Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Nov 05, 2022) And Volume Number (241) - Results

Select Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors.

1

Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors.

Authors:Yanghan Liu, Bikash Debnath, Surinder Kumar, David B. Lombard, and Nouri NeamatiFrom:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022342 words Report, Brief articl...

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Select Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells.

2

Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells.

Authors:Nazariy Pokhodylo, Nataliya Finiuk, Olha Klyuchivska, Mykola A. Tupychak, Vasyl Matiychuk, Evgeny Goreshnik, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022376 words Report, Brief articl...

Abstract Only

Select Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance.

3

Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance.

Authors:Yi Gong, Feng-Xu Wu, Ming-Shu Wang, Hong-Chuang Xu, Lin-Sheng Zhuo, Guang-Fu Yang, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022315 words Brief article

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Select Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor.

4

Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor.

Authors:Zhijie Wang, Jiwei Ren, Kun Jia, Yuming Zhao, Li Liang, Zitian Cheng, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022479 words Report

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Select An overview on Estrogen receptors signaling and its ligands in breast cancer.

5

An overview on Estrogen receptors signaling and its ligands in breast cancer.

Authors:Muhammad Zafar Irshad Khan, Muhammad Uzair, Adila Nazli, and Jian-Zhong ChenFrom:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022266 words Report, Brief articl...

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Select Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors.

6

Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors.

Authors:Margarida Espadinha, Elizabeth A. Lopes, Vanda Marques, Joana D. Amaral, Daniel J.V.A. dos Santos, Mattia Mori, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022452 words Report

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Select Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors.

7

Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors.

Authors:Minjian Yang, Huimin Jiang, Zhuo Yang, Xue Liu, Hanyu Sun, Mengyao Hao, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022348 words Report, Brief articl...

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Select New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.

8

New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.

Authors:Milena Mlakic, Ilijana Odak, Ivan Faraho, Stanislava Talic, Martina Bosnar, Kornelija Lasic, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022338 words Report, Brief articl...

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Select A phthalocyanine-based photosensitizer for effectively combating triple negative breast cancer with enhanced photodynamic anticancer activity and immune response.

9

A phthalocyanine-based photosensitizer for effectively combating triple negative breast cancer with enhanced photodynamic anticancer activity and immune response.

Authors:Kunshan Huang, Meiqi Yan, Han Zhang, Jinping Xue, and Juanjuan ChenFrom:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022268 words Report, Brief articl...

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Select New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity.

10

New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity.

Authors:Mohamed A. Sabry, Mariam A. Ghaly, Azza R. Maarouf, and Hussein I. El-SubbaghFrom:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022356 words Report, Brief articl...

Abstract Only

Select Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity.

11

Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity.

Authors:Chen Chen, Hongrui Chu, Anyang Wang, Huanhuan Yin, Yanqiao Gao, Shuhua Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022376 words Report, Brief articl...

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Select New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

12

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

Authors:Tommaso Felicetti, Nicholas Cedraro, Andrea Astolfi, Giada Cernicchi, Gianmarco Mangiaterra, Salvatore Vaiasicca, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022460 words Report

Abstract Only

Select Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer.

13

Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer.

Authors:Xu Zheng, Xing Li, Liangliang Tian, Bin Wu, Jiawen Yu, Changyuan Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022341 words Report, Brief articl...

Abstract Only

Select Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

14

Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

Authors:Marília Lopes Monteiro, Dânya Bandeira Lima, Katielle Albuquerque Freire, Cibele Nicolaski Pedron, Emanuel Paula Magalhães, Brenna Pinheiro Silva, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022413 words Report

Abstract Only

Select Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay.

15

Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay.

Authors:Kun Zhang, Jingjing Liang, Ning Wang, Ning Li, Yurui Jiang, Xiaohe Li, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022338 words Report, Brief articl...

Abstract Only

Select Recent advances in combretastatin A-4 codrugs for cancer therapy.

16

Recent advances in combretastatin A-4 codrugs for cancer therapy.

Authors:Kerong Guo, Xin Ma, Jian Li, Chong Zhang, and Liqiang WuFrom:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022246 words Report, Brief articl...

Abstract Only

Select 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity.

17

4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity.

Authors:Cui Huo, Zongyuan Luo, Xiangli Ning, Xin Kang, Qin Yan, Yuying Guo, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022423 words Report

Abstract Only

Select Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

18

Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

Authors:Xiaohui Chen, Xuefeng Jin, Fengtao Huang, Juntao Wang, Xuefeng Cao, Peng George Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022345 words Report, Brief articl...

Abstract Only

Select Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.

19

Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.

Authors:Guorui Zhang, Ruijuan Yin, Xiufei Dai, Guanzhao Wu, Xin Qi, Rilei Yu, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022386 words Report, Brief articl...

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Select Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates.

20

Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates.

Authors:Jian-Xing Yang, Juan-Juan Li, Fang-Qian Yin, Guang-Yuan Wang, Wen-Tong Wei, Xiao-Liu Li, et al.From:European Journal of Medicinal Chemistry (Vol. 241) Peer-Reviewed

Nov. 5, 2022369 words Report, Brief articl...

Abstract Only

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Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors.

Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells.

Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance.

Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor.

An overview on Estrogen receptors signaling and its ligands in breast cancer.

Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors.

Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors.

New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.

A phthalocyanine-based photosensitizer for effectively combating triple negative breast cancer with enhanced photodynamic anticancer activity and immune response.

New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity.

Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity.

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer.

Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay.

Recent advances in combretastatin A-4 codrugs for cancer therapy.

4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity.

Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.

Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates.

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