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From:Gut (Vol. 52, Issue 11) Peer-ReviewedGut 2003;52:1567-1571 Background: IgA serum autoantibodies against tissue transglutaminase (tTG) have an established diagnostic value in coeliac disease, and high efficacy tests are widely available for their...
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From:Science (Vol. 243, Issue 4899) Peer-ReviewedFactor XIIIa--Expressing Dermal Dendrocytes in AIDS-Associated Cutaneous Kaposi's Sarcomas Kaposi's sarcoma (KS) is an angioproliferative neoplasm that develops as multifocal lesions, often involving the skin,...
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From:Pathology Research InternationalPeer-ReviewedTissue transglutaminase (tTG) is a ubiquitous multifunctional protein. It has roles in various cellular processes. tTG is a major target of autoantibodies in celiac disease, and its expression by immunohistochemistry in...
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From:PLoS ONE (Vol. 12, Issue 2) Peer-ReviewedBackground Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the metabolism of glutathione. Studies suggested that GGT played an important role in the tumor development, progression, invasion and...
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From:PLoS ONE (Vol. 17, Issue 1) Peer-ReviewedRenal clinical chemistry only detects kidney dysfunction after considerable damage has occurred and is imperfect in predicting long term outcomes. Consequently, more sensitive markers of early damage and better...
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From:Diabetes (Vol. 49, Issue 5) Peer-ReviewedTissue transglutaminase C (tTG) has been identified as an autoantigen target of antiendomysium antibodies (EMA), the serological marker of coeliac disease (CD). We detected tTGA-IgA by immunoenzymatic method, IgA...
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From:Science (Vol. 246, Issue 4934) Peer-ReviewedStructural Basis for Misaminoacylation by Mutant E. coli Glutaminyl-tRNA Synthetase Enzymes THE ACCURACY OF PROTEIN BIOSYNTHESIS in living cells depends critically on the acylation of transfer RNA (tRNA) molecules...
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From:PLoS ONE (Vol. 13, Issue 6) Peer-ReviewedRadioresistance is one of the main determinants of treatment outcome in oral squamous cell carcinoma (OSCC), but its prediction is difficult. Several authors aimed to establish radioresistant OSCC cell lines to identify...
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From:Neural Regeneration Research (Vol. 16, Issue 8) Peer-ReviewedByline: Jie. Zhang, Hilary. Jasutkar, M. Mouradian Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of a-synuclein (a-Syn) aggregates in Lewy bodies (LBs) and...
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From:Diabetes Care (Vol. 32, Issue 4) Peer-ReviewedOBJECTIVE--To estimate and compare associations of alanine aminotransferase (ALT) and [gamma]-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS--ALT and GGT were studied as determinants of...
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From:Lung (Vol. 194, Issue 5) Peer-ReviewedIntroduction Hypoxia has been implicated in the pathogenesis of many inflammatory and fibrotic lung diseases. The effect of hypoxia on epithelial junction protein expression is yet to be fully elucidated but evidence...
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From:Nature Medicine (Vol. 25, Issue 4) Peer-ReviewedAuthor(s): Meike E. W. Logtenberg 1 , J. H. Marco Jansen 2 , Matthijs Raaben 3 , Mireille Toebes 1 , Katka Franke 4 , Arianne M. Brandsma 2 , Hanke L. Matlung 4 , Astrid Fauster 3 , Raquel Gomez-Eerland 5 , Noor A. M....
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From:Science (Vol. 226) Peer-ReviewedTransglutaminase-Mediated Modifications of the Rat Sperm Surface in Vitro The mammalian male gamete acquires its basic differentiated phenotype in the tests; however, numerous subsequent adjustments in its molecular...
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From:PLoS ONE (Vol. 13, Issue 10) Peer-ReviewedMulti-functional transglutaminase 2 (TG2), which possesses protein cross-linking and GTP hydrolysis activities, is involved in various cellular processes, including apoptosis, angiogenesis, wound healing, and neuronal...
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From:Journal of Clinical Investigation (Vol. 125, Issue 7) Peer-ReviewedGlutaminase (GLS), which converts glutamine to glutamate, plays a key role In cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect...
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From:Autoimmune DiseasesPeer-ReviewedObjectives. We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease...
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From:Pediatrics (Vol. 118, Issue 6) Peer-ReviewedOBJECTIVES. Our goal was to evaluate the possible correspondence between antitissue transglutaminase of immunoglobulin A class levels and stage of mucosal damage in patients affected by celiac disease. In addition, we...
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From:Future Neurology (Vol. 4, Issue 4) Peer-ReviewedAuthor(s): Thomas M Jeitner [[dagger]] 1 , Nancy A Muma 2 , Kevin P Battaile 3 , Arthur JL Cooper 4 Keywords: Keywords Alzheimer's disease; calcium; Huntington's disease; neurodegeneration; Parkinson's disease;...
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From:Canadian Journal of Gastroenterology and HepatologyPeer-ReviewedOlmesartan, an angiotensin II receptor antagonist used to treat hypertension, is associated with few adverse effects. Here, a case of severe sprue-like enteropathy and acute kidney injury is described in a 68-year-old...
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From:Indian Journal of Dermatology, Venereology, and Leprology (Vol. 74, Issue 5) Peer-ReviewedByline: M. Namazi Sir, Amyloidosis is a generic term that signifies the abnormal extracellular tissue deposition of one of a family of biochemically unrelated proteins that share certain characteristic staining...