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    Academic Journals

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• Targeting retinoblastoma protein offers therapeutic opportunities for peripheral nerve injury

  Authors:Anand Krishnan and Douglas W ZochodneFrom:Future Neurology (Vol. 9, Issue 5) Peer-Reviewed

  Sept. 20141,814 words Report 1720LAuthor(s): Anand Krishnan aff1 , Douglas W Zochodne [*] aff1 KEYWORDS axon regeneration; neuron; peripheral nerve injury; retinoblastoma protein; sciatic nerve Peripheral nerve injury is common. Severed...

• Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

  From:Nature Medicine (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 200926 words Brief article 850LGain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Sanada, M. et al. Nature 460, 904-908. Loss of heterozygosity uncovers a gain-of-function mutation that promotes tumorigenesis....

• Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors

  Authors:Raquel Seruca, Sergia Velho, Carla Oliveira, Marina Leite, Paulo Matos, and Peter JordanFrom:Expert Review of Gastroenterology & Hepatology (Vol. 3, Issue 1) Peer-Reviewed

  Feb. 20093,853 words Editorial Author(s): Raquel Seruca [[dagger]] 1 , Sérgia Velho 2 , Carla Oliveira 3 , Marina Leite 4 , Paulo Matos 5 , Peter Jordan 6 Colorectal cancer (CRC) represents one of the leading causes of cancer mortality in the...

• Subcellular dynamics of the VHL tumor suppressor: on the move for HIF degradation

  Authors:Mireille Khacho and Stephen LeeFrom:Future Oncology (Vol. 5, Issue 1) Peer-Reviewed

  Feb. 20096,439 words Report Author(s): Mireille Khacho 1 , Stephen Lee [[dagger]] 2 Keywords: Keywords 5,6-dichlorobenzimidazole (DRB); actinomycin D; E3 ubiquitin ligase; O 2 - and pH-dependent HIF regulation; pH-dependent nucleolar...

• p53 antibody levels sensitive for detecting prostate cancer

  From:Expert Review of Anticancer Therapy (Vol. 4, Issue 1) Peer-Reviewed

  Feb. 1, 2004299 words Brief article, Repor... 1460LJapanese researchers have reported that measuring serum p53 antibody (p53-Ab) along with prostate-specific antigen (PSA) levels appears to be a sensitive way to identify prostate cancer in patients with negative results...

• Autocrine lysophosphatidic acid signaling activates [beta]-catenin and promotes lung allograft fibrosis

  Authors:Pengxiu Cao, Yoshiro Aoki, Linda Badri, Natalie M. Walker, Casey M. Manning, Amir Lagstein, et al.From:Journal of Clinical Investigation (Vol. 127, Issue 4) Peer-Reviewed

  Apr. 20179,374 words Report 1430LTissue fibrosis is the primary cause of long-term graft failure after organ transplantation. In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed...

• PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

  Authors:Seyedmehdi Shojaee, Lai N. Chan, Maike Buchner, Valeria Cazzaniga, Kadriye Nehir Cosgun, Huimin Geng, et al.From:Nature Medicine (Vol. 22, Issue 4) Peer-Reviewed

  Apr. 20168,198 words Report 1510LPhosphatase and tensin homolog (PTEN) is a negative regulator of the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathway and a potent tumor suppressor in many types of cancer. To test a...

• Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

  Authors:Petrus R. de Jong, Naoki Takahashi, Alexandra R. Harris, Jihyung Lee, Samuel Bertin, James Jeffries, et al.From:Journal of Clinical Investigation (Vol. 124, Issue 9) Peer-Reviewed

  Sept. 20148,909 words Report 1370LThe intestinal epithelium has a high rate of turnover, and dysregulation of pathways that regulate regeneration can lead to tumor development; however, the negative regulators of oncogenic events in the intestinal...

• Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer

  Authors:Yating Cheng, Parisa Imanirad, Indira Jutooru, Erik Hedrick, Un-Ho Jin, Aline Rodrigues Hoffman, et al.From:PLoS ONE (Vol. 13, Issue 2) Peer-Reviewed

  Feb. 1, 20186,985 words Report 1580LAuthor(s): Yating Cheng 1, Parisa Imanirad 1, Indira Jutooru 1, Erik Hedrick 1, Un-Ho Jin 1, Aline Rodrigues Hoffman 2, Jeann Leal de Araujo 2, Benjamin Morpurgo 3, Andrei Golovko 3, Stephen Safe 1,* Introduction...

• Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells

  Authors:Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, and Kyong-Ah YoonFrom:PLoS ONE (Vol. 13, Issue 2) Peer-Reviewed

  Feb. 20, 20183,264 words Report 1350LAuthor(s): Daseul Yoon 1, Kieun Bae 1, Min-Kyeong Lee 2, Jin Hee Kim 3, Kyong-Ah Yoon 1,* Introduction Galanin is a neuropeptide with a number of physiological actions that is distributed throughout the central...

• The role of NRAGE subcellular location and epithelial-mesenchymal transition on radiation resistance of esophageal carcinoma cell

  Authors:Xiaojing Chang, Xiaoying Xue, Yafang Zhang, Ge Zhang, Huandi Zhou, Yanling Yang, et al.From:Journal of Cancer Research and Therapeutics (Vol. 14, Issue 1) Peer-Reviewed

  January-March 20183,842 words Report 1570LByline: Xiaojing. Chang, Xiaoying. Xue, Yafang. Zhang, Ge. Zhang, Huandi. Zhou, Yanling. Yang, Yuge. Ran, Zhiqing. Xiao, Xiaohui. Ge, Huizhi. Liu Background: Neurotrophin receptor-interacting MAGE homolog (NRAGE) has...

• The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

  Authors:Emily E. Bosco, Ying Wang, Huan Xu, Jack T. Zilfou, Karen E. Knudsen, Bruce J. Aronow, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 1) Peer-Reviewed

  Jan. 20077,647 words Article 1490LThe retinoblastoma tumor suppressor (RB) protein is functionally inactivated in the majority of human cancers and is aberrant in one-third of all breast cancers. RB regulates [G.sub.1]/S-phase cell-cycle progression and...

• Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification

  Authors:Yu-Chang Huang, Hitomi Hasegawa, Shin-Wei Wang, Chia-Chen Ku, Ying-Chu Lin, Shyh-Shin Chiou, et al.From:Journal of Biomedicine and BiotechnologyPeer-Reviewed

  Annual 20119,175 words Report 1480LTranscription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2...

• Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent Modifications.

  Authors:Yang Jiao, Yunpeng Feng, and Xiuli WangaFrom:Biochemistry (Moscow) (Vol. 83, Issue 11) Peer-Reviewed

  Nov. 20185,012 words Report 1440LCDKN2A is one of the most studied tumor suppressor genes. It encodes the p16-INK4a protein that plays a critical role in the cell cycle progression, differentiation, senescence, and apoptosis. Mutations in CDKN2A or...

• Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma *

  Authors:Ju Hye Shin, Shin Myung Kang, Young Sam Kim, Dong Hwan Shin, Joon Chang, Sung Kyu Kim, et al.From:Chest (Vol. 128, Issue 4) Peer-Reviewed

  Oct. 20052,998 words Article Background: A recent cytogenetic analysis of non-small cell lung cancer revealed hot-spot regions for deletion on the long arm of chromosome 5 and suggested the existence of putative tumor suppressor genes in that...

• The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome

  Authors:Sanambar Sadighi, Mohammad Zokaasadi, Amir Kasaeian, Somaye Maghsudi, Issa Jahanzad, and Hosein Kamranzadeh FumaniFrom:PLoS ONE (Vol. 12, Issue 8) Peer-Reviewed

  Aug. 3, 20173,208 words Report 1300LBackground P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is...

• ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis

  Authors:Yan Jiang, Chen-Yang Zhao, Li-Chun Cheng, Bing Xu, and Hui-Yi LvFrom:Hereditary Cancer in Clinical Practice (Vol. 15, Issue 1) Peer-Reviewed

  June 13, 20173,116 words Report 1270LAdenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer...

• Targeting mutant p53 in cancer: the latest insights

  Authors:Silvia Di Agostino, Giulia Fontemaggi, Sabrina Strano, Giovanni Blandino, and Gabriella D'OraziFrom:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  July 5, 20191,366 words Report 1650LThis commentary wishes to highlight the latest discoveries in the mutant p53 field that have been discussed in the 8th p53 Mutant Workshop 2019, held in Lyon. TP53 mutant (mutp53) proteins are involved in the...

• Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53

  Authors:Phong Lu, Erica R. Vander Mause, Katherine E. Redd Bowman, Sarah M. Brown, Lisa Ahne, and Carol S. LimFrom:Journal of Ovarian Research (Vol. 12, Issue 1) Peer-Reviewed

  May 15, 20198,627 words Report 1470LBackground While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We...

• In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites

  Authors:Lina Sun, Ge Zhang, Zongfang Li, Tusheng Song, Chen Huang, and Lusheng SiFrom:Journal of Experimental & Clinical Cancer Research (Vol. 27) Peer-Reviewed

  Sept. 8, 20084,542 words Article 1380LBackground Infected cells recognize viral replication as a DNA damage stress and elicit the host surveillance mechanism to anti-virus infection. Modulation of the activity of tumor suppressor p53 is a key event in...