Search Results

• • 25 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

  Authors:Nan Jin, Bhumsuk Keam, Janice Cho, Michelle J. Lee, Hye Ryun Kim, Hayarpi Torosyan, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,105 words Report 1450LAlpelisib selectively inhibits the p110[alpha] catalytic subunit of PI3K[alpha] and is approved for treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck squamous cell carcinoma (HNSCC), 63%...

• Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.

  Authors:Wilian Correa-Macedo, Vinicius M. Fava, Marianna Orlova, Pauline Cassart, Ron Olivenstein, Joaquin Sanz, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20219,716 words Report 1420LPersons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV- associated TB is often the result of recent infection with Mycobacterium tuberculosis (M. tuberculosis) followed by rapid progression to...

• Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis.

  Authors:Nidhi S. Dey, Sujai Senaratne, Vijani Somaratne, Nayani P. Madarasinghe, Bimalka Seneviratne, Sarah Forrester, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20213,848 words Report 1280LCutaneous leishmaniasis (CL) is caused by Leishmania donovani in Sri Lanka. Pentavalent antimonials (e.g., sodium stibogluconate [SSG]) remain first-line drugs for CL with no new effective treatments emerging. We studied...

• Machine learning-driven identification of early-life air toxic combinations associated with childhood asthma outcomes.

  Authors:Yan-Chak Li, Hsiao-Hsien Leon Hsu, Yoojin Chun, Po-Hsiang Chiu, Zoe Arditi, Luz Claudio, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20218,019 words Report 1440LAir pollution is a well-known contributor to asthma. Air toxics are hazardous air pollutants that cause or may cause serious health effects. Although individual air toxics have been associated with asthma, only a limited...

• Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

  Authors:Taisuke Kato, Ri-Ichiroh Manabe, Hironaka Igarashi, Fuyuki Kametani, Sachiko Hirokawa, Yumi Sekine, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,286 words Report 1270LCerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of...

• RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11.

  Authors:Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202110,304 words Report 1410LFerroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation of evasion of ferroptosis during lung...

• Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease.

  Authors:Beste Mutlu and Pere PuigserverFrom:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20211,951 words Article 1350LCannabinoid receptor 1 (CB-1) antagonists are potential candidates for treating obesity and metabolic complications. Despite clear metabolic benefits, unwanted side effects in the brain pose issues for patients. With the...

• Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity.

  Authors:Qiwei Ge, Dingjiacheng Jia, Dong Cen, Yadong Qi, Chengyu Shi, Junhong Li, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,749 words Report 1280LEmerging evidence has shown that open reading frames inside long noncoding RNAs (lncRNAs) could encode micropeptides. However, their roles in cellular energy metabolism and tumor progression remain largely unknown. Here,...

• LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.

  Authors:Pavlos Missios, Edroaldo Lummertz da Rocha, Daniel S. Pearson, Julia Philipp, Maria M. Aleman, Mehdi Pirouz, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202110,668 words Report 1380LHigh expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing M/CN-amplified neuroblastoma as a model system, we showed that LIN28B expression was associated with enhanced cell...

• Recruiting a transcription factor in the liver to prevent Atherosclerosis.

  Author:Alan D. AttieFrom:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20211,791 words Article 1310LHypertriglyceridemia is associated with obesity, diabetes, and atherosclerosis. While lipoprotein lipase (LPL) hydrolyzes triglyceride (TG) cargo into remnant lipoproteins with atherogenic properties, how remnant...

• Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.

  Authors:Peter J. Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,144 words Report 1390LMetabolic pathways regulate immune responses and disrupted metabolism leads to immune dysfunction and disease. Coronavirus disease 2019 (COVID-19) is driven by imbalanced immune responses, yet the role of...

• Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

  Authors:Zhongyang Zhang, Zeguo Sun, Jia Fu, Qisheng Lin, Khadija Banu, Kinsuk Chauhan, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20219,759 words Report 1480LApolipoprotein L1 (APOL1) risk alleles in donor kidneys associate with graft loss, but whether recipient risk allele expression affects transplant outcomes is unclear. To test whether recipient APOL1 risk alleles...

• CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins.

  Authors:Masami Shimizu-Albergine, Debapriya Basu, Jenny E. Kanter, Farah Kramer, Vishal Kothari, Shelley Barnhart, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,878 words Report 1390LLoss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by augmenting the activity of lipoprotein...

• APOL1 risk variants in kidney transplantation: a modulation of immune cell function.

  Author:Andrew F. MaloneFrom:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20212,592 words Article 1310LAPOL1 G1 and G2 variants are established risk factors for nondiabetic kidney disease. The presence of two APOL1 risk variants in donor kidneys negatively impacts kidney allograft survival. Because of evolutionary...

• Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and Angiogenesis.

  Authors:Leeanna El- Houjeiri, Marco Biondini, Mathieu Paquette, Helen Kuasne, Alain Pacis, Morag Park, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,973 words Report 1430LGrowing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (FLCN) tumor suppressor complex...

• Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.

  Authors:Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20218,272 words Report 1390LThe endocannabinoid system regulates appetite and energy expenditure and inhibitors of cannabinoid receptor 1 (CB-1) induce weight loss with improvement in components of the metabolic syndrome. While CB-1 blockage in...

• Unlocking the complexity of HIV and Mycobacterium tuberculosis coinfection.

  Authors:Eileen P. Scully and Bryan D. BrysonFrom:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20212,236 words Article 1460LHIV and Mycobacterium tuberculosis (M. tuberculosis) coinfection increases the risk of active tuberculosis (aTB), but how HIV infection and medications contribute to drive risk remains unknown. In this issue of the JCI,...

• Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression.

  Authors:Ling Pan, Xudong Huang, Ze-Xian Liu, Ying Ye, Rui Li, Jialiang Zhang, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202111,073 words Report 1510LThe tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear, although chronic inflammation is implicated. Here, we identified an inflammatory cytokine-regulated transfer RNA- derived (tRNA-derived)...

• RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics.

  Authors:Raie T. Bekele, Amruta S. Samant, Amin H. Nassar, Jonathan So, Elizabeth P. Garcia, Catherine R. Curran, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20219,932 words Report 1450LBladder cancer is a genetically heterogeneous disease, and novel therapeutic strategies are needed to expand treatment options and improve clinical outcomes. Here, we identified a unique subset of urothelial tumors with...

• Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice.

  Authors:Marco Pirazzini, Alessandro Grinzato, Davide Corti, Sonia Barbieri, Oneda Leka, Francesca Vallese, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 202110,059 words Report 1410LWe used human monoclonal antibodies (humAbs) to study the mechanism of neuron intoxication by tetanus neurotoxin and to evaluate these antibodies as a safe preventive and therapeutic substitute for hyperimmune sera to...