Search Results

• • 35 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Identification and Characterization of the Regions Involved in the Nuclear Translocation of the Heterodimeric Leishmanial DNA Topoisomerase IB

  From:PLoS ONE (Vol. 8, Issue 9) Peer-Reviewed

  Sept. 2, 20136,536 words Report 1400LIntroduction Visceral leishmaniasis is a growing scourge in an increasingly globalized world, where biological and environmental barriers fluctuate constantly. The causative agent,

• Parallel G-quadruplexes formed by guanine-rich microsatellite repeats inhibit human topoisomerase I

  Authors:A.M. Ogloblina, V.A. Bannikova, A.N. Khristich, T.S. Oretskaya, M.G. Yakubovskaya, and N.G. DolinnayaFrom:Biochemistry (Moscow) (Vol. 80, Issue 8) Peer-Reviewed

  Aug. 20157,697 words Report 1450LUsing UV and CD spectroscopy, we studied the thermodynamic stability and folding topology of G-quadruplexes ([G.sub.4]), formed by G-rich fragments in human microsatellites that differ in the number of guanosines within...

• High resolution melting analysis for rapid mutation screening in gyrase and topoisomerase IV genes in quinolone-resistant Salmonella enterica

  Authors:Soo Tein Ngoi and Kwai Lin ThongFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20144,106 words Report 1380LThe increased Salmonella resistance to quinolones and fluoroquinolones is a public health concern in the Southeast Asian region. The objective of this study is to develop a high resolution melt curve (HRM) assay to...

• Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

  Authors:Kenta Yamamoto, Jiguang Wang, Lisa Sprinzen, Jun Xu, Christopher J Haddock, Chen Li, et al.From:eLife (Vol. 5) Peer-Reviewed

  June 15, 201618,804 words Report 1550LMissense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for cancer therapy are largely unknown. Here we report that 72%...

• Type IIA topoisomerase inhibition by a new class of antibacterial agents

  Authors:Benjamin D. Bax, Pan F. Chan, Drake S. Eggleston, Andrew Fosberry, Daniel R. Gentry, Fabrice Gorrec, et al.From:Nature (Vol. 466, Issue 7309) Peer-Reviewed

  Aug. 19, 20109,416 words Report 1530LDespite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address increasing multidrug resistance. Type IIA topoisomerases...

• Camptothecins and their novel anticancer properties evaluated by using pass method

  Authors:N. Behrangi, M. Hashemi, Y. Doustar, and Borna H.From:Advances in Environmental BiologyPeer-Reviewed

  Aug. 20112,070 words Report 1390LChemotherapy is one of the approaches applied for cancer treatment. Most of the drugs used today in chemotherapy have natural origins and were first discovered in plants, fruits and microorganisms. Camptothecins are...

• Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase II[alpha]

  Authors:Jingjing Chen, Zhouyi Zheng, Yi Chen, Jiaqi Li, Shanhu Qian, Yifen Shi, et al.From:PLoS ONE (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 8, 20165,709 words Report 1580LDysfunction of histone acetylation inhibits topoisomerase II[alpha] (Topo II[alpha]), which is implicated in benzene-induced hematotoxicity in patients with chronic benzene exposure. Whether histone deacetylase (HDAC)...

• Analysis of interactions between anthracyclines and topoisomerase II

  Authors:Nicole Frank, R.D. Olson, G.M. Walsh, Todd Talley, and Barry J. CusackFrom:Journal of the Idaho Academy of Science (Vol. 49, Issue 1) Peer-Reviewed

  June 2013225 words Author abstract, Bri... 1230LAnthracyclines, including doxorubicin are potent anticancer drugs but can cause severe chronic cardiotoxicity. To date there is no widely accepted mechanism for cardiotoxicity. Recent publications, however, have shown...

• Topoisomerase activity is linked to altered nucleosome positioning and transcriptional regulation in the fission yeast fbp1 gene

  Authors:Ryuta Asada, Satoshi Senmatsu, Ben Montpetit, and Kouji HirotaFrom:PLoS ONE (Vol. 15, Issue 11) Peer-Reviewed

  Nov. 12, 20208,414 words Report 1530LChromatin structure, including nucleosome positioning, has a fundamental role in transcriptional regulation through influencing protein-DNA interactions. DNA topology is known to influence chromatin structure, and in...

• Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

  Authors:Jessica Marinello, Stefania Bertoncini, Iris Aloisi, Agnese Cristini, Guidantonio Malagoli Tagliazucchi, Mattia Forcato, et al.From:PLoS ONE (Vol. 11, Issue 1) Peer-Reviewed

  Jan. 19, 20168,738 words Report 1490LTopoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at...

• Identification of novel bacterial DNA gyrase inhibitors: An in silico study

  Authors:Hamzeh Rahimi, Ali Najafi, Habib Eslami, Babak Negahdari, and Mehrdad MoghaddamFrom:Research in Pharmaceutical Sciences (Vol. 11, Issue 3) Peer-Reviewed

  May-June 20163,115 words Report 1480LByline: Hamzeh. Rahimi, Ali. Najafi, Habib. Eslami, Babak. Negahdari, Mehrdad. Moghaddam Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly...

• Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

  Authors:Angela M. Mabb, Jeremy M. Simon, Ian F. King, Hyeong-Min Lee, Lin-Kun An, Benjamin D. Philpot, et al.From:PLoS ONE (Vol. 11, Issue 5) Peer-Reviewed

  May 27, 20167,959 words Report 1360LTopoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed....

• Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

  Authors:Linlin Chang, Xiaowen Liu, Dandan Wang, Jian Ma, Tianyi Zhou, Ying Chen, et al.From:PLoS ONE (Vol. 10, Issue 12) Peer-Reviewed

  Dec. 9, 20156,708 words Report 1520LIn spite of the tremendous efforts dedicated to developing hypoxia-activated prodrugs, no agents yet have been approved for clinical therapy. In the present study, the hypoxic selective anti-cancer activity as well as...

• Functional expression of a DNA-topoisomerase IB from Cryptosporidium parvum

  Authors:Cesar Ordonez, Javier Alfonso, Rafael Balana-Fouce, and David OrdonezFrom:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20094,367 words Report Cryptosporidium parvum, one of the most important causative organisms of human diarrheas during childhood, contains a monomeric DNA-topoisomerase IB (CpTopIB) in chromosome 7. Heterologous expression of CpTopIB gene in...

• The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs

  Authors:William H. Gmeiner, Freddie Salsbury, Jr., Chris M. Olsen, and Luis A. MarkyFrom:Journal of Nucleic AcidsPeer-Reviewed

  Annual 20114,482 words Report 1580LTopoisomerase 1 (Top1) enzymes regulate DNA superhelicity by forming covalent cleavage complexes that undergo controlled rotation. Substitution of nucleoside analogs at the +1 position of the DNA duplex relative to the...

• Topoisomerases facilitate transcription of long genes linked to autism

  Authors:Ian F. King, Chandri N. Yandava, Angela M. Mabb, Jack S. Hsiao, Hsien-Sung Huang, Brandon L. Pearson, et al.From:Nature (Vol. 501, Issue 7465) Peer-Reviewed

  Sept. 5, 20135,478 words Report 1490LTopoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is...

• The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

  Authors:Mathias Munschauer, Celina T. Nguyen, Klara Sirokman, Christina R. Hartigan, Larson Hogstrom, Jesse M. Engreitz, et al.From:Nature (Vol. 561, Issue 7721) Peer-Reviewed

  Sept. 201813,824 words Report 1520LThe human genome contains thousands of long non-coding RNAs.sup.1, but specific biological functions and biochemical mechanisms have been discovered for only about a dozen.sup.2-7. A specific long non-coding...

• DNA topoisomerase II[beta] stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

  Authors:Merve Zaim and Sevim IsikFrom:Stem Cell Research & Therapy (Vol. 9, Issue 1) Peer-Reviewed

  Apr. 25, 20187,324 words Report 1470LBackground DNA topoisomerase II[beta] (topo II[beta]) is known to regulate neural differentiation by inducing the neuronal genes responsible for critical neural differentiation events such as neurite outgrowth and...

• Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer

  Authors:Yang Bai, Liang-Dong Li, Jun Li, and Xin LuFrom:Journal of Ovarian Research (Vol. 9, Issue 1) Peer-Reviewed

  June 18, 20166,001 words Report 1590LBackgroud As magicians of the DNA world, topoisomerases resolve all of the topological problems in relation to DNA during a variety of genetic processes. While the prognostic value of topoisomerase isoenzymes in...

• Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers

  Authors:Jinsheng Yu, Ryan Miller, Wanghai Zhang, Mala Sharma, Vicky Holtschlag, Mark A Watson, et al.From:Pharmacogenomics (Vol. 9, Issue 10) Peer-Reviewed

  Oct. 20083,363 words Clinical report 1570LAuthor(s): Jinsheng Yu 1 , Ryan Miller 1 2 , Wanghai Zhang 1 , Mala Sharma 1 , Vicky Holtschlag 1 , Mark A Watson 1 , Howard L McLeod [[dagger]] 2 Keywords : colorectal cancer; DNA copy-number; formalin-fixed...