Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Jan 15, 2022) And Volume Number (228) - Results

Select The evolution paths of some reprehensive scaffolds of ROR[gamma]t modulators, a perspective from medicinal chemistry.

1

The evolution paths of some reprehensive scaffolds of ROR[gamma]t modulators, a perspective from medicinal chemistry.

Authors:Zhuohao Li, Tao Liu, Xixin He, and Chuan BaiFrom:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022291 words Report, Brief articl...

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Select Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.

2

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.

Authors:Peng Zhao, Linghang Zhuang, Xiangzhu Wang, Song Huang, Heping Wu, Yu Zhou, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022322 words Report, Brief articl...

Abstract Only

Select A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy.

3

A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy.

Authors:Sha-Sha Li, Cheng-Mei Zhang, Jing-De Wu, Chao Liu, and Zhao-Peng LiuFrom:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022334 words Report, Brief articl...

Abstract Only

Select Nitroxoline and its derivatives are potent inhibitors of metallo-[beta]-lactamases.

4

Nitroxoline and its derivatives are potent inhibitors of metallo-[beta]-lactamases.

Authors:Anna Proschak, Giada Martinelli, Denia Frank, Marco J. Rotter, Steffen Brunst, Lilia Weizel, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022289 words Report, Brief articl...

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Select 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.

5

2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.

Authors:Niccolò Chiaramonte, Andrea Angeli, Silvia Sgambellone, Alessandro Bonardi, Alessio Nocentini, Gianluca Bartolucci, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022401 words Report

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Select Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.

6

Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.

Authors:Stepan K. Krymov, Alexander M. Scherbakov, Diana I. Salnikova, Danila V. Sorokin, Lyubov G. Dezhenkova, Ivan V. Ivanov, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022350 words Report, Brief articl...

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Select Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.

7

Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.

Authors:Bao Cheng, Guirong Zhu, Linghua Meng, Guolin Wu, Qin Chen, and Shengming MaFrom:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022329 words Report, Brief articl...

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Select The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates.

8

The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates.

Authors:Yue Li, Yifan Ouyang, Han Wu, Peng Wang, Yu Huang, Xue Li, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022521 words Report

Abstract Only

Select Antitumor activity of novel POLA1-HDAC11 dual inhibitors.

9

Antitumor activity of novel POLA1-HDAC11 dual inhibitors.

Authors:Sabrina Dallavalle, Loana Musso, Raffaella Cincinelli, Nadine Darwiche, Silvia Gervasoni, Giulio Vistoli, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022442 words Report

Abstract Only

Select Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids.

10

Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids.

Authors:Xuemei Deng, Tian Luo, Zhao Li, Huaixiu Wen, Honghua Zhang, Xiaoyan Yang, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022343 words Report, Brief articl...

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Select Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus.

11

Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus.

Authors:Yonghua Liu, Jianrui Li, Yuxi Gu, Ling Ma, Shan Cen, Zonggen Peng, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022237 words Report, Brief articl...

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Select Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies.

12

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies.

Authors:Jing Guo, Shuang Xiang, Jie Wang, Yang Zhou, Zuqin Wang, Zhang Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022304 words Report, Brief articl...

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Select Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.

13

Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.

Authors:Ziyi Liang, Fang Lei, Jiedan Deng, Honghua Zhang, Yuqing Wang, Junfang Li, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022329 words Report, Brief articl...

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Select Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.

14

Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.

Authors:A. Dassonville-Klimpt, J. Schneider, C. Damiani, C. Tisnerat, A. Cohen, N. Azas, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022384 words Report

Abstract Only

Select Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.

15

Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.

Authors:Wenxia Liu, Zhuang Sun, Yunfei An, Yating Liu, Haiyan Fan, Jun Han, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022353 words Report, Brief articl...

Abstract Only

Select Synthesis, biological, and structural explorations of a series of [mu]-opioid receptor (MOR) agonists with high G protein signaling bias.

16

Synthesis, biological, and structural explorations of a series of [mu]-opioid receptor (MOR) agonists with high G protein signaling bias.

Authors:Yifei Yang, Yonghai Wang, Aixia Zuo, Chunmei Li, Wenyan Wang, Wanglin Jiang, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022473 words Report

Abstract Only

Select Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

17

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Authors:Kai Yuan, Wenbin Kuang, Weijiao Chen, Minghui Ji, Wenjian Min, Yasheng Zhu, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022314 words Report, Brief articl...

Abstract Only

Select Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.

18

Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.

Authors:Xiaoan Li, Tiantian Guo, Qian Feng, Tiantian Bai, Lei Wu, Yubo Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022379 words Report, Brief articl...

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Select Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

19

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

Authors:Jinxin Che, Canliang Ma, Jialiang Lu, Binhui Chen, Qiuqiu Shi, Xinxin Jin, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022397 words Report, Brief articl...

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Select Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents.

20

Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents.

Authors:Francisco J. Hicke, Adrián Puerta, Jelena Dinic, Milica Pesic, José M. Padrón, Óscar López, et al.From:European Journal of Medicinal Chemistry (Vol. 228) Peer-Reviewed

Jan. 15, 2022497 words Report

Abstract Only

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The evolution paths of some reprehensive scaffolds of ROR[gamma]t modulators, a perspective from medicinal chemistry.

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.

A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy.

Nitroxoline and its derivatives are potent inhibitors of metallo-[beta]-lactamases.

2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.

Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.

Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.

The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates.

Antitumor activity of novel POLA1-HDAC11 dual inhibitors.

Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids.

Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus.

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies.

Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.

Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.

Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.

Synthesis, biological, and structural explorations of a series of [mu]-opioid receptor (MOR) agonists with high G protein signaling bias.

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents.

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