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    Academic Journals

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• Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation

  Authors:Jia Shao, Vitnary Choe, Haili Cheng, Yien Che Tsai, Allan M. Weissman, Shiwen Luo, et al.From:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20144,259 words Report 1410LPrion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious...

• The new landscape of protein Ubiquitination: proteome-wide identification of ubiquitination events reveals their functional classes and identifies substrates for ubiquitin ligases

  Authors:Guoqiang Xu and Samie R. JaffreyFrom:Nature Biotechnology (Vol. 29, Issue 12) Peer-Reviewed

  Dec. 20111,416 words Report 1420LUbiquitination is not just about targeting proteins for degradation in the proteasome. Many properties of proteins, such as their localization, binding partners and activity, are controlled by adding and removing...

• A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity

  Authors:Tracy R. Rosebrock, Lirong Zeng, Jennifer J. Brady, Robert B. Abramovitch, Fangming Xiao, and Gregory B. MartinFrom:Nature (Vol. 448, Issue 7151) Peer-Reviewed

  July 19, 20075,779 words Report 1420LAuthor(s): Tracy R. Rosebrock [1, 2]; Lirong Zeng [1]; Jennifer J. Brady [1]; Robert B. Abramovitch [1, 2]; Fangming Xiao [1]; Gregory B. Martin (corresponding author) [1, 2] Many bacterial pathogens of plants and...

• The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control

  Authors:Hongyi Wu, Davis T.W. Ng, Ian Cheong, and Paul MatsudairaFrom:PLoS ONE (Vol. 15, Issue 5) Peer-Reviewed

  May 13, 20208,502 words Report 1430LAuthor(s): Hongyi Wu 1,2,*, Davis T. W. Ng 1, Ian Cheong 1,2,*, Paul Matsudaira 2,3,* Introduction Protein quality control (QC) pathways operate in all compartments of eukaryotic cells to eliminate misfolded...

• MALT1-Ubiquitination Triggers Non-Genomic NF-[kappa]B/IKK Signaling upon Platelet Activation

  Authors:Zubair A. Karim, Hari Priya Vemana, and Fadi T. KhasawnehFrom:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 6, 20156,581 words Report 1370LWe have recently shown that IKK complex plays an important non-genomic role in platelet function, i.e., regulates SNARE machinery-dependent membrane fusion. In this connection, it is well known that MALT1, whose...

• The ubiquitin system

  Author:Deepa NathFrom:Nature (Vol. 458, Issue 7237) Peer-Reviewed

  Mar. 26, 2009247 words Brief article, Edito... 1370LThe destruction of proteins is as important as their synthesis for the maintenance of protein homeostasis in cells. In eukaryotes, the ubiquitin-proteasome system is responsible for most of this protein degradation: the...

• Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

  Authors:Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, et al.From:Nature (Vol. 455, Issue 7211) Peer-Reviewed

  Sept. 18, 20086,429 words Report 1450LDeubiquitinating enzymes (DUBS) remove ubiquitin from conjugated substrates to regulate various cellular processes. The Z[n.sup.2+]-dependent DUBS AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving...

• Atomic structure of the APC/C and its mechanism of protein ubiquitination

  Authors:Leifu Chang, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin, and David BarfordFrom:Nature (Vol. 522, Issue 7557) Peer-Reviewed

  June 25, 20159,639 words Report 1430LThe anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by coactivator subunits, phosphorylation, the mitotic checkpoint...

• TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene

  Authors:Barbara Czub, Amna Z. Shah, Giovanna Alfano, Przemyslaw M. Kruczek, Christina F. Chakarova, and Shomi S. BhattacharyaFrom:PLoS ONE (Vol. 11, Issue 2) Peer-Reviewed

  Feb. 12, 20169,263 words Report 1470LThe significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of neurodegenerative diseases, including retinal dystrophies. TOPORS, a dual E3 ubiquitin and SUMO1...

• Inhibitors for E3 ubiquitin ligases: two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules

  Authors:John R. Lydeard and J. Wade HarperFrom:Nature Biotechnology (Vol. 28, Issue 7) Peer-Reviewed

  July 20101,661 words Report 1560LThe ubiquitin-proteasome system for protein degradation regulates a wide array of cellular processes, and its misregulation has been linked to numerous human pathologies. General inhibitors of the proteasome and of the...

• A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

  Authors:Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, et al.From:Nature Medicine (Vol. 24, Issue 2) Peer-Reviewed

  Feb. 201811,209 words Report 1510LAuthor(s): Marc L Hyer [1]; Michael A Milhollen (corresponding author) [1]; Jeff Ciavarri [1]; Paul Fleming [1]; Tary Traore [1]; Darshan Sappal [1]; Jessica Huck [1]; Judy Shi [1]; James Gavin [1]; Jim Brownell [1]; Yu...

• Lenalidomide induces ubiquitination and degradation of CK1[alpha] in del(5q) MDS

  Authors:Jan Kronke, Emma C. Fink, Paul W. Hollenbach, Kyle J. MacBeth, Slater N. Hurst, Namrata D. Udeshi, et al.From:Nature (Vol. 523, Issue 7559) Peer-Reviewed

  July 9, 20159,687 words Report 1530LLenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1...

• Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

  Authors:Elena Kudryashova, Irina Kramerova, and Melissa J. SpencerFrom:Journal of Clinical Investigation (Vol. 122, Issue 5) Peer-Reviewed

  May 2012 Report 1380L

• FOXO factors: a matter of life and death

  Authors:Haojie Huang and Donald J TindallFrom:Future Oncology (Vol. 2, Issue 1) Peer-Reviewed

  Feb. 20064,972 words Article Author(s): Haojie Huang 1 , Donald J Tindall [2[dagger]] 2 Keywords: Akt; FOXO proteins; FOXO1; FOXO3a; FOXO4; phosphorylation; prostate cancer; proteasome degradation; PTEN; Skp2; ubiquitination Biomedical...

• X.M. Sun et al., "Caspase activation inhibits proteasome function during apoptosis," Mol Cell, 14:81-93, April 9, 2004

  Author:Ding XueFrom:The Scientist (Vol. 18, Issue 11) Peer-Reviewed

  June 7, 200457 words Brief article This paper reports a novel finding that the proteasome is inactivated by caspases at an early stage of apoptosis, which provides feed-forward amplification of apoptotic signals.... Caspase-dependent inactivation of the...

• The Ubiquitin system in cancer: is protein degradation or preservation a key to saving patients?

  Author:Douglas SteinbergFrom:The Scientist (Vol. 17, Issue 18) Peer-Reviewed

  Sept. 22, 20032,053 words Article Last May, the US Food and Drug Administration approved the first weapon in what could become a brand new arsenal against cancer. That weapon is Velcade (bortezomib), a drug that inhibits an intracellular...

• A new twist to the cell cycle: researchers have found that the timed destruction of key proteins plays a critical role in regulating the cell cycle

  Author:Marcia BarinagaFrom:Science (Vol. 269, Issue 5224) Peer-Reviewed

  Aug. 4, 19952,175 words Article Researchers are focusing on the role of sudden protein destruction, or proteolysis, in the regulation of the cell cycle. They have discovered that a molecule named ubiquitin plays an important part in initiating...

• A U-Box E3 Ubiquitin Ligase, PUB20, Interacts with the Arabidopsis G-Protein [beta] Subunit, AGB1

  Authors:Shio Kobayashi, Daisuke Tsugama, Shenkui Liu, and Tetsuo TakanoFrom:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 15, 20124,098 words Article 1420LAuthor(s): Shio Kobayashi 1 , Daisuke Tsugama 1 , Shenkui Liu 2 , Tetsuo Takano 1 , * Introduction Heterotrimeric G-proteins (G-proteins) are evolutionarily conserved plasma membrane-bound proteins that are...

• Ubiquitylation of Terminal Deoxynucleotidyltransferase Inhibits Its Activity

  Authors:So Maezawa, Rie Fukushima, Toyofumi Matsushita, Tomoyoshi Kato, Yoshiki Takagaki, Yoshihiro Nishiyama, et al.From:PLoS ONE (Vol. 7, Issue 7) Peer-Reviewed

  July 11, 20129,030 words Article 1390LAuthor(s): So Maezawa * , Rie Fukushima, Toyofumi Matsushita, Tomoyoshi Kato, Yoshiki Takagaki, Yoshihiro Nishiyama, Sachiko Ando, Takuro Matsumoto, Kousuke Kouda, Takahide Hayano, Masahiro Suzuki, Kotaro Koiwai, Osamu...

• Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments

  Authors:BethAnn McLaughlin, Matthew A. Buendia, Tommy P. Saborido, Amy M. Palubinsky, Jeannette N. Stankowski, and Gregg D. StanwoodFrom:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 11, 20125,655 words Article 1550LAuthor(s): BethAnn McLaughlin 1 , 2 , 3 , * , Matthew A. Buendia 2 , Tommy P. Saborido 2 , Amy M. Palubinsky 3 , 4 , Jeannette N. Stankowski 4 , Gregg D. Stanwood 2 , 3 Introduction Heat shock proteins (HSPs) are...