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Academic Journals
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From:PLoS ONE (Vol. 13, Issue 7) Peer-ReviewedGlucosamine (GlcN) is a naturally occurring derivative of glucose and an over-the-counter food additive. However, the mechanism underlying GlcN action on cells is unknown. In this study, we investigated the effect of...
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From:Saudi Journal of Kidney Diseases and Transplantation (Vol. 24, Issue 3) Peer-ReviewedByline: Weiguo. Sui, Hua. Lin, Yong. Dai, Jiejing. Chen, He. Huang Transcription factors (TFs) play a central role in regulating gene expression and in providing an interconnecting regulatory between related pathway...
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From:Pediatric Health (Vol. 4, Issue 1) Peer-ReviewedResearchers have employed chromosomal microarray mapping to characterize three patients with Jacobsen syndrome (11q-), a congenital heart condition, and have identified an important role for the ETS-1 transcription...
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From:BMC Research Notes (Vol. 2) Peer-ReviewedAuthors: Xuyu Zu (equal contributor) [1]; Lingling Yu (equal contributor) [1,3]; Qinsheng Sun [1,3]; Feng Liu [1]; Jue Wang [1]; Zhenhua Xie [1]; Ying Wang [1,3]; Wei Xu (corresponding author) [3]; Yuyang Jiang...
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From:Future Cardiology (Vol. 6, Issue 3) Peer-ReviewedAuthor(s): Antonella Cecchetto 1 , Alessandra Rampazzo 1 , Annalisa Angelini 1 , Lucia Dal Bianco 1 , Massimo Padalino 1 , Giovanni Stellin 1 , Luciano Daliento [[dagger]â ] 2 Keywords *⪠cardiac development;...
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From:PLoS ONE (Vol. 8, Issue 6) Peer-ReviewedAuthor(s): Lili Zhang 1,3, Zhenjun Li 2, Jingfu Li 3,*, Aoxue Wang 1,3,4,* Introduction During the long evolutionary history, plants have developed various strategies to cope with environmental stresses such as...
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From:PLoS ONE (Vol. 8, Issue 10) Peer-ReviewedIntroduction Forkhead transcription factors regulate diverse biological processes including embryogenesis, cellular differentiation, cell cycle control, and immune function [1,2]. One family member, forkhead box L2 (...
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From:PLoS ONE (Vol. 8, Issue 1) Peer-ReviewedAuthor(s): Aline Chevallier 1 , 5 , Antoine Mialot 2 , 5 , Jean-Maurice Petit 5 , Pedro Fernandez-Salguero 4 , Robert Barouki 1 , 3 , 5 , Xavier Coumoul 1 , 5 , * , Mathieu Beraneck 2 , 5 , * Introduction The Aryl...
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From:Nature Medicine (Vol. 22, Issue 6) Peer-ReviewedAuthor(s): Takuro Saito [1, 2]; Hiroyoshi Nishikawa (corresponding author) [1]; Hisashi Wada [2, 3]; Yuji Nagano [4]; Daisuke Sugiyama [1]; Koji Atarashi [4]; Yuka Maeda [1]; Masahide Hamaguchi [1]; Naganari Ohkura [1];...
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From:Proceedings of the North Dakota Academy of Science (Vol. 70) Peer-ReviewedThe SNAI1 gene encodes for a transcriptional factor (repressor) important in embryonic development and implicated in epithelial-to-mesenchymal transition (EMT), which occurs during cancer metastasis. Using a screen for...
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From:Journal of Clinical Investigation (Vol. 127, Issue 4) Peer-ReviewedA hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these...
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From:Nature (Vol. 531, Issue 7595) Peer-ReviewedThe energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) affects 3% of all hospitalized patients...
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From:Journal of Clinical Investigation (Vol. 125, Issue 11) Peer-ReviewedPolarized activation of adipose tissue macrophages (ATMs) is crucial for maintaining adipose tissue function and mediating obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory...
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From:Nature (Vol. 534, Issue 7605) Peer-ReviewedLiver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in...
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From:Gene Therapy (Vol. 21, Issue 11) Peer-ReviewedRetroviral vectors are versatile gene transfer vehicles widely used in basic research and gene therapy. Mutation of retroviral integrase converts these vectors into transient, integration-deficient gene delivery...
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From:Environmental Health Perspectives (Vol. 122, Issue 11) Peer-ReviewedEpidemiological studies suggest that prenatal and early-life exposures to certain chemicals can influence immune system function later in life. (1) However, the mechanisms by which these changes may occur remain...
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From:Neural Regeneration Research (Vol. 12, Issue 12) Peer-ReviewedByline: Wen-wei. Luo, Zhao. Han, Dong-dong. Ren, Xin-wei. Wang, Fang-lu. Chi, Juan-mei. Yang Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1...
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From:Journal of Clinical Investigation (Vol. 128, Issue 3) Peer-ReviewedClaudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we...
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From:European Journal of Clinical Nutrition (Vol. 68, Issue 3) Peer-ReviewedOBJECTIVES: We assessed the effect of cholecalciferol and calcium supplementation on mRNA expression of cathelicidin (LL-37), Th1 and Th2 cytokines and their transcription factors in the peripheral blood mononuclear...
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From:Journal of Clinical Investigation (Vol. 128, Issue 7) Peer-ReviewedDrug resistance remains the key problem in cancer treatment. It is now accepted that each myeloma patient harbors multiple subclones and subclone dominance may change over time. The coexistence of multiple subclones...