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    Academic Journals

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• RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39[degrees]C.

  Authors:Li-Min Guo, Zhen Wang, Shi-Ping Li, Mi Wang, Wei-Tao Yan, Feng-Xia Liu, et al.From:Neural Regeneration Research (Vol. 15, Issue 5) Peer-Reviewed

  May 20207,097 words Article 1390LByline: Li-Min. Guo, Zhen. Wang, Shi-Ping. Li, Mi. Wang, Wei-Tao. Yan, Feng-Xia. Liu, Chu-Dong. Wang, Xu-Dong. Zhang, Dan. Chen, Jie. Yan, Kun. Xiong Methamphetamine is one of the most prevalent drugs abused in the...

• Yokukansan, a Traditional Japanese Medicine, Enhances the Glutamate Transporter GLT-1 Function in Cultured Rat Cortical Astrocytes.

  Authors:Toshiyuki Ueki, Zenji Kawakami, Hitomi Kanno, Yuji Omiya, Kazushige Mizoguchi, and Masahiro YamamotoFrom:Evidence - Based Complementary and Alternative Medicine (Vol. 2018) Peer-Reviewed

  Annual 20186,261 words Article 1410LAstrocytes carry two glutamate transporters--GLAST and GLT-1--the latter of which is responsible for >90% of glutamate uptake activity in the brain; however, under culture conditions, the GLT-1 expression in astrocytes...

• Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.

  Authors:Petra Simic, Wondong Kim, Wen Zhou, Kerry A. Pierce, Wenhan Chang, David B. Sykes, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 3) Peer-Reviewed

  Mar. 202010,670 words Article 1460LFibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin [D.sub.3] [1,25[(OH).sub.2]D] production....

• Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.

  Authors:Leiming Wang, Mafei Xu, Chung-Yang Kao, Sophia Y. Tsai, and Ming-Jer TsaiFrom:Journal of Clinical Investigation (Vol. 130, Issue 4) Peer-Reviewed

  Apr. 20207,412 words Article 1390LRecent findings have shown that inhibitors targeting bromodomain and extraterminal domain (BET) proteins, such as the small molecule JQ1, are potent growth inhibitors of many cancers and hold promise for cancer therapy....

• Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP.

  Authors:Tõnis Org, Kati Hensen, Rita Kreevan, Elina Mark, Olav Sarv, Reidar Andreson, et al.From:PLoS ONE (Vol. 14, Issue 11) Peer-Reviewed

  Nov. 25, 201912,508 words Article 1580LChromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq) has revolutionized our understanding of chromatin-related biological processes. The method, however, requires thousands of cells and has...

• Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.

  Authors:Adrian Pickar-Oliver, Joshua B. Black, Mae M. Lewis, Kevin J. Mutchnick, Tyler S. Klann, Kylie A. Gilcrest, et al.From:Nature Biotechnology (Vol. 37, Issue 12) Peer-Reviewed

  Dec. 20199,300 words Article 1490LClass 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely used to target DNA sequences in eukaryotic genomes. However, class 1 CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature,...

• Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1[alpha]/[beta]-mediated adaptive stress response pathway in skeletal muscle cells.

  Authors:Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef, and Valerio OrlandoFrom:Epigenetics & Chromatin (Vol. 12, Issue 1) Peer-Reviewed

  Dec. 19, 20197,085 words Article 1430LBackground While the role of Polycomb group protein-mediated "cell memory" is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells....

• Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells.

  Authors:Atsuo Kurata, Yukako Tachibana, Tadakatsu Takahashi, and Naoshi HoribaFrom:PLoS ONE (Vol. 15, Issue 4) Peer-Reviewed

  Apr. 23, 20206,312 words Article 1330LChronic kidney diseases affect more than 800 million people globally and remain a high unmet need. Various therapeutic targets are currently under evaluation in pre-clinical and clinical studies. Because the growth...

• CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.

  Authors:Chenyu Ding, Zanyi Wu, Honghai You, Hongliang Ge, Shufa Zheng, Yuanxiang Lin, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  Dec. 30, 20195,404 words Article 1550LBackground Circular RNA nuclear factor I X (circNFIX) has been reported to play an important role in glioma progression. However, the mechanism by which circNFIX participates in glioma progression remains poorly...

• Profiling tear proteomes of patients with unilateral relapsed Behcet's disease-associated uveitis using data-independent acquisition proteomics.

  Authors:Anyi Liang, Weiwei Qin, Meifen Zhang, Fei Gao, Chan Zhao, and Youhe GaoFrom:PeerJ (Vol. 8) Peer-Reviewed

  June 19, 20205,435 words Article 1360LPurpose To explore whether unilateral relapse of Bechet's disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers...

• Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.

  Authors:Shan Xu, Rachel W. S. Chan, Tianqi Li, Ernest H. Y. Ng, and William S. B. YeungFrom:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-Reviewed

  June 17, 20207,953 words Article 1410LBackground The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the...

• Improvement of Flavonoids in Lemon Seeds on Oxidative Damage of Human Embryonic Kidney 293T Cells Induced by [H.sub.2][O.sub.2].

  Authors:Dingyi Yang, Yong Jiang, Yuqing Wang, Qianqian Lei, Xin Zhao, Ruokun Yi, et al.From:Oxidative Medicine and Cellular LongevityPeer-Reviewed

  May 31, 20205,359 words Article 1530LIn this study, flavonoids in lemon seeds (FLS) were used to assess its improvement on the oxidative damage of human embryonic kidney 293T cells (HEK 293T cells) induced by [H.sub.2][O.sub.2]. In vitro experiments showed...

• MicroRNA-424-5p inhibits the proliferation, migration, and invasion of nasopharyngeal carcinoma cells by decreasing AKT3 expression.

  Authors:Chong Zhao, Feng Zhao, Huiying Chen, Yuehua Liu, and Jiping SuFrom:Brazilian Journal of Medical and Biological Research (Vol. 53, Issue 7) Peer-Reviewed

  July 20205,149 words Article 1420LThis study examined the expression and potential mechanism of microRNA (miRNA)-424-5p in nasopharyngeal carcinoma (NPC). NPC tissues were collected from 40 patients who were enrolled in the study, and skin samples were...

• Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.

  Authors:Rocio Bengoechea, Andrew R. Findlay, Ankan K. Bhadra, Hao Shao, Kevin C. Stein, Sara K. Pittman, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 8) Peer-Reviewed

  Aug. 20209,685 words Article 1340LDominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology....

• Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.

  Authors:Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 10) Peer-Reviewed

  Oct. 20207,977 words Article 1430LUsing the Nephrotic Syndrome Study Network Consortium data set and other publicly available transcriptomic data sets, we identified retinoic acid receptor responder protein 1 (RARRES1) as a gene whose expression...

• The Activation of Phosphatidylserine/CD36/TGF-[beta]1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats.

  Authors:Lei Huang, Hailiang Tang, Prativa Sherchan, Cameron Lenahan, Warren Holing, Jiping Tang, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2020) Peer-Reviewed

  Aug. 31, 20206,695 words Article 1390LNeuroinflammation plays an important pathological role in experimental surgical brain injury (SBI). Apoptotic associated with phosphatidylserine (PS) externalization promotes anti-inflammatory mediator TGF-[beta]1...

• The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment.

  Authors:Qian Zhang, Hongqiao Shi, Jiaan Zhang, Chenxue Jiang, and Chunxiang ZhouFrom:PeerJ (Vol. 9) Peer-Reviewed

  May 25, 20216,421 words Report 1190LBackground Paeonol is a potent therapy for psoriasis. This study aimed to screen out paeonol-targeted genes in psoriasis and validate the potential of using paeonol for the management of psoriasis. Methods...

• PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans.

  Authors:Heesun Kim, Yue-He Ding, Shan Lu, Mei-Qing Zuo, Wendy Tan, Darryl Conte, et al.From:eLife (Vol. 10) Peer-Reviewed

  May 18, 202120,475 words Article 1480LGermlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or...

• The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth.

  Authors:Baisakhi Mondal, Hongjian Jin, Satish Kallappagoudar, Yurii Sedkov, Tanner Martinez, Monica F Sentmanat, et al.From:eLife (Vol. 9) Peer-Reviewed

  Apr. 16, 202019,218 words Article 1500LThe mitotic deacetylase complex (MiDAC) is a recently identified histone deacetylase (HDAC) complex. While other HDAC complexes have been implicated in neurogenesis, the physiological role of MiDAC remains unknown. Here,...

• Exosomes mediate sensory hair cell protection in the inner ear.

  Authors:Andrew M. Breglio, Lindsey A. May, Melanie Barzik, Nora C. Welsh, Shimon P. Francis, Tucker Q. Costain, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 5) Peer-Reviewed

  May 202011,753 words Article 1350LHair cells, the mechanosensory receptors of the inner ear, are responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely...