Assessment of the Prevalence of Diabetic Gastroparesis and Validation of Gastric Emptying Scintigraphy for Diagnosis/Diyabetik Gastroparezi Prevalansi ve Tanisinda Mide Vosalma Sintigrafisinin Gecerliliginin Arastirilmasi

Citation metadata

Publisher: Galenos Yayinevi Tic. Ltd.
Document Type: Report
Length: 4,544 words
Lexile Measure: 1460L

Document controls

Main content

Abstract :

Objective: Gastroparesis is defined as delayed gastric emptying and is a common medical condition in diabetic patients. Scintigraphy is commonly used as a standard diagnostic procedure for the quantitative assessment of gastroparesis. The aims of this study were to determine an optimum imaging time for the diagnosis of gastroparesis, to assess the prevalence of gastroparesis, to evaluate the correlation between endoscopy and scintigraphy findings as well as the correlation between gastric emptying with patient genders, blood glucose concentration, and functional dyspepsia. Methods: Gastric emptying was assessed in 50 diabetic patients with a mean age of 50.16 years. For evaluation of gastric emptying, a test meal containing 2 pieces of toast, 120 cc non-labeled water and fried egg labeled with 1 mCi of [.sup.99m] Tc was given to each patient. The scintigraphy was performed immediately after ingestion and was repeated at 1, 1.5, 2 and 4 hours after ingestion. In some patients, an additional 90-minute dynamic scan was also acquired. Results: The prevalence of gastroparesis in this study population was determined as 64%. Also, the results of this study revealed that a 4-hour scan after ingestion is more relevant than a 90-minute dynamic scan for the evaluation of delayed gastric emptying. There was no statistically significant difference between 1-hour and 2-hour scans, 1-hour and 90-minute scans, 2-hour and 90-minute scans, 2-hour and 4-hour scans. Likewise there was no significant correlation between blood glucose levels, gender and calculated values of gastric emptying time in all groups. Conclusion: According to our findings, it can be suggested that the prevalence of gastroparesis is higher than that mentioned in some previous studies. Also, this study indicates that a gastric emptying scintigraphy at 2 and 4 hours after meal ingestion might provide the anticipated clinical information in diabetic patients with dyspepsia without other evident reasons. Keywords: Gastroparesis, gastric emptying, diabetes, scintigraphy Address for Correspondence: Majid Assadi MD, Bushehr University of Medical Sciences, The Persian Gulf Nuclear Medicine Research Center, Bushehr, Iran Phone: +098-771-2580169 E-mail: assadipoya@yahoo.com Received: 27.10.2016 Accepted: 13.02.2017 Amac: Gastroparezi gecikmis mide bosalmasi olarak tammlanir ve diyabetik hastalarda sik rastlanan bir tibbi durumdur. Gastroparezinin kantitatif degerlendirmesi icin sintigrafi siklikla Standart bir diagnostik yontem olarak kullanilmaktadir. Bu calismanin amaclari gastroparezi tanisinda optimum goruntuleme zamanini belirlemek, gastroparezi prevalansini belirlemek, endoskopi ve sintigrafi bulgulan arasindaki uyumu ve mide bosalmasi ile cinsiyet, kan glukoz duzeyi ve fonksiyonel dispepsi arasmdaki iliskiyi incelemektir. Yontem: Ortalama yaslari 50,16 olan 50 diyabetik hastanin mide bosalmasi degerlendirildi. Mide bosalmasini degerlendirmek icin her hastaya 2 dilim tost, 120 cc isaretlenmemis su ve 1 mCi [.sup.99m]Tc ile isaretlenmis kizartilmis yumurtadan olusan bir ogun verildi. Oral alimin hemen sonrasinda 1., 1,5., 2. ve 4. saatlerde sintigrafi yapildi. Bazi hastalarda ek olarak 90. dakika dinamik goruntulemesi de uygulandi. Bulgular: calisma grubunda gastroparezi prevalansi %64 olarak bulundu. Ayni zamanda oral alimdan sonra 4. saat goruntulemesinin gecikmis mide bosalmasmin degerlendirilmesinde 90. dakika dinamik goruntulemeden daha uygun oldugu bulundu. Birinci saat ve 2. saat, 1. saat ve 90. dakika, 2. saat ve 90. dakika, 2. saat ve 4. saat goruntulemeleri arasinda istatistiksel olarak anlamli fark yoktu. Benzer sekilde, tum gruplarda kan glukoz duzeyi, cinsiyet ve hesaplanan mide bosalma zamani arasmda anlamli bir iliski saptanmadi. Goruntulemeler arasinda cinsiyet, kan sekeri duzeyi ve mide bosalma sureleri acisindan da fark tespit edilmedi. Sonuc: Sonuclarimiza gore gastroparezi prevalansinin daha once bildirilenden daha yuksek oldugu one surulebilir. Benzer sekilde, bu calisma gida alimmdan 2 ve 4 saat sonra uygulanan mide bosalma sintigrafisinin dispeptik sikayetleri olan ancak diger bariz nedenler bulunmayan diyabetik hastalarda gerekli klinik bilgiyi verebilecegini ongormektedir. Anahtar kelimeler: Gastroparezi, mide bosalmasi, diyabet, sintigrafi

Source Citation

Source Citation   

Gale Document Number: GALE|A532597648