Publication Title ("European Journal of Medicinal Chemistry") And Id (5MVQ) And Date (Dec 05, 2022) And Volume Number (243) - Results

Select Design, synthesis, and biological evaluation of Wee1 kinase degraders.

1

Design, synthesis, and biological evaluation of Wee1 kinase degraders.

Authors:Shulei Zhu, Jieyu Liu, Donghuai Xiao, Peipei Wang, Jingkun Ma, Xiaobei Hu, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022369 words Report, Brief articl...

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Select Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.

2

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.

Authors:Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolsak, Irena Zdovc, Tímea Imre, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022403 words Report

Abstract Only

Select A close look into the biological and synthetic aspects of fused pyrazole derivatives.

3

A close look into the biological and synthetic aspects of fused pyrazole derivatives.

Authors:Mei-Mei Li, Hui Huang, Yiru Pu, Wanrong Tian, Yun Deng, and Jun LuFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022255 words Brief article

Abstract Only

Select Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51.

4

Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51.

Authors:Hang Xu, Yan-hua Mou, Meng-bi Guo, Rui Zhang, Zhong-zuo Yan, Ran An, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022323 words Report, Brief articl...

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Select Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-[beta] plaques in Alzheimer's disease.

5

Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-[beta] plaques in Alzheimer's disease.

Authors:Nan Yue, Hualong Fu, Yimin Chen, Xi Gao, Jiapei Dai, and Mengchao CuiFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022299 words Report, Brief articl...

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Select The role of Platinum(IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022.

6

The role of Platinum(IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022.

Authors:Shihao Su, Yutong Chen, Pengfei Zhang, Ruijuan Ma, Wei Zhang, Jianing Liu, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022508 words Report

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Select Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

7

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

Authors:Valeria Napolitano, Piotr Mróz, Monika Marciniak, Vishal C. Kalel, Charlotte A. Softley, Julian D. Janna Olmos, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022487 words Report

Abstract Only

Select Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.

8

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.

Authors:Wesam Ali, Sabrina Garbo, Annamária Kincses, Márta Nové, Gabriella Spengler, Elisabetta Di Bello, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022633 words Report

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Select Recent progress toward developing axial chirality bioactive compounds.

9

Recent progress toward developing axial chirality bioactive compounds.

Authors:Zheyi Wang, Liying Meng, Xinxin Liu, Lingzi Zhang, Zongjiang Yu, and Guanzhao WuFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022245 words Report, Brief articl...

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Select S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy.

10

S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy.

Authors:Zhiqiang Xie, Liqing Lu, Zhenghua Wang, Qinhong Luo, Yuchen Yang, Tian Fang, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022380 words Report, Brief articl...

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Select Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

11

Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

Authors:Guoqing Lu, Wenxing Nie, Meixiu Xin, Yingfen Meng, Jiayi Gu, Hui Miao, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022425 words Report

Abstract Only

Select A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

12

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

Authors:Jinying Gu, Qiuyu Wu, Qiuyue Zhang, Qidong You, and Lei WangFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022307 words Brief article

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Select New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.

13

New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.

Authors:Angelica E. Graminha, Cecília Popolin, João Honorato de Araujo-Neto, Rodrigo S. Correa, Kátia M. de Oliveira, Luani R. Godoy, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022408 words Report

Abstract Only

Select Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5.

14

Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5.

Authors:Weiyi Qian, Guang-Feng Zhou, Xintong Ge, Jian-Xia Xue, Chang-Bo Zheng, Liu-Meng Yang, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022482 words Report

Abstract Only

Select Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors.

15

Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors.

Authors:Tao Yang, Yang Tian, Yingxue Yang, Minghai Tang, Mingsong Shi, Yong Chen, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022343 words Brief article

Abstract Only

Select Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.

16

Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.

Authors:Ramajayam Kuppusamy, Ying-Ting Hsu, Yi-Yu Ke, Po-Wei Chang, Yung-Chiao Chang, Hsiao-Fu Chang, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022369 words Report, Brief articl...

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Select Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors.

17

Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors.

Authors:Xiaofei Liang, Chun Wang, Beilei Wang, Juan Liu, Shuang Qi, Aoli Wang, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022371 words Report, Brief articl...

Abstract Only

Select Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives.

18

Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives.

Authors:Ya Zhang, Jifa Zhang, Jiaxing Wang, Hao Chen, Liang Ouyang, and Yuxi WangFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022446 words Report

Abstract Only

Select Hybrid molecules based on caffeic acid as potential therapeutics: A focused review.

19

Hybrid molecules based on caffeic acid as potential therapeutics: A focused review.

Authors:Xue Zhao, Ziwei Liu, Hao Liu, Ju Guo, and Sihui LongFrom:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022262 words Report, Brief articl...

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Select Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain [alpha]2C adrenergic receptors.

20

Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain [alpha]2C adrenergic receptors.

Authors:Santosh Alluri, Seth M. Eisenberg, Laurel A. Grisanti, Miles Tanner, Nora D. Volkow, Sung Won Kim, et al.From:European Journal of Medicinal Chemistry (Vol. 243) Peer-Reviewed

Dec. 5, 2022267 words Report, Brief articl...

Abstract Only

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Design, synthesis, and biological evaluation of Wee1 kinase degraders.

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.

A close look into the biological and synthetic aspects of fused pyrazole derivatives.

Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51.

Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-[beta] plaques in Alzheimer's disease.

The role of Platinum(IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022.

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.

Recent progress toward developing axial chirality bioactive compounds.

S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy.

Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.

Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5.

Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors.

Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.

Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors.

Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives.

Hybrid molecules based on caffeic acid as potential therapeutics: A focused review.

Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain [alpha]2C adrenergic receptors.

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