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• A Web-Based Platform for Designing Vaccines against Existing and Emerging Strains of Mycobacterium tuberculosis

  Authors:Sandeep Kumar Dhanda, Pooja Vir, Deepak Singla, Sudheer Gupta, Shailesh Kumar, and Gajendra P. S. RaghavaFrom:PLoS ONE (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 20, 20164,938 words Report 1370LDevelopment of an effective vaccine against drug-resistant Mycobacterium tuberculosis (Mtb) is crucial for saving millions of premature deaths every year due to tuberculosis. This paper describes a web portal developed...

• Oral immunogenicity of plant-made Mycobacterium tuberculosis ESAT6 and CFP10

  Authors:Elena A. Uvarova, Pavel A. Belavin, Natalya V. Permyakova, Alla A. Zagorskaya, Olesya V. Nosareva, Almagul A. Kakimzhanova, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20144,834 words Report 1430LTwo lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the...

• TB vaccines: the paradigms they are a-shifting

  Authors:David N McMurray and Lan H LyFrom:Expert Review of Vaccines (Vol. 8, Issue 12) Peer-Reviewed

  Dec. 20092,490 words Editorial 1700LAuthor(s): David N McMurray [[dagger]] 1 , Lan H Ly 2 Traditional roadblocks to effective TB control (e.g., lack of attention to the disease, lack of resources, antiquated diagnostic tests, lack of patient compliance...

• Synergy between tuberculin skin test and proliferative T cell responses to PPD or cell-membrane antigens of Mycobacterium tuberculosis for detection of latent TB infection in a high disease-burden setting

  Authors:Suvrat Arya, Shashi Kant Kumar, Alok Nath, Prerna Kapoor, Amita Aggarwal, Ramnath Misra, et al.From:PLoS ONE (Vol. 13, Issue 9) Peer-Reviewed

  Sept. 24, 20185,972 words Report 1380LTuberculin skin test (TST) is used most widely for the detection of latent tuberculosis infection (LTBI), even though evidences suggest that it could be underreporting the prevalence of LTBI particularly in high...

• Repeated aerosolized-boosting with gamma-irradiated mycobacterium bovis BCG confers improved pulmonary protection against the hypervirulent mycobacterium tuberculosis strain HN878 in mice

  Authors:Seung Bin Cha, Woo Sik Kim, Jong-Seok Kim, Hongmin Kim, Kee Woong Kwon, Seung Jung Han, et al.From:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 28, 20159,635 words Report 1610LMycobacterium bovis bacillus Calmette-Guerin (BCG), the only licensed vaccine, shows limited protection efficacy against pulmonary tuberculosis (TB), particularly hypervirulent Mycobacterium tuberculosis (Mtb) strains,...

• Uso de tuberculina en caninos para buscar reservorios de Mycobacterium bovis

  Authors:Carlos Bernal Suarez, Sebastián Martínez-Garcia, and Roy José Andrade-BecerraFrom:Ciencia y Agricultura (Vol. 10, Issue 2) Peer-Reviewed

  July-December 20131,436 words Article Objetivo. Utilizar la prueba de tuberculina en caninos para buscar reservorios de Mycobacterium bovis. Materiales y métodos. Se utilizó la prueba comparada en los caninos que dieron positivo a la PPD ano-caudal, y la...

• Prime-boost approaches to tuberculosis vaccine development

  Authors:Neha Dalmia and Alistair J. RamsayFrom:Expert Review of Vaccines (Vol. 11, Issue 10) Peer-Reviewed

  Oct. 201211,724 words Report 1710LAuthor(s): Neha Dalmia 1 , Alistair J Ramsay [*] 1 Keywords : BCG; lung immunity; mucosal delivery; prime-boost; recombinant viral vectors; systems biology; tuberculosis; T cell; vaccine TB is a global...

• Diagnosis of MDR-TB: a developing world problem on a developed world budget

  Author:Mark FisherFrom:Expert Review of Molecular Diagnostics (Vol. 2, Issue 2) Peer-Reviewed

  Mar. 1, 20025,604 words Report 1380LThe resurgence of tuberculosis worldwide has been accompanied by an increase in the incidence of multidrug-resistant tuberculosis on all continents. While significant advances have been made in the rapid and accurate...

• Drug-resistant Mycobacterium tuberculosis in California, 1991 to 1992

  Authors:Denise Koo, Sarah Royce, and George W. RutherfordFrom:The Western Journal of Medicine (Vol. 163, Issue 5) Peer-Reviewed

  Nov. 19953,464 words Article To determine the proportion and distribution of drug-resistant Mycobacterium tuberculosis in California, we surveyed all California counties for drug-susceptibility test results for initial isolates from tuberculosis...

• PPE38 Protein of Mycobacterium tuberculosis Inhibits Macrophage MHC Class I Expression and Dampens CD8+ T Cell Responses

  Authors:Lu Meng, Jingfeng Tong, Hui Wang, Chengwu Tao, Qinglan Wang, Chen Niu, et al.From:Frontiers in Cellular and Infection MicrobiologyPeer-Reviewed

  Mar. 13, 2017237 words Brief article, Repor... 1480LAuthor(s): Lu Meng, Jingfeng Tong, Hui Wang, Chengwu Tao, Qinglan Wang, Chen Niu, Xiaoming Zhang, Qian Gao Suppression of CD8+ T cell activation is a critical mechanism used by Mycobacterium tuberculosis (MTB) to...

• High Prevalence of Beijing and EAI4-VNM Genotypes among M. tuberculosis Isolates in Northern Vietnam: Sampling Effect, Rural and Urban Disparities

  Authors:Van Anh Thi Nguyen, Marc Choisy, Duy Hung Nguyen, Thanh Hoa Thi Tran, Kim Lien Thi Pham, Phuong Thao Thi Dinh, et al.From:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 24, 20127,697 words Report 1540LAuthor(s): Van Anh Thi Nguyen 1 , * , Marc Choisy 2 , Duy Hung Nguyen 3 , Thanh Hoa Thi Tran 1 , Kim Lien Thi Pham 1 , Phuong Thao Thi Dinh 1 , Jules Philippe 1 , Thai Son Nguyen 4 , Minh Ly Ho 1 , Sang Van Tran 5 ,...

• MptpB Promotes Mycobacteria Survival by Inhibiting the Expression of Inflammatory Mediators and Cell Apoptosis in Macrophages

  Authors:Lingbo Fan, Xiaoyu Wu, Chunyan Jin, Fengge Li, Sidong Xiong, and Yuanshu DongFrom:Frontiers in Cellular and Infection MicrobiologyPeer-Reviewed

  May 25, 2018194 words Brief article, Repor... 1380LAuthor(s): Lingbo Fan, Xiaoyu Wu, Chunyan Jin, Fengge Li, Sidong Xiong, Yuanshu Dong Tuberculosis is a severe contagious disease caused by Mycobacterium tuberculosis (Mtb). To develop new vaccines and medicine...

• Tuberculosis: nine questions physicians often ask

  Authors:Soheila Vossough and Lee B. ReichmanFrom:Consultant (Vol. 37, Issue 3) Peer-Reviewed

  Mar. 19972,508 words Article Tuberculosis caused by Mycobacterium tuberculosis bacteria have emerged as one of the serious problems in the world. Screening, testing, and treatment of this disease were presented. The technique and importance of...

• Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

  Authors:Michael D. Stutz, Samar Ojaimi, Gregor Ebert, and Marc PellegriniFrom:Frontiers in ImmunologyPeer-Reviewed

  May 28, 2018253 words Brief article 1700LAuthor(s): Michael D. Stutz, Samar Ojaimi, Gregor Ebert, Marc Pellegrini The dwindling list of antimicrobial agents exhibiting broad efficacy against clinical strains of Mycobacterium tuberculosis (Mtb) has forced...

• Differential skewing of donor-unrestricted and [gamma[delta] T cell repertoires in tuberculosis-infected human lungs.

  Authors:Paul Ogongo, Adrie J.C. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, et al.From:Journal of Clinical Investigation (Vol. 130, Issue 1) Peer-Reviewed

  Jan. 202011,656 words Article 1410LUnconventional T cells that recognize mycobacterial antigens are of great interest as potential vaccine targets against tuberculosis (TB). This includes donor-unrestricted T cells (DURTs), such as mucosa-associated...

• Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan

  Authors:Yassir A. Shuaib, Eltahir A.G. Khalil, Lothar H. Wieler, Ulrich E. Schaible, Mohammed A. Bakheit, Saad E. Mohamed-Noor, et al.From:Emerging Infectious Diseases (Vol. 26, Issue 3) Peer-Reviewed

  Mar. 20205,253 words Report 1440LPathogen-based factors associated with tuberculosis (TB) in eastern Sudan are not well defined. We investigated genetic diversity, drug resistance, and possible transmission clusters of Mycobacterium tuberculosis...

• Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection.

  Authors:Rachel Tanner, Iman Satti, Stephanie A. Harris, Matthew K. O'Shea, Deniz Cizmeci, Daniel O'Connor, et al.From:Frontiers in ImmunologyPeer-Reviewed

  Jan. 10, 2020343 words Brief article 1770LAuthor(s): Rachel Tanner, Iman Satti, Stephanie A. Harris, Matthew K. O'Shea, Deniz Cizmeci, Daniel O'Connor, Agnieszka Chomka, Magali Matsumiya, Rachel Wittenberg, Angela M. Minassian, Joel Meyer, Helen A. Fletcher,...

• A study of IgA antibody response to different Mycobacterium tuberculosis antigens in the diagnosis and monitoring of pulmonary tuberculosis

  Authors:Janaina Miranda Bezerra, Sandra Trevisan Beck, Kelly Aparecida Kanunfre, Olavo Munhoz Leite, and Antonio Walter FerreiraFrom:The Brazilian Journal of Infectious Diseases (Vol. 13, Issue 1) Peer-Reviewed

  Feb. 20094,104 words Report 1490LWe evaluated the performance of the ELISA technique in the detection of IgA antibodies against different Mycobacterium tuberculosis antigenic preparations in serum samples from 49 patients with pulmonary tuberculosis...

• Molecular epidemiology and genotyping of Mycobacterium tuberculosis isolated in Baghdad

  Authors:Ruqaya Mustafa Ali, Alberto Trovato, David Couvin, Amina N. Al-Thwani, Emanuele Borroni, Fahim H. Dhaer, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20144,584 words Report 1570LTuberculosis (TB) remains a major health problem in Iraq but the strains responsible for the epidemic have been poorly characterized. Our aim was to characterize the TB strains circulating in Bagdad (Iraq). A total of...

• Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31[R] against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

  Authors:Claus Aagaard, Truc Thi Kim Thanh Hoang, Angelo Izzo, Rolf Billeskov, JoLynn Troudt, Kim Arnett, et al.From:PLoS ONE (Vol. 4, Issue 6) Peer-Reviewed

  June 16, 20095,995 words Article 1500LBackground Previously we have shown that Ag85B-TB10.4 is a highly efficient vaccine against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic liposomes. Another Th1 inducing adjuvant, which has...