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Academic Journals
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From:PLoS ONE (Vol. 13, Issue 7) Peer-ReviewedGlucosamine (GlcN) is a naturally occurring derivative of glucose and an over-the-counter food additive. However, the mechanism underlying GlcN action on cells is unknown. In this study, we investigated the effect of...
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From:Saudi Journal of Kidney Diseases and Transplantation (Vol. 24, Issue 3) Peer-ReviewedByline: Weiguo. Sui, Hua. Lin, Yong. Dai, Jiejing. Chen, He. Huang Transcription factors (TFs) play a central role in regulating gene expression and in providing an interconnecting regulatory between related pathway...
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From:Pediatric Health (Vol. 4, Issue 1) Peer-ReviewedResearchers have employed chromosomal microarray mapping to characterize three patients with Jacobsen syndrome (11q-), a congenital heart condition, and have identified an important role for the ETS-1 transcription...
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From:Future Oncology (Vol. 5, Issue 1) Peer-ReviewedAuthor(s): Mireille Khacho 1 , Stephen Lee [[dagger]] 2 Keywords: Keywords 5,6-dichlorobenzimidazole (DRB); actinomycin D; E3 ubiquitin ligase; O 2 - and pH-dependent HIF regulation; pH-dependent nucleolar...
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From:Future Cardiology (Vol. 6, Issue 3) Peer-ReviewedAuthor(s): Antonella Cecchetto 1 , Alessandra Rampazzo 1 , Annalisa Angelini 1 , Lucia Dal Bianco 1 , Massimo Padalino 1 , Giovanni Stellin 1 , Luciano Daliento [[dagger]â ] 2 Keywords *⪠cardiac development;...
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From:PLoS ONE (Vol. 8, Issue 10) Peer-ReviewedIntroduction Forkhead transcription factors regulate diverse biological processes including embryogenesis, cellular differentiation, cell cycle control, and immune function [1,2]. One family member, forkhead box L2 (...
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From:PLoS ONE (Vol. 8, Issue 1) Peer-ReviewedAuthor(s): Aline Chevallier 1 , 5 , Antoine Mialot 2 , 5 , Jean-Maurice Petit 5 , Pedro Fernandez-Salguero 4 , Robert Barouki 1 , 3 , 5 , Xavier Coumoul 1 , 5 , * , Mathieu Beraneck 2 , 5 , * Introduction The Aryl...
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From:Nature Medicine (Vol. 22, Issue 6) Peer-ReviewedAuthor(s): Takuro Saito [1, 2]; Hiroyoshi Nishikawa (corresponding author) [1]; Hisashi Wada [2, 3]; Yuji Nagano [4]; Daisuke Sugiyama [1]; Koji Atarashi [4]; Yuka Maeda [1]; Masahide Hamaguchi [1]; Naganari Ohkura [1];...
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From:Proceedings of the North Dakota Academy of Science (Vol. 70) Peer-ReviewedThe SNAI1 gene encodes for a transcriptional factor (repressor) important in embryonic development and implicated in epithelial-to-mesenchymal transition (EMT), which occurs during cancer metastasis. Using a screen for...
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From:Journal of Clinical Investigation (Vol. 127, Issue 4) Peer-ReviewedA hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these...
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From:Journal of Clinical Investigation (Vol. 125, Issue 11) Peer-ReviewedPolarized activation of adipose tissue macrophages (ATMs) is crucial for maintaining adipose tissue function and mediating obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory...
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From:Nature (Vol. 534, Issue 7605) Peer-ReviewedLiver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in...
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From:Environmental Health Perspectives (Vol. 122, Issue 11) Peer-ReviewedEpidemiological studies suggest that prenatal and early-life exposures to certain chemicals can influence immune system function later in life. (1) However, the mechanisms by which these changes may occur remain...
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From:Journal of Clinical Investigation (Vol. 128, Issue 3) Peer-ReviewedClaudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we...
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From:Nature Medicine (Vol. 15, Issue 3) Peer-ReviewedOsteoclasts are acid-secreting polykaryons that have high energy demands and contain abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast differentiation is unknown. We found that the...
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From:Journal of Clinical Investigation (Vol. 128, Issue 7) Peer-ReviewedDrug resistance remains the key problem in cancer treatment. It is now accepted that each myeloma patient harbors multiple subclones and subclone dominance may change over time. The coexistence of multiple subclones...
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From:Network Biology (Vol. 4, Issue 3) Peer-ReviewedIn this work we study the preferential use of carbon sources in the bacterium Escherichia coli. To that end we engineered transcriptional fusions of the reporter gene gfpmut2, downstream of transcription-factor...
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From:Journal of Clinical Investigation (Vol. 128, Issue 8) Peer-ReviewedSkeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2017) Peer-ReviewedThe Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2017) Peer-ReviewedHigh oxygen levels during in vitro culture (IVC) can induce oxidative stress through accumulation of reactive oxygen species (ROS), negatively affecting embryo development. This study evaluated the effect of different...