Effect of Helicobacter pylori Infection on Duodenitis in Patients with Dyspepsia/Dispepsisi Olan Hastalarda Helicobacter pylori Enfeksiyonunun Duodenit Uzerine Etkisi

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From: European Journal of Therapeutics(Vol. 24, Issue 1)
Publisher: AVES
Document Type: Report
Length: 3,087 words
Lexile Measure: 1220L

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Abstract :

Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role in duodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection on clinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia. Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study. The control group was formed from H. pylori-negative dyspepsia patients (n=60). Clinical, biochemical, and endoscopical evaluations were performed on all subjects. Biopsies were obtained from the gastric antrum, corpus, and duodenal bulb to detect H. pylori and for histopathological assessments. Results: H. pylori infection was positive in 71 patients (54.2%). We detected ulcer-like dyspepsia in 87 patients (66.4%) and dysmotility-like dyspepsia in 44 patients (33.6%). There were no marked differences in biochemical parameters between the groups. On the other hand, there was a marked decrease in ferritin levels in H. pylori-positive group (p=0.001). Endoscopical examination showed that the H. pylori-positive group had more frequent erosive duodenitis (p=0.039). Villous obliteration and duodenal intraepithelial lymphocytosis as histopathological features were seen more commonly in the H. pylori-positive group (p Conclusion: Our data demonsrated that the presence of gastric H. pylori infection is one of the components that can influence the endoscopical, histopathological and laboratory features of duodenitis. Keywords: Duodenitis, Helicobacter pylori, dyspepsia, endoscopy, histopathology Amaç: Helicobacter pylori (H. pylori) infeksiyonu, birçok gastroduodenal hastaligin baslica nedenlerinden biridir, fakat duodenit olusumundaki rolü tam olarak bilinmemektedir. Bu çalismanin amaci, dispepsili hastalarda duodenitin klinik, laboratuar ve endoskopik özellikleri üzerine gastrik H. pyloriinfeksiyonunun rolünü arastirmakti. Yöntemler: Bu çalismaya toplamda 131 hasta (77 kadin ve 54 erkek) dahil edildi. Kontrol grubu H. pylori-negatif dispepsi hastalarindan olusturuldu (n=60). Bütün hastalarda klinik, biyokimyasal ve endoskopik degerlendirmeler yapildi. H. pylori'yi saptamak ve histopatolojik degerlendirmeler için gastrik antrum, korpus ve duodenal bulbusdan biyopsiler alindi. Bulgular: H. pylori infeksiyonu 71 hastada pozitifti (%5w4,2). Ülser benzeri dispepsiyi 87 hastada (%66,4) ve dismotilite benzeri dispepsiyi 44 hastada tespit ettik (%33,6). Gruplar arasinda biyokimyasal parametrelerde anlamli farkliliklar yoktu. Fakat, H. pylori-pozitif grupta ferritin düzeylerinde anlamli azalma vardi (p=0,001). Endoskopik muayenede H. pylori-pozitif grupta daha sik erozif duodenit gözlendi (p=0,039). H. pylori-pozitif grupta histopatolojik özellik olarak villus obliterasyonu ve duodenal intraepiteliyal lenfositoz daha çok gözlendi (her iki grup için p Sonuç: Sonuçlarimiz gastrik H. pylori infeksiyonunun varliginin duodenitin endoskopik, histopatolojik ve laboratuar özelliklerini etkileyebilen unsurlardan biri oldugunu gösterdi. Anahtar kelimeler: Duodenit, Helicobacter pylori, dispepsi, endoskopi, histopatoloji

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Gale Document Number: GALE|A559893330