Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (May 05, 2022) And Volume Number (235) - Results

Select Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.

1

Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.

Authors:Michela I. Simone, Adam Wood, David Campkin, Milton J. Kiefel, and Todd A. HoustonFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022201 words Report, Brief articl...

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Select Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells.

2

Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells.

Authors:Xiao-Fan Zhang, Ming-Zhu Luan, Wei-Bin Yan, Feng-Lan Zhao, Yun Hou, Gui-Ge Hou, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022322 words Report, Brief articl...

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Select Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

3

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

Authors:Giuseppe Campiani, Tuhina Khan, Cristina Ulivieri, Leopoldo Staiano, Chiara Papulino, Stefania Magnano, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022668 words Report

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Select Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.

4

Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.

Authors:Grant D. Walby and Stephen F. MartinFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022273 words Report, Brief articl...

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Select Tandem construction of biological relevant aliphatic 5-membered N-heterocycles.

5

Tandem construction of biological relevant aliphatic 5-membered N-heterocycles.

Authors:Daniel Lowicki and Piotr PrzybylskiFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022392 words Report, Brief articl...

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Select HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials.

6

HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials.

Authors:Hai Ye, Tian Lv, Tao Min, Di Mao, Xingran Chen, Boxiang Ding, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022337 words Brief article

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Select pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma.

7

pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma.

Authors:Yi Zhao, Yao Peng, Zhongzhen Yang, Jiaqi Lu, Ru Li, Yuesen Shi, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022376 words Report, Brief articl...

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Select New N-aryl-N'-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT.sub.1A receptor.

8

New N-aryl-N'-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT.sub.1A receptor.

Authors:Przemyslaw Zareba, Pawel Sliwa, Grzegorz Satala, Pawel Zajdel, Gniewomir Latacz, and Jolanta JaskowskaFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022344 words Report, Brief articl...

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Select Novel inhibitors of AChE and A[beta] aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.

9

Novel inhibitors of AChE and A[beta] aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.

Authors:Yulin Liu, Giuseppe Uras, Itse Onuwaje, Wenlong Li, Hong Yao, Shengtao Xu, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022430 words Report

Abstract Only

Select Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine.

10

Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine.

Authors:Max Van Hoof, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, and Steven De JongheFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022283 words Report, Brief articl...

Abstract Only

Select Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.

11

Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.

Author:Mehdi ValipourFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022263 words Report, Brief articl...

Abstract Only

Select Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective.

12

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective.

Authors:Yongsheng Zhang, Xinjie Liang, Xuefei Bao, Wei Xiao, and Guoliang ChenFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022326 words Report, Brief articl...

Abstract Only

Select Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.

13

Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.

Authors:Vincenzo Cilibrasi, Virginia Spanò, Roberta Bortolozzi, Marilia Barreca, Maria Valeria Raimondi, Roberta Rocca, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022484 words Report

Abstract Only

Select Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells.

14

Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells.

Authors:Bingxue Qu, Yongjin Xu, Yang Lu, Weihao Zhuang, Xinxin Jin, Qiuqiu Shi, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022377 words Report, Brief articl...

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Select Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.

15

Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.

Authors:Hui Zhong, Mingxuan Zhao, Chunyu Wu, Jiayao Zhang, Li Chen, and Jianbo SunFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022268 words Report, Brief articl...

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Select A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.

16

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.

Authors:Sabina Sblano, Carmen Cerchia, Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Rosalba Leuci, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022397 words Report, Brief articl...

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Select Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2.

17

Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2.

Authors:Yu-Pu Juang, Yu-Ting Chou, Ru-Xian Lin, Hsiu-Hua Ma, Tai-Ling Chao, Jia-Tsrong Jan, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022354 words Report, Brief articl...

Abstract Only

Select Amphiphilic cyclic peptide [W.sub.4KR.sub.5]-Antibiotics combinations as broad-spectrum antimicrobial agents.

18

Amphiphilic cyclic peptide [W.sub.4KR.sub.5]-Antibiotics combinations as broad-spectrum antimicrobial agents.

Authors:Eman H.M. Mohammed, Sandeep Lohan, Rakesh K. Tiwari, and Keykavous ParangFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022377 words Report, Brief articl...

Abstract Only

Select Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.

19

Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.

Authors:Teodor Dimitrov, Cetin Anli, Athina Anastasia Moschopoulou, Thales Kronenberger, Mark Kudolo, Christian Geibel, et al.From:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022430 words Report

Abstract Only

Select Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase.

20

Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase.

Authors:Jiangxin Liu, Jian Ren, Kun Yang, Shuang Chen, Xinni Yang, and Qin-Shi ZhaoFrom:European Journal of Medicinal Chemistry (Vol. 235) Peer-Reviewed

May 5, 2022271 words Report, Brief articl...

Abstract Only

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Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.

Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells.

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.

Tandem construction of biological relevant aliphatic 5-membered N-heterocycles.

HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials.

pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma.

New N-aryl-N'-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT.sub.1A receptor.

Novel inhibitors of AChE and A[beta] aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.

Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine.

Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective.

Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.

Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells.

Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.

Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2.

Amphiphilic cyclic peptide [W.sub.4KR.sub.5]-Antibiotics combinations as broad-spectrum antimicrobial agents.

Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.

Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase.

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