Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Oct 05, 2022) And Volume Number (240) - Results

Select Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors.

1

Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors.

Authors:Michael Juchum, Bent Pfaffenrot, Philip Klövekorn, Roland Selig, Wolfgang Albrecht, Lars Zender, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022342 words Report, Brief articl...

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Select Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.

2

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.

Authors:Honghua Zhang, Yuying Wang, Yuqing Wang, Xuelin Li, Shuzhi Wang, and Zhen WangFrom:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022334 words Report, Brief articl...

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Select Complete regression of xenografted breast tumors by dextran-based dual drug conjugates containing paclitaxel and docosahexaenoic acid.

3

Complete regression of xenografted breast tumors by dextran-based dual drug conjugates containing paclitaxel and docosahexaenoic acid.

Authors:Shenxu Wang, Jiaojiao Liu, Hongshuai Lv, Xiaoyan Huang, Peng Dong, Qi Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022401 words Report, Brief articl...

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Select Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.

4

Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.

Authors:Li-Min Zhao, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Hu-Ri Piao, and Fen-Er ChenFrom:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022386 words Report, Brief articl...

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Select HIV nucleoside reverse transcriptase inhibitors.

5

HIV nucleoside reverse transcriptase inhibitors.

Authors:Franck Amblard, Dharmeshkumar Patel, Eleftherios Michailidis, Steven J. Coats, Mahesh Kasthuri, Nicolas Biteau, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022229 words Report, Brief articl...

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Select Current progress and novel strategies that target CDK12 for drug discovery.

6

Current progress and novel strategies that target CDK12 for drug discovery.

Authors:Peng Lei, Jifa Zhang, Peiyu Liao, Changyu Ren, Jiaxing Wang, and Yuxi WangFrom:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022395 words Report, Brief articl...

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Select Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors.

7

Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors.

Author:Mehdi ValipourFrom:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022354 words Report, Brief articl...

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Select Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

8

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

Authors:Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022570 words Report

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Select A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors.

9

A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors.

Authors:Jianshu Dong, Waqar Pervaiz, Bilal Tayyab, Dié Li, Lei Kang, Huimin Zhang, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022462 words Report

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Select A fragment-based drug discovery strategy applied to the identification of NDM-1 [beta]-lactamase inhibitors.

10

A fragment-based drug discovery strategy applied to the identification of NDM-1 [beta]-lactamase inhibitors.

Authors:Jérémy Caburet, Benjamin Boucherle, Sofiane Bourdillon, Giorgia Simoncelli, Federica Verdirosa, Jean-Denis Docquier, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022405 words Report

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Select Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules.

11

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules.

Authors:Nassima Oumata, Kui Lu, Yuou Teng, Christian Cavé, Yu Peng, Hervé Galons, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022456 words Report

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Select Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway.

12

Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway.

Authors:Jian Song, Sheng-Hui Wang, Chun-Hong Song, Wei-Xin Zhang, Jun-Xia Zhu, Xin-Yi Tian, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022470 words Report

Abstract Only

Select Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.

13

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.

Authors:Laura Di Magno, Antonio Coluccia, Marianna Bufano, Silvia Ripa, Giuseppe La Regina, Marianna Nalli, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022390 words Report, Brief articl...

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Select Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-[alpha] for different indications.

14

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-[alpha] for different indications.

Authors:Jessica Plescia, Damien Hédou, Maud Eva Pousse, Anne Labarre, Caroline Dufresne, Anthony Mittermaier, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022287 words Report, Brief articl...

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Select Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.

15

Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.

Authors:Qian Xie, Yanni Shen, Yanli Meng, Jianhui Liang, Jing Xu, Shishao Liang, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022305 words Report, Brief articl...

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Select The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.

16

The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.

Authors:Yan-Jing Shi, Jia Zhang, Yu-Wei Wang, Kang Ding, Yu Yan, Cong-Yuan Xia, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022269 words Report, Brief articl...

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Select Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer.

17

Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer.

Authors:Dong-Lin Yang, Ya-Jun Zhang, Jie Lei, Shi-Qiang Li, Liu-Jun He, Dian-Yong Tang, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022454 words Report

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Select Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022.

18

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022.

Authors:Giuseppe Floresta, Vincenzo Patamia, Chiara Zagni, and Antonio RescifinaFrom:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022235 words Report, Brief articl...

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Select Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents.

19

Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents.

Authors:Yinhu Wang, Ping Wu, Fangquan Liu, Junjie Chen, Jie Xue, Yinhui Qin, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022303 words Report, Brief articl...

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Select Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.

20

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.

Authors:Camille Hauguel, Sarah Ducellier, Olivier Provot, Nada Ibrahim, Diana Lamaa, Coline Balcerowiak, et al.From:European Journal of Medicinal Chemistry (Vol. 240) Peer-Reviewed

Oct. 5, 2022464 words Report

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Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors.

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.

Complete regression of xenografted breast tumors by dextran-based dual drug conjugates containing paclitaxel and docosahexaenoic acid.

Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.

HIV nucleoside reverse transcriptase inhibitors.

Current progress and novel strategies that target CDK12 for drug discovery.

Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors.

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors.

A fragment-based drug discovery strategy applied to the identification of NDM-1 [beta]-lactamase inhibitors.

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules.

Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway.

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-[alpha] for different indications.

Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.

The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.

Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer.

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022.

Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents.

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.

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