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    Academic Journals

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• Role of FSH and FSH receptor on HUVECs migration.

  Authors:Dailin Tan, Yongxu Zhao, Danjun Ma, and Fangfang TongFrom:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20213,587 words Report 1530LFollicle-stimulating hormone (FSH) is a pituitary glycoprotein that regulates follicle maturation through its binding to follicle-stimulating hormone receptor (FSHR). Endothelial cells express FSHR, but its exact role in...

• Detection of non-targeted transgenes by whole-genome resequencing for gene-doping control.

  Authors:Teruaki Tozaki, Aoi Ohnuma, Masaki Takasu, Kotono Nakamura, Mio Kikuchi, Taichiro Ishige, et al.From:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20214,563 words Report 1350LGene doping has raised concerns in human and equestrian sports and the horseracing industry. There are two possible types of gene doping in the sports and racing industry: (1) administration of a gene-doping substance to...

• Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice.

  Authors:Subrata Batabyal, Sivakumar Gajjeraman, Sanjay Pradhan, Sulagna Bhattacharya, Weldon Wright, and Samarendra MohantyFrom:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20219,247 words Report 1380LGene therapy-based treatment such as optogenetics offers a potentially powerful way to bypass damaged photoreceptors in retinal degenerative diseases and use the remaining retinal cells for functionalization to achieve...

• Liver targeting with rAAV7: balancing tropism with immune profiles.

  Author:Terence R. FlotteFrom:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 2021979 words Article 1640LAuthor(s): Terence R. Flotte 1 Author Affiliations: (1) University of Massachusetts Medical School, Worcester, USA The value of intravenous (IV) recombinant adeno-associated virus (rAAV) as a platform for delivery...

• Antitumor effects of IL-12 and GM-CSF co-expressed in an engineered oncolytic HSV-1.

  Authors:Kyoung-Ju Kim, Dahye Moon, So Jung Kong, Yu Seong Lee, Youngeun Yoo, Soyoung Kim, et al.From:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20217,906 words Report 1470LOncolytic viruses selectively replicate and destroy cancer cells while sparing normal cells, prompting their recognition as promising antitumor agents. Herpes simplex virus (HSV) is suitable as an anticancer agent, given...

• Self-amplifying RNA vaccines for infectious diseases.

  Authors:Kristie Bloom, Fiona van den Berg, and Patrick ArbuthnotFrom:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 202110,116 words Report 1530LVaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro...

• Reviewer recognition.

  From:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 2021812 words Article 1330LWe would like to thank all those listed below for taking the time to review for Gene Therapy in 2020--your generosity is much appreciated and we hope your association with the journal continues in the future. Author...

• Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model.

  Authors:Ling Wang, Aihua Bao, Ying Zheng, Aying Ma, Yi Wu, Huanxia Shang, et al.From:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20216,210 words Report 1350LRecent studies have revealed that YKL-40 is involved in the pathogenesis of asthma. However, its specific mechanism remains unclear. The present study aims to investigate the effect of adenovirus vector-mediated YKL-40...

• Therapeutic benefit after intracranial gene therapy delivered during the symptomatic stage in a feline model of Sandhoff disease.

  Authors:Victoria J. McCurdy, Aime K. Johnson, Heather L. Gray-Edwards, Ashley N. Randle, Allison M. Bradbury, Nancy E. Morrison, et al.From:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20219,949 words Report 1570LSandhoff disease (SD) is an autosomal recessive lysosomal storage disease caused by defects in the [beta]-subunit of [beta]-N-acetylhexosaminidase (Hex), the enzyme that catabolizes GM2 ganglioside. Hex deficiency causes...

• Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation.

  Authors:Fulya Erendor, Elif Ozgecan Sahin, Ahter D. Sanlioglu, Mustafa Kemal Balci, Thomas S. Griffith, and Salih SanliogluFrom:Gene Therapy (Vol. 28, Issue 3-4) Peer-Reviewed

  Apr. 20218,153 words Report 1540LType 1 diabetes (T1DM) is an autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas leading to hyperglycemia. Vasoactive intestinal peptide (VIP) manifests...