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    Academic Journals

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• Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.

  Authors:Petra Simic, Wondong Kim, Wen Zhou, Kerry A. Pierce, Wenhan Chang, David B. Sykes, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 3) Peer-Reviewed

  Mar. 202010,670 words Article 1460LFibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin [D.sub.3] [1,25[(OH).sub.2]D] production....

• The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth.

  Authors:Baisakhi Mondal, Hongjian Jin, Satish Kallappagoudar, Yurii Sedkov, Tanner Martinez, Monica F Sentmanat, et al.From:eLife (Vol. 9) Peer-Reviewed

  Apr. 16, 202019,218 words Article 1500LThe mitotic deacetylase complex (MiDAC) is a recently identified histone deacetylase (HDAC) complex. While other HDAC complexes have been implicated in neurogenesis, the physiological role of MiDAC remains unknown. Here,...

• Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.

  Authors:Adrian Pickar-Oliver, Joshua B. Black, Mae M. Lewis, Kevin J. Mutchnick, Tyler S. Klann, Kylie A. Gilcrest, et al.From:Nature Biotechnology (Vol. 37, Issue 12) Peer-Reviewed

  Dec. 20199,300 words Article 1490LClass 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely used to target DNA sequences in eukaryotic genomes. However, class 1 CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature,...

• Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1[alpha]/[beta]-mediated adaptive stress response pathway in skeletal muscle cells.

  Authors:Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef, and Valerio OrlandoFrom:Epigenetics & Chromatin (Vol. 12, Issue 1) Peer-Reviewed

  Dec. 19, 20197,085 words Article 1430LBackground While the role of Polycomb group protein-mediated "cell memory" is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells....

• A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.

  Authors:Tara L Mastro, Anthony Preza, Shinjini Basu, Sumantra Chattarji, Sally M Till, Peter C Kind, et al.From:eLife (Vol. 9) Peer-Reviewed

  Jan. 15, 202010,945 words Article 1410LSynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state...

• Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3[sigma] and YAP1.

  Authors:Yajuan Guo, Catherine J Redmond, Krystynne A Leacock, Margarita V Brovkina, Suyun Ji, Vinod Jaskula-Ranga, et al.From:eLife (Vol. 9) Peer-Reviewed

  May 5, 202015,156 words Article 1460LThe intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and...

• Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.

  Authors:Shan Xu, Rachel W. S. Chan, Tianqi Li, Ernest H. Y. Ng, and William S. B. YeungFrom:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-Reviewed

  June 17, 20207,953 words Article 1410LBackground The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the...

• Profiling tear proteomes of patients with unilateral relapsed Behcet's disease-associated uveitis using data-independent acquisition proteomics.

  Authors:Anyi Liang, Weiwei Qin, Meifen Zhang, Fei Gao, Chan Zhao, and Youhe GaoFrom:PeerJ (Vol. 8) Peer-Reviewed

  June 19, 20205,435 words Article 1360LPurpose To explore whether unilateral relapse of Bechet's disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers...

• Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.

  Authors:Rocio Bengoechea, Andrew R. Findlay, Ankan K. Bhadra, Hao Shao, Kevin C. Stein, Sara K. Pittman, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 8) Peer-Reviewed

  Aug. 20209,685 words Article 1340LDominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology....

• Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.

  Authors:Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 10) Peer-Reviewed

  Oct. 20207,977 words Article 1430LUsing the Nephrotic Syndrome Study Network Consortium data set and other publicly available transcriptomic data sets, we identified retinoic acid receptor responder protein 1 (RARRES1) as a gene whose expression...

• PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans.

  Authors:Heesun Kim, Yue-He Ding, Shan Lu, Mei-Qing Zuo, Wendy Tan, Darryl Conte, et al.From:eLife (Vol. 10) Peer-Reviewed

  May 18, 202120,475 words Article 1480LGermlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or...

• Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation.

  Authors:Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, et al.From:Stem Cell Research & Therapy (Vol. 12, Issue 1) Peer-Reviewed

  May 29, 20218,272 words Article 1510LBackground The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the...

• Instability in NAD.sup.+ metabolism leads to impaired cardiac mitochondrial function and communication.

  Authors:Knut H Lauritzen, Maria Belland Olsen, Mohammed Shakil Ahmed, Kuan Yang, Johanne Egge Rinholm, Linda H Bergersen, et al.From:eLife (Vol. 10) Peer-Reviewed

  Aug. 3, 202113,405 words Article 1500LPoly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD.sup.+) as energy source. Prolonged PARP activity can drain cellular NAD.sup.+ reserves, leading...

• Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting.

  Authors:Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-Reviewed

  Aug. 7, 202110,605 words Article 1500LBackground The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths...

• PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis.

  Authors:So-Young Lee, Hyun-Ju An, Jin Man Kim, Min-Ji Sung, Do Kyung Kim, Hyung Kyung Kim, et al.From:Stem Cell Research & Therapy (Vol. 12, Issue 1) Peer-Reviewed

  Nov. 25, 20216,982 words Article 1420LBackground PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is...

• Kidney organoids recapitulate human basement membrane assembly in health and disease.

  Authors:Mychel RPT Morais, Pinyuan Tian, Craig Lawless, Syed Murtuza-Baker, Louise Hopkinson, Steven Woods, et al.From:eLife (Vol. 11) Peer-Reviewed

  Jan. 25, 202218,814 words Article 1560LBasement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include collagen IV and laminins, which are affected by human genetic variants leading to a...

• Is there an app for that? Highlights of apps for separation science

  From:LC-GC North America (Vol. 33, Issue 10) Peer-Reviewed

  Oct. 2015102 words Brief article 1200LAPP NAME: HPLC Troubleshooting Guide OFFERED BY: Thermo Scientific PLATFORMS: Android, iPhone (optimized for iPhone 5), iPad, IPod Touch WHAT IT DOES: This app diagnoses various potential issues with HPLC...

• Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

  Authors:John Repass, Elizabeth Iorns, Alexandria Denis, Stephen R Williams, Nicole Perfito, and Timothy M ErringtonFrom:eLife (Vol. 7) Peer-Reviewed

  Mar. 13, 201810,072 words Report 1560LAs part of the Reproducibility Project: Cancer Biology (https://osf.io/e81xl/wiki/home/), we published a Registered Report (Repass et al., 2016), that described how we intended to replicate an experiment from the paper...

• The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

  Authors:Akira Karasawa, Kevin Michalski, Polina Mikhelzon, and Toshimitsu KawateFrom:eLife (Vol. 6) Peer-Reviewed

  Sept. 18, 201715,641 words Article 1380LThe P2X7 receptor mediates extracellular ATP signaling implicated in the development of devastating diseases such as chronic pain and cancer. Activation of the P2X7 receptor leads to opening of the characteristic...

• A universal vector concept for a direct genotyping of transgenic organisms and a systematic creation of homozygous lines

  Authors:Frederic Strobl, Anita Anderl, and Ernst HK StelzerFrom:eLife (Vol. 7) Peer-Reviewed

  Mar. 15, 201822,435 words Article 1520LDiploid transgenic organisms are either hemi- or homozygous. Genetic assays are, therefore, required to identify the genotype. Our AGameOfClones vector concept uses two clearly distinguishable transformation markers...