Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Aug 05, 2022) And Volume Number (238) - Results

Select Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents.

1

Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents.

Authors:Goran Poje, Lais Pessanha de Carvalho, Jana Held, Diana Moita, Miguel Prudêncio, Ivana Perkovic, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022444 words Report

Abstract Only

Select Glycosylation increases the anti-QS as well as anti-biofilm and anti-adhesion ability of the cyclo (L-Trp-L-Ser) against Pseudomonas aeruginosa.

2

Glycosylation increases the anti-QS as well as anti-biofilm and anti-adhesion ability of the cyclo (L-Trp-L-Ser) against Pseudomonas aeruginosa.

Authors:Yinglu Wang, Lile Pan, Li Li, Ruipin Cao, Qian Zheng, Zuxian Xu, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022444 words Report

Abstract Only

Select The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.

3

The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.

Authors:You-lu Pan, Shen-xin Zeng, Rong-rong Hao, Mei-hao Liang, Zheng-rong Shen, and Wen-hai HuangFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022282 words Report, Brief articl...

Abstract Only

Select Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer.

4

Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer.

Authors:Sravani Pulya, Tarun Patel, Milan Paul, Nilanjan Adhikari, Suvankar Banerjee, Ganesh Routholla, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022457 words Report

Abstract Only

Select Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.

5

Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.

Authors:Yaxin Xiao, Jingjing Yang, Liangjing Zou, Pingzhou Wu, Wei Li, Yunzheng Yan, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022361 words Report, Brief articl...

Abstract Only

Select Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.

6

Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.

Authors:Hongjin Zhai, Chunying Luo, Pu Yang, Shuo Zhang, Huanhuan Wang, Yaquan Cao, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022295 words Report, Brief articl...

Abstract Only

Select Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.

7

Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.

Authors:Tianxiao Wu, Qiaohua Qin, Ruicheng Lv, Nian Liu, Wenbo Yin, Chenzhou Hao, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022271 words Report, Brief articl...

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Select Small molecules targeting cGAS-STING pathway for autoimmune disease.

8

Small molecules targeting cGAS-STING pathway for autoimmune disease.

Authors:Jiannan Zhao, Ruoxuan Xiao, Ruoqing Zeng, Ende He, and Ao ZhangFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022292 words Report, Brief articl...

Abstract Only

Select Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.

9

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.

Authors:Mostafa M. Elbadawi, Wagdy M. Eldehna, Alessio Nocentini, Warda R. Somaa, Sara T. Al-Rashood, Eslam B. Elkaeed, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022496 words Report

Abstract Only

Select Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer.

10

Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer.

Authors:Adrià Sánchez-Morales, Atilla Biçer, Vasilis Panagiotopoulos, Selma Crecente-Garcia, Cristina Benaiges, Sergi Bayod, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022428 words Report

Abstract Only

Select New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.

11

New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.

Authors:Sascha Jung, Natalie Fuchs, Christoph Grathwol, Ute A. Hellmich, Annika Wagner, Erika Diehl, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022372 words Report, Brief articl...

Abstract Only

Select Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.

12

Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.

Authors:Ya Zhang, Zelin Hu, Jifa Zhang, Changyu Ren, and Yuxi WangFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022440 words Report

Abstract Only

Select Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.

13

Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.

Authors:Yu Zhang, Hao Yang, Fang-Ting Wang, Xing Peng, Hai-Yang Liu, Qing-Jiang Li, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022325 words Report, Brief articl...

Abstract Only

Select Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

14

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

Authors:Xiaodong Dou, Qi Sun, Guofeng Xu, Yameng Liu, Caifang Zhang, Bingding Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022366 words Report, Brief articl...

Abstract Only

Select Identification, optimization, and biological evaluation of 3-O-[beta]-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein.

15

Identification, optimization, and biological evaluation of 3-O-[beta]-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein.

Authors:Hui Li, Chen Cheng, Shanshan Shi, Yan Wu, Yongfeng Gao, Zhihao Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022379 words Report, Brief articl...

Abstract Only

Select Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases.

16

Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases.

Authors:Limin Yang, Xin Ma, Kerong Guo, Jian Li, Chong Zhang, and Liqiang WuFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022266 words Report, Brief articl...

Abstract Only

Select Design, synthesis and antitumour activity of novel 5(6)-amino-benzimidazolequinones containing a fused morpholine.

17

Design, synthesis and antitumour activity of novel 5(6)-amino-benzimidazolequinones containing a fused morpholine.

Authors:Haixia Wang, Yao Meng, Jing Yang, Hao Huang, Yifan Zhao, Chuantao Zhu, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022318 words Report, Brief articl...

Abstract Only

Select Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015--2021).

18

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015--2021).

Authors:Patrik Oleksak, Eugenie Nepovimova, Zofia Chrienova, Kamil Musilek, Jiri Patocka, and Kamil KucaFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022319 words Report, Brief articl...

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Select Ring replacement recommender: Ring modifications for improving biological activity.

19

Ring replacement recommender: Ring modifications for improving biological activity.

Authors:Peter Ertl, Eva Altmann, Sophie Racine, and Richard LewisFrom:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022232 words Report, Brief articl...

Abstract Only

Select Identification of dihydroquinolizinone derivatives with cyclic ether moieties as new anti-HBV agents.

20

Identification of dihydroquinolizinone derivatives with cyclic ether moieties as new anti-HBV agents.

Authors:Xiaoyu Qin, Lu Yang, Xican Ma, Bin Jiang, Shuo Wu, Apeng Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 238) Peer-Reviewed

Aug. 5, 2022297 words Report, Brief articl...

Abstract Only

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Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents.

Glycosylation increases the anti-QS as well as anti-biofilm and anti-adhesion ability of the cyclo (L-Trp-L-Ser) against Pseudomonas aeruginosa.

The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.

Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer.

Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.

Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.

Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.

Small molecules targeting cGAS-STING pathway for autoimmune disease.

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.

Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer.

New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.

Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.

Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

Identification, optimization, and biological evaluation of 3-O-[beta]-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein.

Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases.

Design, synthesis and antitumour activity of novel 5(6)-amino-benzimidazolequinones containing a fused morpholine.

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015--2021).

Ring replacement recommender: Ring modifications for improving biological activity.

Identification of dihydroquinolizinone derivatives with cyclic ether moieties as new anti-HBV agents.

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