Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Sep 05, 2022) And Volume Number (239) - Results

Select A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships.

1

A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships.

Authors:Tanuja T. Yadav, Manikanta Murahari, G.J. Peters, and Mayur YCFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022429 words Report

Abstract Only

Select Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification.

2

Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification.

Authors:Ling Ma, Sujie Huang, Huan Xie, Panpan Ma, Bo Jia, Yufan Yao, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022396 words Report, Brief articl...

Abstract Only

Select Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule G[alpha]q/11 inhibitors against uveal melanoma.

3

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule G[alpha]q/11 inhibitors against uveal melanoma.

Authors:Jun-Jie Deng, Lu Liu, Yang Ge, Zhendong Song, Jie Huang, Guangjin Fan, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022296 words Report, Brief articl...

Abstract Only

Select Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria.

4

Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria.

Authors:Vigyasa Singh, Rahul Singh Hada, Ravi Jain, Manu Vashistha, Geeta Kumari, Snigdha Singh, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022455 words Report

Abstract Only

Select A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.

5

A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.

Authors:Qi Li, Baichen Xiong, Yuanyuan Wang, Weiping Lyu, Shuaishuai Xing, Ying Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022420 words Report

Abstract Only

Select Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.

6

Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.

Authors:Ziyi Liang, Yuqing Wang, Honghua Zhang, Jiedan Deng, Fang Lei, Junfang Li, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022386 words Report, Brief articl...

Abstract Only

Select Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.

7

Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.

Authors:Baohui Qi, Fei Wang, Huan He, Mengmeng Fan, Liping Hu, Li Xiong, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022375 words Report, Brief articl...

Abstract Only

Select Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.

8

Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.

Authors:Xiangyu Zhang, Yixiang Sun, Hailan Huang, Xinran Wang, Tianxiao Wu, Wenbo Yin, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022348 words Report, Brief articl...

Abstract Only

Select Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.

9

Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.

Authors:Jian-Fei Bai, Somi Reddy Majjigapu, Bernard Sordat, Sophie Poty, Pierre Vogel, Pilar Elías-Rodríguez, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022469 words Report

Abstract Only

Select Computational method for the systematic alignment of analogue series with structure-activity relationship transfer potential across different targets.

10

Computational method for the systematic alignment of analogue series with structure-activity relationship transfer potential across different targets.

Authors:Atsushi Yoshimori and Jürgen BajorathFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022283 words Report, Brief articl...

Abstract Only

Select Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

11

Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

Authors:Yaoliang Sun, Ying Zhang, Xiaoai Chen, Aisong Yu, Wenhao Du, Yuting Huang, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022461 words Report

Abstract Only

Select Design, synthesis, and structure--activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

12

Design, synthesis, and structure--activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

Authors:Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022309 words Report, Brief articl...

Abstract Only

Select Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against [alpha]-synuclein oligomers and fibrils.

13

Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against [alpha]-synuclein oligomers and fibrils.

Authors:Bing Jiang, Feng Han, Ming-Huan Lü, Zhen-Ping Wang, Wei Liu, Yun-Xiao Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022366 words Report, Brief articl...

Abstract Only

Select Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.

14

Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.

Authors:Karolína Vanková, Eva Dolezelová, Eva Tloustová, Dana Hocková, Alena Zíková, and Zlatko JanebaFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022268 words Report, Brief articl...

Abstract Only

Select Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.

15

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.

Authors:Joana Reis, Carlos Fernandes, Hoda Salem, Marta Maia, Cláudia Tomé, Sofia Benfeito, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022360 words Report, Brief articl...

Abstract Only

Select Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.

16

Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.

Author:Usman GhaniFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022438 words Article

Abstract Only

Select Design, synthesis and biological evaluation of biphenyl-benzamides as potent FtsZ inhibitors.

17

Design, synthesis and biological evaluation of biphenyl-benzamides as potent FtsZ inhibitors.

Authors:Jingjing Deng, Tao Zhang, Baiqing Li, Mingyuan Xu, and Yuanze WangFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022289 words Report, Brief articl...

Abstract Only

Select Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.

18

Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.

Authors:Pei Shen, Yezhi Wang, Xiangxiang Jia, Pengfei Xu, Lian Qin, Xi Feng, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022353 words Report, Brief articl...

Abstract Only

Select Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.

19

Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.

Authors:Kritika Engle and Gautam KumarFrom:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022357 words Report, Brief articl...

Abstract Only

Select Design and development of a novel series of oral bivalent BET inhibitors with potent anticancer activities.

20

Design and development of a novel series of oral bivalent BET inhibitors with potent anticancer activities.

Authors:Menglan Luo, Qian Wu, Yueyue Yang, Lin Sun, Xiajuan Huan, Changqing Tian, et al.From:European Journal of Medicinal Chemistry (Vol. 239) Peer-Reviewed

Sept. 5, 2022310 words Report, Brief articl...

Abstract Only

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A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships.

Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification.

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule G[alpha]q/11 inhibitors against uveal melanoma.

Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria.

A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.

Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.

Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.

Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.

Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.

Computational method for the systematic alignment of analogue series with structure-activity relationship transfer potential across different targets.

Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

Design, synthesis, and structure--activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against [alpha]-synuclein oligomers and fibrils.

Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.

Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.

Design, synthesis and biological evaluation of biphenyl-benzamides as potent FtsZ inhibitors.

Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.

Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.

Design and development of a novel series of oral bivalent BET inhibitors with potent anticancer activities.

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