, Monika Raab, Sharon J. Hyduk, Denis Bouchard, et al.From:Science (Vol. 293, Issue 5538) Peer-Reviewed

  Sept. 21, 20012,522 words Article The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit...

• NR4A transcription factors limit CAR T cell function in solid tumours

  Authors:Joyce Chen, Isaac F. Lopez-Moyado, Hyungseok Seo, Chan-Wang J. Lio, Laura J. Hempleman, Takashi Sekiya, et al.From:Nature (Vol. 567, Issue 7749) Peer-Reviewed

  Mar. 20199,910 words Technical report 1590LAuthor(s): Joyce Chen 1 2 3 4 , Isaac F. López-Moyado 1 4 5 , Hyungseok Seo 1 , Chan-Wang J. Lio 1 , Laura J. Hempleman 1 , Takashi Sekiya 6 , Akihiko Yoshimura 7 , James P. Scott-Browne 1 4 9 , Anjana Rao 1 3 4 8...

• CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction

  Authors:Hiran M. Thyagarajan, Jessica N. Lancaster, Sergio A. Lira, and Lauren I. R. EhrlichFrom:PLoS ONE (Vol. 13, Issue 7) Peer-Reviewed

  July 19, 20189,088 words Report 1540LFollowing positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes expressing T cell receptors (TCRs) with high affinity for...

• Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection

  Authors:Julia Drylewicz, Nienke Vrisekoop, Tendai Mugwagwa, Anne Bregje de Boer, Sigrid A. Otto, Mette D. Hazenberg, et al.From:PLoS ONE (Vol. 11, Issue 3) Peer-Reviewed

  Mar. 24, 20166,585 words Report 1750LNaive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have suggested that this is due to increased naive T-cell division. It...

• PolyCTLDesigner: a computational tool for constructing polyepitope T-cell antigens

  Authors:Denis V Antonets and Sergei I BazhanFrom:BMC Research Notes (Vol. 6, Issue 1) Peer-Reviewed

  Oct. 10, 20133,881 words Report 1570LBackground Construction of artificial polyepitope antigens is one of the most promising strategies for developing more efficient and safer vaccines evoking T-cell immune responses. Epitope rearrangements and...

• The role of self-peptides in direct T cell allorecognition.

  Authors:Hossam A. Abdelsamed and Fadi G. LakkisFrom:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-Reviewed

  Nov. 1, 20212,133 words Article 1460LDirect allorecognition, the ability of host T cells to recognize intact allogeneic MHC molecules on transplanted tissues, is often assumed to be less dependent on the peptide bound to the MHC molecule than are other...

• A gut punch fights cancer and infection

  Authors:Nathan E. Reticker-Flynn and Edgar G. EnglemanFrom:Nature (Vol. 565, Issue 7737) Peer-Reviewed

  Jan. 20191,788 words Article 1610LMicroorganisms in the human gut can affect immune-system cells. Gut bacterial strains have been discovered that boost immune cells that have cell-killing capacity and that can target cancer and protect against...

• Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides

  Authors:Mark D. Howell, Steven T. Winters, Tsaiwei Olee, Henry C. Powell, Dennis J. Carlo, and Steven W. BrostoffFrom:Science (Vol. 246, Issue 4930) Peer-Reviewed

  Nov. 3, 19891,949 words Article Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides ENCEPHALITOGENIC T CELLS [1-3] from mouse and rat models of EAE use common germline TCR genes [4-8], despite known differences...

• The innate immune system: a repository for future drugs?

  Authors:Suryaprakash Sambhara and Robert I LehrerFrom:Expert Review of Anti-infective Therapy (Vol. 5, Issue 1) Peer-Reviewed

  Feb. 20072,748 words Report Author(s): Suryaprakash Sambhara [[dagger]] 1 , Robert I Lehrer 2 For over 60 years, antibiotics have enabled millions of people to survive infections that would have been lethal in earlier eras. However, the...

• T-cell costimulation blockade in immunologic diseases: role of CD28 family members

  Authors:Bryan S Clay and Anne I SperlingFrom:Expert Review of Clinical Immunology (Vol. 3, Issue 3) Peer-Reviewed

  May 20078,871 words Report Author(s): Bryan S Clay [[dagger]] 1 , Anne I Sperling 2 Keywords: autoimmunity; CD28; costimulation; CTLA-4; ICOS; PD-1; T cell Since many immunologic diseases are T-cell mediated, the promise of treatments...

• Immunology: How a T cell sees sugar

  Author:D. Branch MoodyFrom:Nature (Vol. 448, Issue 7149) Peer-Reviewed

  July 5, 20071,568 words Report 1460LAuthor(s): D. Branch Moody [1] Most cellular receptors coevolve with their target ligands through repeated interactions over millennia. The immune system has no such luxury. When new infectious agents such as HIV or...

• DYNAMICS OF T-CELL RECEPTOR: CD3 COMPLEX CELL SURFACE EXPRESSION AND DOWN MODULATION

  Authors:HAO NGUYEN and DAVID O'DROBINAKFrom:Journal of the Tennessee Academy of SciencePeer-Reviewed

  January-April 2000185 words Brief article DYNAMICS OF T-CELL RECEPTOR: CD3 COMPLEX CELL SURFACE EXPRESSION AND DOWN MODULATION. Haiyan Liu [*], Dario A. Vignal, Michele Rhodes, and David Wiest, The University of Tennessee, Memphis, Memphis, Tennessee (HL), St....

• Dissecting the immunological synapse: researchers want to understand the control center of the activation process. (Research)

  Author:Josh P. RobertsFrom:The Scientist (Vol. 17, Issue 9) Peer-Reviewed

  May 5, 20031,555 words Article "We can do things that haven't been done before, I think, ever in cell biology," exclaims Mark Davis of Stanford University. His 3-D, fluorescence video-microscopy system allows him to count the number of antigen...

• An immune boost to the war on cancer

  Author:Nigel WilliamsFrom:Science (Vol. 272, Issue 5258) Peer-Reviewed

  Apr. 5, 19962,486 words Article Advancement in the understanding of the immune system at the molecular level has led to innovative cancer treatments. Scientists are studying how cancer-attacking immune cells work. Studies indicate that T cells are...

• Activation-induced ubiquitination of the T cell antigen receptor

  Authors:Cristina Cenciarelli, Damon Hou, Kou-Ching Hsu, Barbara L. Rellahan, David L. Wiest, Harry T. Smith, et al.From:Science (Vol. 257, Issue 5071) Peer-Reviewed

  Aug. 7, 19921,799 words Article The [zeta] subunit of the T cell antigen receptor (TCR) exists primarily as a disulfide-linked homodimer. This receptor subunit is important in TCR-mediated signal transduction and is a substrate for a TCR-activated...