Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Jul 05, 2022) And Volume Number (237) - Results

Select Discovery of novel pleuromutilin derivatives as potent antibacterial agents.

1

Discovery of novel pleuromutilin derivatives as potent antibacterial agents.

Authors:Yuhang Zhou, Yunpeng Yi, Jiangkun Wang, Zheng Yang, Qinqin Liu, Wanxia Pu, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022341 words Report, Brief articl...

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Select Spiral molecules with antimalarial activities: A review.

2

Spiral molecules with antimalarial activities: A review.

Authors:Jing Yang, Yonggang Wang, Wen Guan, Weiwei Su, Gang Li, Suode Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022269 words Report, Brief articl...

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Select Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.

3

Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.

Authors:Olaia Martí-Marí, Belén Martínez-Gualda, Irene Fernández-Barahona, Alberto Mills, Rana Abdelnabi, Sam Noppen, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022336 words Report, Brief articl...

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Select New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.

4

New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.

Authors:Maria Dolores Moya-Garzon, Barbara Rodriguez-Rodriguez, Cristina Martin-Higueras, Francisco Franco-Montalban, Miguel X. Fernandes, Jose A. Gomez-Vidal, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022469 words Report

Abstract Only

Select Exploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents.

5

Exploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents.

Authors:Cai Lin, Izet Karalic, An Matheeussen, Pim-Bart Feijens, Fabian Hulpia, Louis Maes, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022339 words Brief article

Abstract Only

Select Conformational adjustment overcomes multiple drug-resistance mutants of tropomyosin receptor kinase.

6

Conformational adjustment overcomes multiple drug-resistance mutants of tropomyosin receptor kinase.

Authors:Long-Can Mei, Lin-Sheng Zhuo, Hong-Chuang Xu, Wei Huang, Ge-Fei Hao, and Guang-Fu YangFrom:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022266 words Report, Brief articl...

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Select Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.

7

Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.

Authors:Cheng Wang, Xin Wang, Zhi Huang, Tianqi Wang, Yongwei Nie, Shengyong Yang, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022290 words Report, Brief articl...

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Select Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells.

8

Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells.

Authors:Marilia Barreca, Angela Maria Ingarra, Maria Valeria Raimondi, Virginia Spanò, Michele De Franco, Luca Menilli, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022346 words Report, Brief articl...

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Select The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery.

9

The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery.

Authors:Teppo O. Leino, Peter Sieger, Jari Yli-Kauhaluoma, Erik A.A. Wallén, and Jörg T. KleyFrom:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022270 words Report, Brief articl...

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Select Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes.

10

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes.

Authors:Jiannan Zhao, Yongling Li, Jing Ma, Jingting Liu, Ruoxuan Xiao, Linlin Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022440 words Report

Abstract Only

Select Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation.

11

Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation.

Authors:Dorothy Semenya, Meir Touitou, Domiziana Masci, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Guilherme Felipe Dos Santos Fernandes, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022320 words Report, Brief articl...

Abstract Only

Select Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno[2,3-d]pyrimidine substitution.

12

Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno[2,3-d]pyrimidine substitution.

Authors:Rongcai Ding, Xiaoxia Wang, Jianfang Fu, Yaoyao Chang, Yingxue Li, Yajing Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022273 words Report, Brief articl...

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Select Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study.

13

Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study.

Authors:Yin Sun, Ruifeng Wang, Yu Sun, Lin Wang, Yanli Xue, Jingkai Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022380 words Report, Brief articl...

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Select Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway.

14

Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway.

Authors:Xin-yang Li, Xin-hua Qian, Ju Zhu, Yu-heng Li, Qi-qi Lin, Shuai Li, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022286 words Report, Brief articl...

Abstract Only

Select Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review.

15

Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review.

Authors:Yi-Han Chang and Hsin-Yi HungFrom:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022227 words Report, Brief articl...

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Select Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.

16

Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.

Authors:Sumi Lee, Dhulfiqar Ali Abed, Mai-Uyen Nguyen, Michael P. Verzi, and Longqin HuFrom:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022383 words Report, Brief articl...

Abstract Only

Select Discovery a series of quinazolin derivatives as potent AXL inhibitors.

17

Discovery a series of quinazolin derivatives as potent AXL inhibitors.

Authors:Lin-Lin Zhang, Jian Wu, Dong-Dong Li, Xiao-Jun Ji, Chang-You Ma, and Dan XuFrom:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022105 words Brief article

Abstract Only

Select Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.

18

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.

Authors:Leonardo Brunetti, Rosalba Leuci, Antonio Carrieri, Marco Catto, Sara Occhineri, Giuseppe Vinci, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022493 words Report

Abstract Only

Select Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy.

19

Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy.

Authors:Yizhu Xu, Huanhuan Wu, Lei Huang, Bingxin Zhai, Xiaofei Li, Shuaiqi Xu, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022429 words Report

Abstract Only

Select Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.

20

Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.

Authors:Jia-shu Chen, Mu-xuan Wang, Min-min Wang, Yu-kai Zhang, Xu Guo, Ying-ying Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 237) Peer-Reviewed

July 5, 2022585 words Report

Abstract Only

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Discovery of novel pleuromutilin derivatives as potent antibacterial agents.

Spiral molecules with antimalarial activities: A review.

Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.

New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.

Exploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents.

Conformational adjustment overcomes multiple drug-resistance mutants of tropomyosin receptor kinase.

Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.

Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells.

The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery.

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes.

Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation.

Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno[2,3-d]pyrimidine substitution.

Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study.

Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway.

Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review.

Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.

Discovery a series of quinazolin derivatives as potent AXL inhibitors.

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.

Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy.

Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.

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