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• L-tryptophan is back

  Author:Alan R. GabyFrom:Original Internist (Vol. 17, Issue 1) Peer-Reviewed

  Mar. 2010815 words Article 1430LUnited States regulatory agencies have recently reversed a 20-year ban on the over-the-counter sale of the essential amino acid L-tryptophan, and will once again allow it to be sold as a dietary supplement. The United...

• The Antioxidant Role of Xanthurenic Acid in the Aedes aegypti Midgut during Digestion of a Blood Meal

  Authors:Vitor L. A. Lima, Felipe Dias, Rodrigo D. Nunes, Luiza O. Pereira, Tiago S. R. Santos, Luciana B. Chiarini, et al.From:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 11, 20125,678 words Article 1560LAuthor(s): Vitor L. A. Lima 1 , Felipe Dias 2 , Rodrigo D. Nunes 2 , Luiza O. Pereira 3 , Tiago S. R. Santos 2 , Luciana B. Chiarini 4 , Tadeu D. Ramos 2 , Bernardo J. Silva-Mendes 2 , Jonas Perales 5 , Richard H....

• Probing the Effect of [Ag.sub.2]S Quantum Dots on Human Serum Albumin Using Spectral Techniques

  Authors:Yiying Fu, Enli Guan, Jiangong Liang, Guolan Ren, and Lu ChenFrom:Journal of Nanomaterials (Vol. 2017) Peer-Reviewed

  Annual 20174,411 words Article 1390LThe understanding of the interaction between protein and quantum dots (QDs) has significant implications for biological applications of QDs. Herein, we studied the effect of [Ag.sub.2]S QDs on human serum albumin (HSA)...

• Pyoverdine, the major siderophore in Pseudomonas aeruginosa, evades NGAL recognition

  Authors:Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, and Susu M. ZughaierFrom:Interdisciplinary Perspectives on Infectious DiseasesPeer-Reviewed

  September-October 20125,315 words Article 1370LPseudomonas aeruginosa is the most common pathogen that persists in the cystic fibrosis lungs. Bacteria such as P. aeruginosa secrete siderophores (iron-chelating molecules) and the host limits bacterial growth by...

• Growth performance and small intestinal morphology of native chickens after feed supplementation with tryptophan and threonine during the starter phase.

  Authors:Charles V. Lisnahan and Oktovianus R. NahakFrom:Veterinary World (Vol. 13, Issue 12)

  Dec. 20204,725 words Article 1430LBackground and Aim: The amino acid content of feed can affect growth performance of poultry during the first 6 weeks of life or the starter phase. Unlike for broiler and layer chickens, there is no information concerning...

• Real-time monitoring of hydrogen peroxide vapour decontamination of bacterial spores by means of UV fluorimetry/Vesinikperoksiidaurul pohineva bakterispooride puhastusprotseduuri seire reaalajas UV-fluoromeetri abil.

  Authors:Ott Rebane, Harri Hakkarainen, Marco Kirm, Larisa Poryvkina, Innokenti Sobolev, Panu Wilska, et al.From:Proceedings of the Estonian Academy of Sciences (Vol. 70, Issue 1) Peer-Reviewed

  Mar. 20214,828 words Article 1600LThis study is devoted to the development of a UV fluorimetry sensor capable of real-time monitoring of the decontamination process of microbiological pathogens by hydrogen peroxide vapour (HPV) treatment. The sensor is...

• Biosynthetic Gene Cluster for the Cladoniamides, Bis-Indoles with a Rearranged Scaffold

  Author:Katherine S. RyanFrom:PLoS ONE (Vol. 6, Issue 8) Peer-Reviewed

  Aug. 18, 20117,029 words Article 1450LThe cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole...

• Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

  Authors:Anna P. Lucarelli, Silvia Buroni, Maria R. Pasca, Menico Rizzi, Andrea Cavagnino, Giovanna Valentini, et al.From:PLoS ONE (Vol. 5, Issue 11) Peer-Reviewed

  Nov. 15, 20108,108 words Article 1550LThe selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Currently, there is an urgent need for new...

• Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel Disease

  Authors:Tadakazu Hisamatsu, Susumu Okamoto, Masaki Hashimoto, Takahiko Muramatsu, Ayatoshi Andou, Michihide Uo, et al.From:PLoS ONE (Vol. 7, Issue 1) Peer-Reviewed

  Jan. 31, 20124,588 words Article 1490LBackground Inflammatory bowel disease (IBD) is a chronic intestinal disorder that is associated with a limited number of clinical biomarkers. In order to facilitate the diagnosis of IBD and assess its disease...

• Comparative Study of the Fatty Acid Binding Process of a New FABP from Cherax quadricarinatus by Fluorescence Intensity, Lifetime and Anisotropy

  Authors:Jiayao Li, Etienne Henry, Lanmei Wang, Olivier Delelis, Huan Wang, Francoise Simon, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 21, 201212,943 words Article 1610LFatty acid-binding proteins (FABPs) are small cytosolic proteins, largely distributed in invertebrates and vertebrates, which accomplish uptake and intracellular transport of hydrophobic ligands such as fatty acids....

• Crystal Structure of BamB from Pseudomonas aeruginosa and Functional Evaluation of Its Conserved Structural Features

  Authors:Katarina Bartos Jansen, Susan Lynn Baker, and Marcelo Carlos SousaFrom:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 26, 20127,318 words Article 1450LThe assembly of [beta]-barrel Outer Membrane Proteins (OMPs) in the outer membrane is essential for Gram-negative bacteria. The process requires the [beta]-Barrel Assembly Machine (BAM), a multiprotein complex that, in...

• Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins

  Authors:Si Min Zhang, Alenka Jejcic, James P. Tam, and Anders VahlneFrom:PLoS ONE (Vol. 10, Issue 7) Peer-Reviewed

  July 31, 201510,948 words Article 1570LThe membrane proximal external region (MPER) is a highly conserved membrane-active region located at the juxtamembrane positions within class I viral fusion glycoproteins and essential for membrane fusion events during...

• [beta].sub.2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

  Authors:Sophia C. Goodchild, Tania Sheynis, Rebecca Thompson, Kevin W. Tipping, Wei-Feng Xue, Neil A. Ranson, et al.From:PLoS ONE (Vol. 9, Issue 8) Peer-Reviewed

  Aug. 6, 201413,346 words Article 1700LAlthough the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases....

• Modulating the Structure of EGFR with UV Light: New Possibilities in Cancer Therapy

  Authors:Manuel Correia, Viruthachalam Thiagarajan, Isabel Coutinho, Gnana Prakash Gajula, Steffen B. Petersen, and Maria Teresa Neves-PetersenFrom:PLoS ONE (Vol. 9, Issue 11) Peer-Reviewed

  Nov. 11, 201411,821 words Article 1500LThe epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. EGFR is activated upon binding to e.g. epidermal growth factor (EGF), leading to cell survival, proliferation and...

• Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1.

  Authors:Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, et al.From:Journal of Hematology & Oncology (Vol. 14, Issue 1) Peer-Reviewed

  Sept. 25, 20212,117 words Article 1330LThe 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is...

• [alpha]-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions

  Author:Diane C ChuganiFrom:Biomarkers in Medicine (Vol. 5, Issue 5) Peer-Reviewed

  Oct. 20115,885 words Report 1550LAuthor(s): Diane C Chugani 1 KEYWORDS : [alpha]-methyl-L-tryptophan; brain tumors; epilepsy; indoleamine 2,3-dioxygenase; kynurenine; serotonin; tuberous sclerosis complex The original rationale for applying...

• Selective processing of social threat cues following acute tryptophan depletion

  Authors:Marcus R. Munafo, Gail Hayward, and Catherine HarmerFrom:Journal of Psychopharmacology (Vol. 20, Issue 1) Peer-Reviewed

  Jan. 20064,741 words Clinical report 1830LAbstract The aim of the present study was to investigate the effects of low dose tryptophan depletion on recovered depressed patients both on and off antidepressant medication on an emotional Stroop task using social...

• Inhibition of the B. subtilis Regulatory Protein TRAP by the TRAP-Inhibitory Protein, AT

  Authors:Angela Valbuzzi and Charles YanofskyFrom:Science (Vol. 293, Issue 5537) Peer-Reviewed

  Sept. 14, 20012,584 words Article An anti-TRAP (AT) protein, a factor of previously unknown function, conveys the metabolic signal that the cellular transfer RNA for tryptophan ([tRNA.sup.Trp]) is predominantly uncharged. Expression of the operon...

• SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses

  Authors:Cortez McBerry, Rosa Maria Salazar Gonzalez, Nathaniel Shryock, Alexandra Dias, and Julio AlibertiFrom:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 5, 20126,599 words Article 1500LAuthor(s): Cortez McBerry, Rosa Maria Salazar Gonzalez, Nathaniel Shryock, Alexandra Dias, Julio Aliberti * Introduction Lipoxins (LX) are trihydroxytetraene-containing arachidonic acid mediators that...

• High Fat Diet Alters Lactation Outcomes: Possible Involvement of Inflammatory and Serotonergic Pathways

  Authors:Laura L. Hernandez, Bernadette E. Grayson, Ekta Yadav, Randy J. Seeley, and Nelson D. HorsemanFrom:PLoS ONE (Vol. 7, Issue 3) Peer-Reviewed

  Mar. 5, 20125,153 words Article 1440LAuthor(s): Laura L. Hernandez 1 , 2 , * , Bernadette E. Grayson 3 , Ekta Yadav 1 , Randy J. Seeley 3 , Nelson D. Horseman 1 Introduction Obesity has profound negative impacts on numerous physiological processes....