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    Academic Journals

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• Development and Comparison of In-house Line Probe Assay (LiPA) and SVBR Green Real-time PCR Regarding the Detection of Periodontal Pathogens

  Authors:Mohammad Soleimani and Mohammad Reza ZolfaghariFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20194,245 words Report 1450LBackground: Periodontal disease, which con become a chronic condition, is an inflammatory disease that upsets the soft and hard structures supporting the teeth. The aim of the present study was to design and develop an...

• Triploidy and Routine Combined First Trimester Pregnancy Screening

  Authors:Mitra Eftekhariyazdi, Ali Khaligh, Behnaz Suizi, Maryam Naghibi Nasab, and Davood Zare-AbdollahiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20191,883 words Report 1630LBackground: This report is about a pregnancy with a triploid fetus and underscores the potential of first trimester combined screening to detect this devastating chromosomal aberration earlier in pregnancy. This report...

• Preconditioning with SDF-1 Improves Therapeutic Outcomes of Bone marrow-derived Mesenchymal Stromal Cells in a Mouse Model of STZ-induced Diabetes

  Authors:Mohammad Sadegh Gholami Farashah, Parichehr Pasbakhsh, Ameneh Omidi, Saied Nekoonam, Roya Aryanpour, and Iraj Regardi KashaniFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20194,367 words Report 1450LBackground: Nowadays, transplantation of Bone marrow-derived Mesenchymal Stromal Cells (BMSCs) Is currently an important alternative therapy for patient's type 1 diabetes mellitus. But a number of critical obstacles lie...

• Development of One-Step Tetra-primer ARMS-PCR for Simultaneous Detection of the Angiotensin Converting Enzyme (ACE) I/D and rs4343Gene Polymorphisms and the Correlation with CAD Patients

  Authors:Mohammad Mehdi Heidari, Mehdi Hadadzadeh, and Hossein FallahzadehFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20192,438 words Report 1490LBackground: The Angiotensin Converting Enzyme (ACE) Insertion/Deletion and rs-4343 gene polymorphisms could be associated with pathogenesis of essential hypertension and cardiovascular disorders and Coronary Artery...

• Characterization of Monoclonal and Polyclonal Antibodies Recognizing Prostate Specific Antigen: Implication for Design of a Sandwich ELISA

  Authors:Sahar Raoofi Mohseni, Forough Golsaz-Shirazi, Mostafa Hosseini, Jalal Khoshnoodi, Tannaz Bahadori, Mohammad Ali Judaki, et al.From:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20194,426 words Report 1390LBackground: Prostate cancer is the second most common cancer in men. Prostate-Specific Antigen (PSA) is a tumor-associated glycoprotein with enzymatic activity which is secreted by the prostate gland. Following entry to...

• Prediction of RNA- and DNA-Binding Proteins Using Various Machine Learning Classifiers

  Authors:Mehdi Poursheikhali Asghari and Parviz AbdolmalekiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20194,356 words Report 1300LBackground: Nucleic acid-binding proteins play major roles in different biological processes, such as transcription, splicing and translation. Therefore, the nucleic acid-binding function prediction of proteins is a...

• Statistical Optimization of Process Parameters by Central Composite Design (CCD) for an Enhanced Production of L-asparaginase by Myroides gitamensis BSH-3, a Novel Species

  Authors:V.S.S.L. Prasad Talluri, Sri Santhi Lanka, and V. Rajagopal SaladiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20194,034 words Report 1430LBackground: The present study focused on the production of L-asparaginase using Solid State Fermentation (SSF) by Myroides gitamensis. Methods: Initially, five significant parameters (Carbon source; Nitrogen source,...

• Recovery of MicroRNA from Stored Bone Marrow Aspirate Slides

  Authors:Elaheh Sadat Ghodousi and Soheila RahgozarFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20192,277 words Report 1530LBackground: Archived bone marrow aspirate slides are almost infinite, readily available resource of biospecimens that enable retrospective molecular investigations of diseases. RNAs obtained from slides has limitations...

• Identification of Potential Lead Molecules for Zika Envelope Protein from In Silico Perspective

  Authors:Selvaa Kumar Chellasamy and Shine DevarajanFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20193,869 words Report 1340LBackground: Zika virus is the family member of flavivirus with no reported clinically approved drugs or vacdnes in the market till date. This virus is spread by Aedes mosquitoes, and can also be transmitted through...

• A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq

  Authors:Chemmugil P., Lakshmi P.T.V., and Annamalai A.From:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20196,010 words Report 1690LBackground: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. Methods: In this study, the Indian medicinal...

• Monoclonal Antibody a Promising Treatment for Depression

  Author:Shahin AkhondzadehFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 2019913 words Editorial 1470LMajor depressive disorder (MDD) is one of the prominent causes of disability in the world, affecting 15-20% of people over the period of a lifetime. Patients commonly experience continuous remaining symptoms, functional...

• The Association of PON1 192 Q/R Polymorphism with the Risk of Idiopathic Male Infertility in Northern Iran

  Authors:Setareh Behrouzi, Farhad Mashayekhi, and Mohammad Hadi BahadoriFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 201971 words Brief article, Corre... 2020LThe Editorial Board of Avicenna Journal of Medical Biotechnology (AJMB) has decided to retract the original article entitled "The Association of PON1 192 Q/R Polymorphism with the Risk of Idiopathic Male Infertility in...

• Expression and Activity of Platelet Endothelial Nitric Oxide Synthase Are Decreased in Patients with Coronary Thrombosis and Stenosis

  Authors:Zahra Emami, Alireza Mesbah Namin, Javad Kojuri, Farideh Mashayekhi Jalali, and Mozhgan RastiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20193,941 words Report 1430LBackground: Nitric Oxide (NO) which is synthesized by endothelial Nitric Oxide Synthase (eNOS) in both vascular tissues and platelets plays an important role as a protective mediator in the cardiovascular system. It...

• Evaluation of Differential Gene Expression during Transdifferentiation of Bone Marrow Stromal Cells to Glial Phenotype in the Presence of Cerebrospinal Fluid

  Authors:Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi, Nourollah Rezaei, and Sara SoleimaniFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20193,902 words Report 1310LBackground: The present study assessed the alteration of gene expression during transdifferentiation of Bone Marrow Stromal Cells (BMSCs) into oligodendrocyte in the presence of Cerebrospinal Fluid (CSF). Methods:...

• The Effect of TAX-1 Gene of Human T-cell Leukemia Virus Type-1 on the Expression of CCR5 in K562 Cell Line

  Authors:Nasrin Haghnazari Sadaghiani, Lila Pirayeshfard, Afsaneh Aghaie, and Zohreh SharifiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20193,040 words Report 1430LBackground: Tax-1 protein of Human T-cell Leukemia Virus type 1(HTLV-1) serves as a bey transcriptional regulatory gene product and has a crucial role in transactivating genes of infected cells by employing their...

• Enhancing Stability of Destabilized Green Fluorescent Protein Using Chimeric mRNA Containing Human Beta-Globin 5' and 3' Untranslated Regions

  Authors:Setare Adibzadeh, Majid Fardaei, Mohammad A.N. Takhshid, Mohammad Reza Miri, Gholamreza Rafiei Dehbidi, A.N. Farhadi, et al.From:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20193,428 words Report 1530LBackground: In spite of recent progress in mRNA technologies and their potential applications for treatment of human diseases, problems such as the transient nature of mRNA limit the stability of gene up-regulation and,...

• The Anti-cancer Effects of Capparis spinosa Hydroalcoholic Extract

  Authors:Ysaman Moghadamnia, Seydeh Narges Mousavi Kani, Maryam Ghasemi-Kasman, Mohamad Taghi Kazemi Kani, and Sohrab KazemiFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 20192,903 words Report 1450LBackground: Recently, due to the steep increase in cancer lethality statistics, pharmaceutical societies seek approaches for designing drugs with higher efficiency and lower expenses. Plant-based drugs have therefore...

• Antibody-Drug Conjugates: Possibilities and Challenges

  Authors:Mohammad-Reza Nejadmoghaddam, Arash Minai-Tehrani, Ramin Ghahremanzadeh, Morteza Mahmoudi, Rassoul Dinarvand, and Amir-Hassan ZarnaniFrom:Avicenna Journal of Medical Biotechnology (Vol. 11, Issue 1) Peer-Reviewed

  January-March 201911,604 words Report 1530LThe design of Antibody Drug Conjugates (ADCs) as efficient targeting agents for tumor cell is still in its infancy for clinical applications. This approach incorporates the antibody specificity and cell billing activity...