Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Apr 05, 2022) And Volume Number (233) - Results

Select Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

1

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Authors:Wei Shi, Ping Zhang, Feng Zou, Jiaqi Zhou, Ziyu Yin, Zilong Cai, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022333 words Report, Brief articl...

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Select Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer.

2

Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer.

Authors:Mingyuan Li, Shuangshuang Li, Yuan Li, Xinyi Li, Guang Yang, Meng Li, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022373 words Report, Brief articl...

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Select Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library.

3

Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library.

Authors:Qi Liang, Haiyue Zuo, Tian Yang, Jiatai Yin, Xiaomin Huang, Jing Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022353 words Report, Brief articl...

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Select Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.

4

Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.

Authors:Marialuigia Fantacuzzi, Rosa Amoroso, Simone Carradori, and Barbara De FilippisFrom:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022287 words Report, Brief articl...

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Select Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo.

5

Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo.

Authors:Jianqing Zhang, Jintian Dai, Xin Lan, Ying Zhao, Feiyi Yang, Han Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022377 words Report, Brief articl...

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Select Discovery of polypyridyl iridium(III) complexes as potent agents against resistant Candida albicans.

6

Discovery of polypyridyl iridium(III) complexes as potent agents against resistant Candida albicans.

Authors:Chen Fu, Qian Lv, Jing Fan, Shiming Wu, Ming Lei, Xing Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022289 words Report, Brief articl...

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Select Recent development of BTK-based dual inhibitors in the treatment of cancers.

7

Recent development of BTK-based dual inhibitors in the treatment of cancers.

Authors:Fansheng Ran, Yun Liu, Zhongyuan Xu, Chi Meng, Dezhi Yang, Jianqiang Qian, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022379 words Report, Brief articl...

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Select Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents.

8

Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents.

Authors:Hu Wu, Chuanbiao Du, Yajie Xu, Lige Liu, Xin Zhou, and Qinggang JiFrom:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022329 words Report, Brief articl...

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Select Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents.

9

Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents.

Authors:Qimeng Yang, Feng Zhou, Xuelin Tang, Jialing Wang, Hui Feng, Wen Jiang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022397 words Report, Brief articl...

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Select Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors.

10

Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors.

Authors:Qidong Tang, Ting Peng, Jie Hu, Tao Zhang, Pengqin Chen, Daoxing Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022367 words Report, Brief articl...

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Select Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

11

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Authors:Yu Cao, Yutong Tu, Liping Fu, Qian Yu, Lixin Gao, Mengmeng Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022426 words Report

Abstract Only

Select Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy.

12

Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy.

Authors:Wenbo Yin, Lei Liu, Hong Jiang, Tianxiao Wu, Hengxian Cui, Yuxin Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022286 words Report, Brief articl...

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Select Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.

13

Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.

Authors:Xi Xu, Di Zhang, Tengteng Zhao, Min Wang, Yu Li, Qianming Du, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022326 words Report, Brief articl...

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Select Discovery of (S)--N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.

14

Discovery of (S)--N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.

Authors:Yue Qiao, Yang Zhang, Zhenrui Qiao, Wenya He, Yingda Chen, Depu Song, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022398 words Report, Brief articl...

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Select Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.

15

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.

Authors:Dexiang Hua and Xiaoxing WuFrom:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022178 words Report, Brief articl...

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Select Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs.

16

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs.

Authors:Jelena Popovic-Djordjevic, Cristina Quispe, Roberta Giordo, Aleksandar Kostic, Jelena S. Katanic Stankovic, Patrick Valere Tsouh Fokou, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022568 words Report

Abstract Only

Select A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives.

17

A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives.

Authors:Aihong Yang, Chang Liu, Hongwei Zhang, Jianhua Wu, Rui Shen, and Xiaodi KouFrom:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022367 words Report, Brief articl...

Abstract Only

Select Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C.

18

Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C.

Authors:Mei Zhu, Huiyu Zhou, Ling Ma, Biao Dong, Jiwei Ding, Jinming Zhou, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022347 words Report, Brief articl...

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Select pH-programmed responsive nanoplatform for synergistic cancer therapy based on single atom catalysts.

19

pH-programmed responsive nanoplatform for synergistic cancer therapy based on single atom catalysts.

Authors:Mei Yao, Wenxiu Han, Lu Feng, Zizhen Wei, Yong Liu, Huairong Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022352 words Report, Brief articl...

Abstract Only

Select Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.

20

Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.

Authors:Agnieszka Zagórska, Adam Bucki, Anna Partyka, Magdalena Jastrzebska-Wiesek, Agata Siwek, Monika Gluch-Lutwin, et al.From:European Journal of Medicinal Chemistry (Vol. 233) Peer-Reviewed

Apr. 5, 2022362 words Brief article

Abstract Only

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Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer.

Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library.

Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.

Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo.

Discovery of polypyridyl iridium(III) complexes as potent agents against resistant Candida albicans.

Recent development of BTK-based dual inhibitors in the treatment of cancers.

Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents.

Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents.

Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors.

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy.

Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.

Discovery of (S)--N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs.

A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives.

Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C.

pH-programmed responsive nanoplatform for synergistic cancer therapy based on single atom catalysts.

Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.

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