Search Results

• • 9,850 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Toward postnatal reversal of ocular congenital malformations

  Authors:Jose-Alain Sahel and Katia MarazovaFrom:Journal of Clinical Investigation (Vol. 124, Issue 1) Peer-Reviewed

  Jan. 20143,226 words Report 1390LAniridia is a panocular disorder that severely affects vision in early life. Most cases are caused by dominantly inherited mutations or deletions of the PAX6 gene, which encodes a transcription factor that is essential...

• Cell-specific gene promoters are marked by broader spans of H3K4me3 and are associated with robust gene expression patterns

  Authors:Duygu Ucar and Dashzeveg BayarsaihanFrom:Epigenomics (Vol. 7, Issue 2) Peer-Reviewed

  Apr. 20151,794 words Report 1860LAuthor(s): Duygu Ucar aff1 , Dashzeveg Bayarsaihan aff2 Keywords: enhancers; epigenetic regulation; H3K4me3; histone methylation Genome-wide histone modification profiles contain precious information hidden in...

• Spatial reconstruction of single-cell gene expression data

  Authors:Rahul Satija, Jeffrey A. Farrell, David Gennert, Alexander F. Schier, and Aviv RegevFrom:Nature Biotechnology (Vol. 33, Issue 5) Peer-Reviewed

  May 201513,951 words Report 1550LSpatial localization is a key determinant of cellular fate and behavior, but methods for spatially resolved, transcriptome-wide gene expression profiling across complex tissues are lacking. RNA staining methods assay...

• Correction: A Complete Set of Nascent Transcription Rates for Yeast Genes

  From:PLoS ONE (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 5, 2014199 words Brief article, Corre... 1290LAuthor(s): The PLOS ONE Staff There is an error in Supporting Information Table S3. The headings in columns G and H are interchanged. Please view the corrected table below. Supporting Information Table S3...

• Myxopyronin: a punch in the jaws of bacterial RNA polymerase

  Authors:Audrey Tupin, Maxime Gualtieri, Konstantin Brodolin, and Jean-Paul LeonettiFrom:Future Microbiology (Vol. 4, Issue 2)

  Mar. 20092,554 words Report Author(s): Audrey Tupin 1 , Maxime Gualtieri 2 , Konstantin Brodolin 3 , Jean-Paul Leonetti [[dagger]] 4 The growing challenge of antimicrobial resistance and the scarcity of novel antibiotics with new mechanisms of...

• Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1

  Authors:Emilie Pic, Jean-Philippe Gagne, and Guy G PoirierFrom:Expert Review of Proteomics (Vol. 8, Issue 6) Peer-Reviewed

  Dec. 201113,199 words Article 1520LAuthor(s): Emilie Pic 1 , Jean-Philippe Gagné 1 , Guy G Poirier [**] 2 Keywords : mass spectrometry; poly(ADP-ribose); poly(ADP-ribose) polymerase-1; post-translational modification; proteomics Several...

• Epigenetic regulation by nuclear receptors

  Authors:Christopher D Green and Jing-Dong J HanFrom:Epigenomics (Vol. 3, Issue 1) Peer-Reviewed

  Feb. 20119,930 words Report 1480LAuthor(s): Christopher D Green 1 2 , Jing-Dong J Han [[dagger]] 3 KEYWORDS : acetyltransferase; coactivator; corepressor; deacetylase; demethylase; epigenetics; genome wide; histone; methyltransferase; nuclear...

• Survival Factors and Apoptosis

  Author:TOM HOLLONFrom:The Scientist (Vol. 15, Issue 7) Peer-Reviewed

  Apr. 2, 2001736 words Brief article Researchers show how signals block death gene transcription factor Cell life depends on stringent repression of apoptosis, or programmed cell death. Repressing transcription of cell death genes is one way of...

• Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas; comparison of immunohistochemistry and in situ hybridisation

  Authors:K M Ropponen, J K Kellokoski, R T Pirinen, K I Moisia, M J Eskelinen, E M Alhava, et al.From:Journal of Clinical Pathology (Vol. 54, Issue 7) Peer-Reviewed

  July 20013,665 words Article Abstract Aims--To investigate whether the three different AP-2 isoforms are expressed differently in colorectal adenomas and carcinomas. Methods--The study comprised 43 randomly selected patients diagnosed and...

• Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP

  Authors:Jon D. Shuman, Charles R. Vinson, and Steven L. McKnightFrom:Science (Vol. 249, Issue 4970) Peer-Reviewed

  Aug. 17, 19903,226 words Article Evidence of Changes in Protease Sensitivity and Subunit Exchange Rate on DNA Binding by C/EBP THE TRANSCRIPTION FACTOR C/EBP regulates gene expression in a variety of tissues, including liver, adipose, lung, and...

• A potent GAL4 derivative activates transcription at a distance in vitro

  Authors:Michael Carey, Janet Leatherwood, and Mark PtashneFrom:Science (Vol. 247, Issue 4943) Peer-Reviewed

  Feb. 9, 19901,474 words Article A Potent GAL4 Derivative Activates Transcription at a Distance in Vitro GAL4 IS A TRANSCRIPTIONAL ACTIvator found in the yeast Saccharomyces cerevisiae [1]. The 881-amino acid protein binds as dimers to 17-bp dyad...

• Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1

  Authors:Dirk Bohmann, Timothy J. Bos, Arie Admon, Tetsuji Nishimura, Peter K. Vogt, and Robert TjianFrom:Science (Vol. 238, Issue 4832) Peer-Reviewed

  Dec. 4, 19876,650 words Article Human Proto-Oncogene c-jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1 AGROWING NUMBER OF VIRAL AND CELLULAR GENES HAVE been identified as potential cancer...

• Activation of adenovirus promoters by the adenovirus E1A protein in cell-free extracts

  Authors:Rudolph Spangler, Mark Bruner, Barbara Dalie, and Marian L. HarterFrom:Science (Vol. 237) Peer-Reviewed

  Aug. 28, 19873,643 words Article Activation of Adenovirus Promoters by the Adenovirus E1A Protein in Cell-Free Extracts THE ADENOVIRUS (Ad) E1A PROTEIN of 289 amino acids has the ability to either activate or repress RNA transcription from promoters...

• Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees

  Authors:Steve C. Schultz, George C. Shields, and Thomas A. SteitzFrom:Science (Vol. 253, Issue 5023) Peer-Reviewed

  Aug. 30, 19915,970 words Article SEVERE PROTEIN-INDUCED BENDING of DUPLEX DNA HAS been demonstrated by a variety of biochemical and biophysical techniques [1-10], including a low-resolution crystal structure of the nucleosome core particle [10]....

• The myoD gene family: nodal point during specification of the muscle cell lineage

  Authors:Harold Weintraub, Robert Davis, Stephen Tapscott, Matthew Thayer, Michael Krause, Robert Benezra, et al.From:Science (Vol. 251, Issue 4995) Peer-Reviewed

  Feb. 15, 19917,088 words Article THE MYOD GENE IS CAPABLE OF ACTIVATING PREVIOUSLY silent muscle-specific genes when introduced into a large variety of differentiated cell types with a viral long terminal repeat (LTR) used to promote constitutive...

• Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction

  Authors:Matthias W. Hentze, Tracey A. Rouault, Joe B. Harford, and Richard D. KlausnerFrom:Science (Vol. 244, Issue 4902) Peer-Reviewed

  Apr. 21, 19891,836 words Article Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction THE FORMATION OF SPECIFIC NUcleic acid-protein complexes has been shown to play a key role in DNA transcription, pre-mRNA...

• Similarity between the transcriptional silencer binding proteins ABF1 and RAP1

  Authors:John F.X. Diffley and Bruce StillmanFrom:Science (Vol. 246, Issue 4933) Peer-Reviewed

  Nov. 24, 19893,069 words Article Similarity Between the Transcriptional Silencer Binding Proteins ABFI and RAPI A CRITICAL FEATURE IN THE LIFE CYCLE of the the years Saccharomyces cerevisiae is that two loci, HML and HMR, which contain mating type...

• Function of a bacterial activator protein that binds to transcriptional enhancers

  Authors:David L. Popham, Daniel Szeto, John Keener, and Sydney KustuFrom:Science (Vol. 243, Issue 4891) Peer-Reviewed

  Feb. 3, 19893,429 words Article Function of a Bacterial Activator Protein That Binds to Transcriptional Enhancers TRANSCRIPTIONAL ENHANCER SEQUENCES FOR EUKARYOTIC genes are binding sites for regulatory proteins. Enhancers lie at a distance from...

• Consequences of replication fork movement through transcription units in vivo

  Author:Sarah FrenchFrom:Science (Vol. 258, Issue 5086) Peer-Reviewed

  Nov. 20, 19922,875 words Article To examine the basis for the evolutionary selection for codirectionality of replication and transcription in Escherichia coli, electron microscopy was used to visualize replication from an inducible ColE1 replication...

• Modulation of the dimerization of a transcriptional antiterminator protein by phosphorylation

  Authors:Orna Amster-Choder and Andrew WrightFrom:Science (Vol. 257, Issue 5075) Peer-Reviewed

  Sept. 4, 19922,141 words Article The transcriptional antiterminator protein BglG inhibits transcription termination of the bgl operon in Escherichia coli when it is in the nonphosphorylated state. The BglG protein is now shown to exist in two...