Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Feb 15, 2022) And Volume Number (230) - Results

Select Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.

1

Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.

Authors:Kunlong Li, Siqiang Chen, Xiaoyan Pang, Jian Cai, Xinya Zhang, Yonghong Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022517 words Report

Abstract Only

Select Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.

2

Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.

Authors:Lu Zhang, Jinying Tian, Hanzeng Cheng, Yajun Yang, Ying Yang, Fei Ye, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022341 words Report, Brief articl...

Abstract Only

Select Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis.

3

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis.

Authors:Shengtian Cao, Xinye Yang, Zheng Zhang, Junwen Wu, Bo Chi, Hong Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022333 words Report, Brief articl...

Abstract Only

Select Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption.

4

Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption.

Authors:Renshuai Zhang, Wenjing Liu, Jun Zeng, Jingsen Meng, Hongfei Jiang, Jie Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022252 words Report, Brief articl...

Abstract Only

Select A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

5

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

Authors:Martyn Frederickson, Irwin R. Selvam, Dimitrios Evangelopoulos, Kirsty J. McLean, Mona M. Katariya, Richard B. Tunnicliffe, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022539 words Report

Abstract Only

Select Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.

6

Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.

Authors:Xinyue Hu, Jifa Zhang, Ya Zhang, Fulun Jiao, Jiaxing Wang, Hao Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022415 words Report

Abstract Only

Select Tumor-microenvironmental-response Bi-functional molecules for efficient imaging and anti-tumor activity therapy.

7

Tumor-microenvironmental-response Bi-functional molecules for efficient imaging and anti-tumor activity therapy.

Authors:Jin Wang, Ru Si, Qingqing Zhang, Xiaoyan Pan, and Jie ZhangFrom:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022280 words Report, Brief articl...

Abstract Only

Select Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.

8

Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.

Authors:Léopold Thabault, Chiara Brustenga, Perrine Savoyen, Mégane Van Gysel, Johan Wouters, Pierre Sonveaux, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022423 words Report

Abstract Only

Select Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

9

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

Authors:Maria Dichiara, Antonia Artacho-Cordón, Rita Turnaturi, Miriam Santos-Caballero, Rafael González-Cano, Lorella Pasquinucci, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022334 words Report, Brief articl...

Abstract Only

Select Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy.

10

Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy.

Authors:Pengfei Xu and Raoling GeFrom:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022238 words Report, Brief articl...

Abstract Only

Select Multivalent peptide dendrimers inhibit the fusion of viral-cellular membranes and the cellular NF-[kappa]B signaling pathway.

11

Multivalent peptide dendrimers inhibit the fusion of viral-cellular membranes and the cellular NF-[kappa]B signaling pathway.

Authors:Xi Xie and Jian HeFrom:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022330 words Report, Brief articl...

Abstract Only

Select Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma.

12

Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma.

Authors:Jiaqi Lu, Ru Li, Binsong Mu, Yao Peng, Yi Zhao, Yuesen Shi, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022355 words Report, Brief articl...

Abstract Only

Select Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998--2021).

13

Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998--2021).

Authors:Youquan Xie, Yucheng Tian, Yuming Zhang, Zhisheng Zhang, Rui Chen, Mian Li, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022247 words Report, Brief articl...

Abstract Only

Select Synthesis and biological application of glyco- and peptide derivatives of fullerene C.sub.60.

14

Synthesis and biological application of glyco- and peptide derivatives of fullerene C.sub.60.

Authors:Lisa Tanzi, Marco Terreni, and Yongmin ZhangFrom:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022418 words Report

Abstract Only

Select Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.

15

Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.

Authors:Xiao Wang, Hongda Qiu, Na Yang, Haoji Xie, Weida Liang, Jiayu Lin, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022549 words Report

Abstract Only

Select Novel PHD2/HDACs hybrid inhibitors protect against cisplatin-induced acute kidney injury.

16

Novel PHD2/HDACs hybrid inhibitors protect against cisplatin-induced acute kidney injury.

Authors:Huiqiang Wei, Wenfeng Gou, Jun Gao, Hongxin Ning, Yang Song, Deguan Li, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022364 words Report, Brief articl...

Abstract Only

Select Synthesis of 8-aminomorphans with high KOR affinity.

17

Synthesis of 8-aminomorphans with high KOR affinity.

Authors:Hendrik Jonas, Daniele Aiello, Dirk Schepmann, Patrizia Diana, and Bernhard WünschFrom:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022272 words Report, Brief articl...

Abstract Only

Select Discovery of small-molecule fluorescent probes for C-Met.

18

Discovery of small-molecule fluorescent probes for C-Met.

Authors:Dong Liang, Chen Yu, Xiaojun Qin, Xingye Yang, Xuhui Dong, Mingzhao Hu, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022272 words Report, Brief articl...

Abstract Only

Select Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia.

19

Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia.

Authors:Jimin Hwang, Natalie Strange, Rami Mazraani, Matthew J. Phillips, Allan B. Gamble, Wilhelmina M. Huston, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022355 words Report, Brief articl...

Abstract Only

Select Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents.

20

Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents.

Authors:Xin Huang, Yu-Shuang Wang, Duo Ma, Yuan-Yuan Wang, Shi-Da Bian, Bo Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 230) Peer-Reviewed

Feb. 15, 2022442 words Report

Abstract Only

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Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.

Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis.

Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption.

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.

Tumor-microenvironmental-response Bi-functional molecules for efficient imaging and anti-tumor activity therapy.

Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy.

Multivalent peptide dendrimers inhibit the fusion of viral-cellular membranes and the cellular NF-[kappa]B signaling pathway.

Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma.

Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998--2021).

Synthesis and biological application of glyco- and peptide derivatives of fullerene C.sub.60.

Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.

Novel PHD2/HDACs hybrid inhibitors protect against cisplatin-induced acute kidney injury.

Synthesis of 8-aminomorphans with high KOR affinity.

Discovery of small-molecule fluorescent probes for C-Met.

Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia.

Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents.

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