Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Apr 15, 2022) And Volume Number (234) - Results

Select Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.

1

Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.

Authors:Karanvir Singh, Piyush Kumar, Rohit Bhatia, Vipasha Mehta, Bhupinder Kumar, and Md Jawaid AkhtarFrom:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022436 words Report

Abstract Only

Select Virtual screening and crystallographic studies reveal an unexpected [gamma]-lactone derivative active against MptpB as a potential antitubercular agent.

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Virtual screening and crystallographic studies reveal an unexpected [gamma]-lactone derivative active against MptpB as a potential antitubercular agent.

Authors:Giulia Cazzaniga, Matteo Mori, Fiorella Meneghetti, Laurent R. Chiarelli, Giovanni Stelitano, Isabella Caligiuri, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022347 words Report, Brief articl...

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Select Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

3

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Authors:Yao Feng, Bing Zhang, Jialun Lv, Peng Zhang, Qing Mao, Fengwei Lin, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022361 words Report, Brief articl...

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Select Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.

4

Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.

Authors:Xiaona Sun, Yujin Wang, Zhichao Lei, Shasha Yue, Li Chen, and Jianbo SunFrom:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022295 words Report, Brief articl...

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Select From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.

5

From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.

Authors:Anze Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022361 words Report, Brief articl...

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Select Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells.

6

Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells.

Authors:Yong Wang, Pascal Pigeon, Wei Li, Jiangkun Yan, Patrick M. Dansette, Mohamed Othman, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022393 words Report, Brief articl...

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Select Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues.

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Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues.

Authors:Zhipeng Zhou, Linlin Zhang, Xin Wu, Lan Luo, Jian Wu, Dan Xu, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022337 words Report, Brief articl...

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Select Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors.

8

Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors.

Authors:Guanglei Nan, Lei Huang, Yunxuan Li, Yajun Yang, Ying Yang, Ke Li, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022383 words Report, Brief articl...

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Select Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus.

9

Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus.

Authors:Mohamed M. Elsebaie, Hanzada T. Nour El-Din, Nader S. Abutaleb, Abdelrahman A. Abuelkhir, Hsin-Wen Liang, Ahmed S. Attia, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022467 words Report

Abstract Only

Select Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

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Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

Authors:Patrik Zeyen, Yanira Zeyn, Daniel Herp, Fereshteh Mahmoudi, Talha Z. Yesiloglu, Frank Erdmann, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022553 words Report

Abstract Only

Select Drug repositioning: Progress and challenges in drug discovery for various diseases.

11

Drug repositioning: Progress and challenges in drug discovery for various diseases.

Authors:Yi Hua, Xiaowen Dai, Yuan Xu, Guomeng Xing, Haichun Liu, Tao Lu, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022333 words Report, Brief articl...

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Select Examination of the impact molecular charge has on NTSR1-targeted agents incorporated with cysteine protease inhibitors.

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Examination of the impact molecular charge has on NTSR1-targeted agents incorporated with cysteine protease inhibitors.

Authors:Wei Fan, Wenting Zhang, Sameer Alshehri, and Jered C. GarrisonFrom:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022454 words Article

Abstract Only

Select An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.

13

An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.

Authors:Wei Yang, Qianqian Feng, Zhiyun Peng, and Guangcheng WangFrom:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022342 words Report, Brief articl...

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Select Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.

14

Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.

Authors:Baijayantimala Swain, Santosh Kumar Sahoo, Priti Singh, Andrea Angeli, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022388 words Report, Brief articl...

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Select Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT.sub.2A receptor antagonists/inverse agonists.

15

Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT.sub.2A receptor antagonists/inverse agonists.

Authors:Mingxu Ma, Yifei Yang, Guangying Du, Yusen Dai, Xiaoyin Zhu, Wenyan Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022390 words Report, Brief articl...

Abstract Only

Select Recent applications of vinyl sulfone motif in drug design and discovery.

16

Recent applications of vinyl sulfone motif in drug design and discovery.

Authors:Reza Ahmadi and Saeed EmamiFrom:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022234 words Report, Brief articl...

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Select Design and development of photoswitchable DFG-Out RET kinase inhibitors.

17

Design and development of photoswitchable DFG-Out RET kinase inhibitors.

Authors:Yongjin Xu, Chunxia Gao, Måns Andreasson, Liliana Håversen, Marta P. Carrasco, Cassandra Fleming, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022451 words Report

Abstract Only

Select Discovery and evaluation of chalcone derivatives as novel potential anti-Toxoplasma gondii agents.

18

Discovery and evaluation of chalcone derivatives as novel potential anti-Toxoplasma gondii agents.

Authors:Liping Jiang, Bo Liu, Shengjie Hou, Tiande Su, Qiyun Fan, Eman Alyafeai, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022408 words Report

Abstract Only

Select Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents.

19

Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents.

Authors:Guoqiang Yao, Jianchen Yu, Cai Lin, Yujia Zhu, Anna Duan, Mengfeng Li, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022522 words Report

Abstract Only

Select Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.

20

Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.

Authors:Amalyn Nain-Perez, Anders Foller Füchtbauer, Liliana Håversen, Aleksei Lulla, Chunxia Gao, Josipa Matic, et al.From:European Journal of Medicinal Chemistry (Vol. 234) Peer-Reviewed

Apr. 15, 2022372 words Report, Brief articl...

Abstract Only

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Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.

Virtual screening and crystallographic studies reveal an unexpected [gamma]-lactone derivative active against MptpB as a potential antitubercular agent.

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.

From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.

Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells.

Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues.

Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors.

Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus.

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

Drug repositioning: Progress and challenges in drug discovery for various diseases.

Examination of the impact molecular charge has on NTSR1-targeted agents incorporated with cysteine protease inhibitors.

An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.

Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.

Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT.sub.2A receptor antagonists/inverse agonists.

Recent applications of vinyl sulfone motif in drug design and discovery.

Design and development of photoswitchable DFG-Out RET kinase inhibitors.

Discovery and evaluation of chalcone derivatives as novel potential anti-Toxoplasma gondii agents.

Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents.

Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.

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