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Academic Journals
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From:Epigenomics (Vol. 7, Issue 2) Peer-ReviewedAuthor(s): Duygu Ucar aff1 , Dashzeveg Bayarsaihan aff2 Keywords: enhancers; epigenetic regulation; H3K4me3; histone methylation Genome-wide histone modification profiles contain precious information hidden in...
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From:Nature Biotechnology (Vol. 33, Issue 5) Peer-ReviewedSpatial localization is a key determinant of cellular fate and behavior, but methods for spatially resolved, transcriptome-wide gene expression profiling across complex tissues are lacking. RNA staining methods assay...
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From:PLoS ONE (Vol. 9, Issue 12) Peer-ReviewedAuthor(s): The PLOS ONE Staff There is an error in Supporting Information Table S3. The headings in columns G and H are interchanged. Please view the corrected table below. Supporting Information Table S3...
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From:Future Virology (Vol. 7, Issue 7)Author(s): Dongsheng Li 1 , Vincent Cutillas 1 2 , Ting Wei [*] 3 Keywords * evasion tactic; histone H3 protein; hPAF1C Summary of methods & results Marazzi et al. found that NS1 from influenza virus...
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From:HIV Therapy (Vol. 4, Issue 1)Author(s): Tamara Bar-Magen 1 , Richard D Sloan 1 , Mark A Wainberg [[dagger]] 1 Restriction factors & replication A major theme was cellular factors that are responsible for regulating and restricting viral...
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From:Journal of Clinical Pathology (Vol. 54, Issue 7) Peer-ReviewedAbstract Aims--To investigate whether the three different AP-2 isoforms are expressed differently in colorectal adenomas and carcinomas. Methods--The study comprised 43 randomly selected patients diagnosed and...
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From:The Scientist (Vol. 15, Issue 7) Peer-ReviewedResearchers show how signals block death gene transcription factor Cell life depends on stringent repression of apoptosis, or programmed cell death. Repressing transcription of cell death genes is one way of...
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From:Science (Vol. 251, Issue 4995) Peer-ReviewedTHE MYOD GENE IS CAPABLE OF ACTIVATING PREVIOUSLY silent muscle-specific genes when introduced into a large variety of differentiated cell types with a viral long terminal repeat (LTR) used to promote constitutive...
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From:Science (Vol. 238, Issue 4832) Peer-ReviewedHuman Proto-Oncogene c-jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1 AGROWING NUMBER OF VIRAL AND CELLULAR GENES HAVE been identified as potential cancer...
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From:Science (Vol. 258, Issue 5086) Peer-ReviewedTo examine the basis for the evolutionary selection for codirectionality of replication and transcription in Escherichia coli, electron microscopy was used to visualize replication from an inducible ColE1 replication...
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From:Science (Vol. 257, Issue 5075) Peer-ReviewedThe transcriptional antiterminator protein BglG inhibits transcription termination of the bgl operon in Escherichia coli when it is in the nonphosphorylated state. The BglG protein is now shown to exist in two...
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From:Science (Vol. 256, Issue 5057) Peer-ReviewedA eukaryotic chromosomal origin of replication was identified in the yeast Saccharomyces cerevisiae. By several criteria, including map position, deletion analysis, and a synthetic form of saturation mutagenesis, the...
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From:Science (Vol. 256, Issue 5055) Peer-ReviewedTranscription factor NF-kB comprises two proteins, p50 and p65, that have sequence similarity to the v-rel oncogene. In primary hematopoietic cell populations an alternatively spliced form of NF-kB p65 mRNA was observed...
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From:Science (Vol. 255, Issue 5049) Peer-ReviewedSodium salicylate, an anti-inflammatory agent, was examined for its effects on the heat shock response in cultured human cells. Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was...
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From:Science (Vol. 253, Issue 5023) Peer-ReviewedSEVERE PROTEIN-INDUCED BENDING of DUPLEX DNA HAS been demonstrated by a variety of biochemical and biophysical techniques [1-10], including a low-resolution crystal structure of the nucleosome core particle [10]....
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From:Science (Vol. 259, Issue 5101) Peer-ReviewedPU.1 recruits the binding of a second B cell--restricted nuclear factor, NF-EM5, to a DNA site in the immunoglobulin [Kappa] 3' enhancer. DNA binding by NF-EM5 requires a protein-protein interaction with PU.1 and...
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From:Science (Vol. 261, Issue 5128) Peer-ReviewedIn budding yeast genes that encode G1 cyclins and proteins involved in DNA synthesis are transcriptionally activated in late G1. A transcription factor, called SBF, is composed of Swi4 and Swi6 proteins and activates...
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From:Science (Vol. 243, Issue 4891) Peer-ReviewedFunction of a Bacterial Activator Protein That Binds to Transcriptional Enhancers TRANSCRIPTIONAL ENHANCER SEQUENCES FOR EUKARYOTIC genes are binding sites for regulatory proteins. Enhancers lie at a distance from...
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From:Science (Vol. 244, Issue 4902) Peer-ReviewedOxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction THE FORMATION OF SPECIFIC NUcleic acid-protein complexes has been shown to play a key role in DNA transcription, pre-mRNA...
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From:Science (Vol. 247, Issue 4943) Peer-ReviewedA Potent GAL4 Derivative Activates Transcription at a Distance in Vitro GAL4 IS A TRANSCRIPTIONAL ACTIvator found in the yeast Saccharomyces cerevisiae [1]. The 881-amino acid protein binds as dimers to 17-bp dyad...