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    Academic Journals

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• Next-Generation Sequencing Somatic and Germline Assay Troubleshooting Guide Derived From Proficiency Testing Data.

  Authors:Valentina Nardi, Karen D. Tsuchiya, Annette S. Kim, Lora J.H. Bean, Jaimie G. Halley, Thomas A. Long, et al.From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20225,569 words Report 1480LContext.--Next-generation sequencing-based assays are increasingly used in clinical molecular laboratories to detect somatic variants in solid tumors and hematologic malignancies and to detect constitutional variants....

• Limited Adenocarcinoma of the Prostate on Needle Core Biopsy: Is Accurate Grading Critical?

  Authors:Phoenix D. Bell, Yuki Teramoto, Pratik M.S. Gurung, Zhiming Yang, and Hiroshi MiyamotoFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20224,279 words Report 1840LContext.--Grading small foci of prostate cancer on a needle biopsy is often difficult, yet the clinical significance of accurate grading remains uncertain. Objective.--To assess if grading of limited adenocarcinoma on...

• From HIV to Coronavirus Disease 2019 (COVID-19): Hematologic Complications in Viral Pandemics.

  Author:Donald S. KarcherFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20225,410 words Report 2110LContext.--From the onset of the human immunodeficiency virus (HIV) pandemic in the 1980s to the recent coronavirus disease 2019 (COVID-19) pandemic, multiple viral pandemics have occurred and all have been associated...

• Assessment of Clonotypic Rearrangements and Minimal Residual Disease in Lymphoid Malignancies: A Large Cancer Center Experience Using clonoSEQ.

  Authors:Mohammad O. Hussaini, Jaya Srivastava, Lik Wee Lee, Taiga Nishihori, Bijal D. Shah, Melissa Alsina, et al.From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20226,742 words Report 1640LContext.--Measurable (minimal) residual disease (MRD) is an independent prognostic factor for survival outcomes in patients with lymphoid and plasma cell malignancies and has been incorporated into consensus criteria...

• Measuring the Efficacy of Pathology Career Recruitment Strategies in US Medical Students.

  Authors:Patricia V. Hernandez, Dana Razzano, Nicole D. Riddle, John T. Fallon, Humayun K. Islam, Kamran M. Mirza, et al.From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20223,710 words Report 2070LContext.--Multiple articles and surveys in the literature suggest that medical students find a career in pathology undesirable and believe it is disproportionately focused primarily on the autopsy. Objective.--To...

• Home Antigen Test Recall Affects Millions: Beware False Positives, but Also Uncertainty and Potential False Negatives.

  Author:Gerald J. KostFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 2022902 words Letter to the editor 1550LTo the Editor.--On November 10, 2021, the US Food and Drug Administration (FDA) announced a class I recall, "Potential for false positive results with certain lots of Ellume coronavirus disease-19 (COVID-19) home tests...

• Hemophagocytic Lymphohistiocytosis.

  Authors:Tanya Sajan Ponnatt, Cullen M. Lilley, and Kamran M. MirzaFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20229,973 words Disease/Disorder ove... 1850LContext.--Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of immune regulation that can eventually result in end-organ damage and death. HLH is characterized by uncontrolled activation of...

• Evolution of COVID-19 Testing and the Role of Rapid Antigen Testing in a Molecular-Focused World.

  Authors:Nam K. Tran and Larissa MayFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20222,309 words Editorial 2310LThe COVID-19 pandemic resulted in a significant expansion of infectious diseases testing technology. (1) As of November 2021, the US Food and Drug Administration (FDA) has conferred emergency use authorization (EUA) to...

• Advancing Fellowship Training in Selective Pathology: Design and Implementation of the Milestones 2.0.

  Authors:Ian S. Hagemann, Robin Elliott, Alexandra Kalof, Elaine S. Keung, Ninad Patil, and Jo Elle G. PetersonFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20223,615 words Report 1570LContext.--Program requirements for Selective Pathology fellowships in the United States were established by the Accreditation Council for Graduate Medical Education (ACGME) in 2011 to govern fellowships providing...

• Validating Whole Slide Imaging Systems for Diagnostic Purposes in Pathology: Guideline Update From the College of American Pathologists in Collaboration With the American Society for Clinical Pathology and the Association for Pathology Informatics.

  Authors:Andrew J. Evans, Richard W. Brown, Marilyn M. Bui, Elizabeth A. Chlipala, Christina Lacchetti, Danny A. Milner, Jr., et al.From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20228,858 words Report 1560LContext.--The original guideline, "Validating Whole Slide Imaging for Diagnostic Purposes in Pathology," was published in 2013 and included 12 guideline statements. The College of American Pathologists convened an expert...

• [CD30.sup.+] Lymphoproliferative Disorders as Potential Candidates for CD30-Targeted Therapies.

  Authors:Roland Schwarting, Eric Behling, Ashleigh Allen, Vivian Arguello-Guerra, and Tulin Budak-AlpdoganFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 202214,581 words Report 1560LContext.--In the early 1980s, a monoclonal antibody termed Ki-1 was developed against a cell line derived from a patient with Hodgkin lymphoma. This antibody detected a limited number of benign activated lymphocytes in...

• The 21-Gene Recurrence Score in Special Histologic Subtypes of Breast Cancer: A Population-Based Study.

  Authors:H. Evin Gulbahce, Erinn Downs-Kelly, Kimberly A. Herget, and Gregory J. StoddardFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20223,706 words Report 1780LContext.--Recurrence score (RS) testing was developed and validated in invasive ductal and rare lobular carcinomas, although it is used for all special types of breast cancers. Objective.--To determine association of...

• Role of Flow Cytometric Immunophenotyping for Classic Hodgkin Lymphoma in Small Biopsy and Cytology Specimens.

  Authors:Alexander Chan, Jose Victor Scarpa Carniello, Qi Gao, Allison Sigler, Jeeyeon Baik, Mikhail Roshal, et al.From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20224,964 words Report 1740LContext.--The diagnosis of classic Hodgkin lymphoma (CHL) traditionally requires surgical tissue biopsy because of the paucity of diagnostic Hodgkin and Reed-Sternberg cells. Diagnosis can be challenging in small core...

• Lymphoproliferative Neoplasms With Plasmablastic Morphology: An Overview and Diagnostic Approach.

  Authors:Jiehao Zhou and Mehdi NassiriFrom:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 4) Peer-Reviewed

  Apr. 20225,929 words Medical condition ov... 1550LContext.--Plasmablastic morphology can be seen in several uncommon lymphoproliferative neoplasms. Sometimes it is difficult to distinguish these neoplasms from each other. Objective.--To review the current...