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Academic Journals
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From:Journal of Clinical Investigation (Vol. 130, Issue 3) Peer-ReviewedFibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin [D.sub.3] [1,25[(OH).sub.2]D] production....
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From:eLife (Vol. 9) Peer-ReviewedThe mitotic deacetylase complex (MiDAC) is a recently identified histone deacetylase (HDAC) complex. While other HDAC complexes have been implicated in neurogenesis, the physiological role of MiDAC remains unknown. Here,...
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From:Nature Biotechnology (Vol. 37, Issue 12) Peer-ReviewedClass 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely used to target DNA sequences in eukaryotic genomes. However, class 1 CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature,...
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From:Epigenetics & Chromatin (Vol. 12, Issue 1) Peer-ReviewedBackground While the role of Polycomb group protein-mediated "cell memory" is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells....
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From:eLife (Vol. 9) Peer-ReviewedSynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state...
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From:eLife (Vol. 9) Peer-ReviewedThe intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and...
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From:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-ReviewedBackground The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the...
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From:PeerJ (Vol. 8) Peer-ReviewedPurpose To explore whether unilateral relapse of Bechet's disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers...
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From:Journal of Clinical Investigation (Vol. 130, Issue 8) Peer-ReviewedDominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology....
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From:Journal of Clinical Investigation (Vol. 130, Issue 10) Peer-ReviewedUsing the Nephrotic Syndrome Study Network Consortium data set and other publicly available transcriptomic data sets, we identified retinoic acid receptor responder protein 1 (RARRES1) as a gene whose expression...
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From:eLife (Vol. 10) Peer-ReviewedGermlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or...
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From:Stem Cell Research & Therapy (Vol. 12, Issue 1) Peer-ReviewedBackground The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the...
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From:eLife (Vol. 10) Peer-ReviewedPoly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD.sup.+) as energy source. Prolonged PARP activity can drain cellular NAD.sup.+ reserves, leading...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedBackground The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths...
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From:Stem Cell Research & Therapy (Vol. 12, Issue 1) Peer-ReviewedBackground PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is...
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From:eLife (Vol. 11) Peer-ReviewedBasement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include collagen IV and laminins, which are affected by human genetic variants leading to a...
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From:LC-GC North America (Vol. 33, Issue 10) Peer-ReviewedAPP NAME: HPLC Troubleshooting Guide OFFERED BY: Thermo Scientific PLATFORMS: Android, iPhone (optimized for iPhone 5), iPad, IPod Touch WHAT IT DOES: This app diagnoses various potential issues with HPLC...
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From:eLife (Vol. 7) Peer-ReviewedAs part of the Reproducibility Project: Cancer Biology (https://osf.io/e81xl/wiki/home/), we published a Registered Report (Repass et al., 2016), that described how we intended to replicate an experiment from the paper...
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From:eLife (Vol. 6) Peer-ReviewedThe P2X7 receptor mediates extracellular ATP signaling implicated in the development of devastating diseases such as chronic pain and cancer. Activation of the P2X7 receptor leads to opening of the characteristic...
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From:eLife (Vol. 7) Peer-ReviewedDiploid transgenic organisms are either hemi- or homozygous. Genetic assays are, therefore, required to identify the genotype. Our AGameOfClones vector concept uses two clearly distinguishable transformation markers...