Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Jan 05, 2022) And Volume Number (227) - Results

Select Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression.

1

Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression.

Authors:Yingmei Lu, Yiyue Feng, Zhao Li, Junfang Li, Honghua Zhang, Xiaoling Hu, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022369 words Report, Brief articl...

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Select Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

2

Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

Authors:Hongrui Lei, Zhi Cao, Huinan Wu, Tong Li, Xinyu Wang, Yuxiang Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022361 words Report, Brief articl...

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Select An efficient strategy for digging protein-protein interactions for rational drug design - A case study with HIF-1[alpha]/VHL.

3

An efficient strategy for digging protein-protein interactions for rational drug design - A case study with HIF-1[alpha]/VHL.

Authors:Xin Xue, Ji-Bo Kang, Xiao Yang, Nan Li, Liang Chang, Juan Ji, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022426 words Article

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Select Coumarin--benzimidazole hybrids: A review of developments in medicinal chemistry.

4

Coumarin--benzimidazole hybrids: A review of developments in medicinal chemistry.

Authors:Arya C. G, Ramesh Gondru, Yupeng Li, and Janardhan BanothuFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022330 words Report, Brief articl...

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Select Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/[alpha]-synuclein aggregation inhibitors with neuroprotective effects.

5

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/[alpha]-synuclein aggregation inhibitors with neuroprotective effects.

Authors:Yasmeen T. AlNajjar, Moustafa Gabr, Ahmed K. ElHady, Mohamed Salah, Gerrit Wilms, Ashraf H. Abadi, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022446 words Report

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Select NO-HDAC dual inhibitors.

6

NO-HDAC dual inhibitors.

Authors:Negar Omidkhah and Razieh GhodsiFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022295 words Report, Brief articl...

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Select Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.

7

Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.

Authors:Yiyue Feng, Yingmei Lu, Junfang Li, Honghua Zhang, Zhao Li, Hanzhong Feng, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022409 words Report

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Select Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents.

8

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents.

Authors:Wenbo Yin, Hengxian Cui, Hong Jiang, Yuxin Zhang, Lei Liu, Tianxiao Wu, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022319 words Report, Brief articl...

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Select Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.

9

Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.

Authors:Kangjia Sheng, Yiming Song, Fan Lei, Wanqing Zhao, Liming Fan, Lei Wu, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022295 words Report, Brief articl...

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Select Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR.

10

Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR.

Authors:Jun Yan, Yuzhu Xu, Xing Jin, Qiaoxuan Zhang, Feng Ouyang, Liqiao Han, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022399 words Report, Brief articl...

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Select P2Y.sub.12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies.

11

P2Y.sub.12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies.

Authors:Belal O. Al-Najjar, Fadi G. Saqallah, Manal A. Abbas, Serena Z. Al-Hijazeen, and Obada A. SibaiFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022414 words Report

Abstract Only

Select Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.

12

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.

Authors:Vijay K. Nuthakki, Ramesh Mudududdla, and Sandip B. BharateFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022379 words Report, Brief articl...

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Select Mononucleoside phosphorodithiolates as mononucleotide prodrugs.

13

Mononucleoside phosphorodithiolates as mononucleotide prodrugs.

Authors:Nathalie Schlienger, Isabelle Lefebvre, Anne-Marie Aubertin, Suzanne Peyrottes, and Christian PérigaudFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022265 words Report, Brief articl...

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Select Research progress of azido-containing Pt(IV) antitumor compounds.

14

Research progress of azido-containing Pt(IV) antitumor compounds.

Authors:Meilin Mu, Jiuyu Zhan, Xiaohan Dai, and Hongwei GaoFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022216 words Report, Brief articl...

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Select Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.

15

Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.

Authors:Yuka Miyazaki, Masaki Kikuchi, Koji Umezawa, Aurelie Descamps, Daichi Nakamura, Gaku Furuie, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022490 words Report

Abstract Only

Select Acridine--O .sup.6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity.

16

Acridine--O .sup.6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity.

Authors:Jaime Franco Pinto, Alexandra Fillion, Patricia Duchambon, Sophie Bombard, and Anton GranzhanFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022512 words Report

Abstract Only

Select Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.

17

Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.

Authors:Qinlong Xu, Mengqi Hu, Jiaming Li, Xiaodong Ma, Zhaoxing Chu, Qihua Zhu, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022366 words Brief article

Abstract Only

Select Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

18

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

Authors:Rong Hu, Wan-Li Wang, Ying-Yue Yang, Xia-Tong Hu, Qi-Wei Wang, Wei-Qiong Zuo, et al.From:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022352 words Report, Brief articl...

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Select One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.

19

One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.

Authors:Reham F. Barghash, Wagdy M. Eldehna, Markéta Kovalová, Veronika Vojácková, Vladimír Krystof, and Hatem A. Abdel-AzizFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022396 words Report

Abstract Only

Select Synthesis and in vitro antitrypanosomal evaluation of novel 6-heteroarylidene-substituted quinolone derivatives.

20

Synthesis and in vitro antitrypanosomal evaluation of novel 6-heteroarylidene-substituted quinolone derivatives.

Authors:Klaudia T. Angula, Lesetja J. Legoabe, Tarryn Swart, Heinrich C. Hoppe, and Richard M. BeteckFrom:European Journal of Medicinal Chemistry (Vol. 227) Peer-Reviewed

Jan. 5, 2022331 words Report, Brief articl...

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Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression.

Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

An efficient strategy for digging protein-protein interactions for rational drug design - A case study with HIF-1[alpha]/VHL.

Coumarin--benzimidazole hybrids: A review of developments in medicinal chemistry.

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/[alpha]-synuclein aggregation inhibitors with neuroprotective effects.

NO-HDAC dual inhibitors.

Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents.

Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.

Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR.

P2Y.sub.12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies.

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.

Mononucleoside phosphorodithiolates as mononucleotide prodrugs.

Research progress of azido-containing Pt(IV) antitumor compounds.

Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.

Acridine--O .sup.6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity.

Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.

Synthesis and in vitro antitrypanosomal evaluation of novel 6-heteroarylidene-substituted quinolone derivatives.

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