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    Academic Journals

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• Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence.

  Authors:Alexander L. Greninger, Ksenia Rybkina, Michelle J. Lin, Jennifer Drew-Bear, Tara C. Marcink, Ryan C. Shean, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202110,362 words Report 1530LThe capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the host environment or drug treatment. Long-term infections in...

• Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation.

  Authors:Hatice Hasturk, George Hajishengallis, The Forsyth Institute Center for Clinical and Translational Research staff,, John D. Lambris, Dimitrios C. Mastellos, and Despina YancopoulouFrom:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20219,818 words Report 1520LBACKGROUND. Gingivitis and periodontitis are prevalent inflammatory diseases of the periodontal tissues. Current treatments are often ineffective or do not prevent disease recurrence. Uncontrolled complement activation...

• All our knowledge begins with the antisenses.

  Author:Ethan M. GoldbergFrom:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20212,768 words Viewpoint essay 1430LEpilepsy is the neurological disorder defined by spontaneous recurrent--seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the...

• Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.

  Authors:Cyril Djari, Isabelle Sahut-Barnola, Amandine Septier, Ingrid Plotton, Nathanaelle Montanier, Damien Dufour, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202111,783 words Report 1510LLarge-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple...

• Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model.

  Authors:Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Lisseth E. Burbano, Ben Rollo, Kay Richards, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20219,544 words Report 1350LDe novo variation in SCN2A can give rise to severe childhood disorders. Biophysical gain of function in SCN2A is seen in some patients with early seizure onset developmental and epileptic encephalopathy (DEE). In these...

• Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.

  Authors:Sita Awasthi, James J. Knox, Angela Desmond, Mohamad-Gabriel Alameh, Brian T. Gaudette, John M. Lubinski, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20219,462 words Report 1510LNucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent genital infection rather than an acute respiratory infection....

• Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex.

  Authors:Eduardo Fernandez, Arantxa Alfaro, Cristina Soto-Sanchez, Pablo Gonzalez-Lopez, Antonio M. Lozano, Sebastian Pena, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202111,685 words Report 1440LBACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical...

• Preexisting memory CD[4.sup.+] T cells contribute to the primary response in an HIV-1 vaccine trial.

  Authors:Suzanne L. Campion, Elena Brenna, Elaine Thomson, Will Fischer, Kristin Ladell, James E. McLaren, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20214,125 words Report 1400LNaive and memory CD[4.sup.+] T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD[4.sup.+] T cells to a primary immune...

• Raising the stakes for cortical visual prostheses.

  Authors:Michael S. Beauchamp, William H. Bosking, Denise Oswalt, and Daniel YoshorFrom:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20212,837 words Viewpoint essay 1490LIn this issue of the JCI, the dream of restoring useful vision to blind individuals with neurotechnology moves one step closer to realization. Fernandez et al. implanted an electrode array with 96 penetrating electrodes...

• MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.

  Authors:Pathricia Veronica Tilstam, Wibke Schulte, Thomas Holowka, Bong-Sung Kim, Jessica Nouws, Maor Sauler, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20219,645 words Report 1440LExcessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and...

• Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.

  Authors:Binita Chakraborty, Jovita Byemerwa, Jonathan Shepherd, Corinne N. Haines, Robert Baldi, Weida Gong, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202111,656 words Report 1530LImmune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been...

• T cell receptor-targeted immunotherapeutics drive selective in vivo HIV- and CMV-specific T cell expansion in humanized mice.

  Authors:Mengyan Li, Scott J. Garforth, Kaitlyn E. O'Connor, Hang Su, Danica M. Lee, Alev Celikgil, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202111,607 words Report 1700LTo delineate the in vivo role of different costimulatory signals in activating and expanding highly functional virus-specific cytotoxic [CD8.sup.+] T cells, we designed synTacs, infusible biologics that recapitulate...

• Will GWAS eventually allow the identification of genomic biomarkers for COVID-19 severity and mortality?

  Authors:Vito Luigi Colona, Michela Biancolella, Antonio Novelli, and Giuseppe NovelliFrom:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20212,248 words Report 1450LGWAS involve testing genetic variants across the genomes of many individuals to identify genotype-phenotype associations. GWAS have enabled the identification of numerous genomic biomarkers in various complex human...

• Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance.

  Authors:Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20217,900 words Report 1400LInsulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. A high rate of lipolysis is known to be associated with insulin...

• SGLT2 inhibitors: further evidence for heart failure with preserved ejection fraction as a metabolic disease?

  Authors:Justin B. Echouffo-Tcheugui, Sabra C. Lewsey, and Robert G. WeissFrom:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20212,230 words Viewpoint essay 1530LHeart failure with preserved ejection fraction: therapeutic challenges Heart failure (HF) affects 6 million American adults, over half of whom have HF with preserved ejection fraction (HFpEF; ref. 1). HFpEF is a...

• Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

  From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 202110,791 words Report 1440LBACKGROUND. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition. METHODS. We combined individual level data from 13,888 COVID-19...

• SARS-CoV-2 vaccine effectiveness in preventing confirmed infection in pregnant women.

  Authors:Adeel A. Bu, Hiam Chemaitelly, Abdullatif Al Khal, Peter V. Coyle, Huda Saleh, Anvar H. Kaleeckal, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 20213,859 words Report 1450LBACKGROUND. SARS-CoV-2 infection in pregnancy is associated with a higher risk of pregnancy-related complications and neonatal respiratory distress and hospitalization. Effectiveness of SARS-CoV-2 vaccines in pregnant...

• Corrigendum.

  From:Journal of Clinical Investigation (Vol. 131, Issue 23) Peer-Reviewed

  Dec. 1, 2021219 words Correction notice, B... 1070LMarton Keszei, Julien Record, Joanna S. Kritikou, Hannah Wurzer, Chiara Geyer, Meike Thiemann, Paul Drescher, Hanna Brauner, Laura Kocher, Jaime James, Minghui He, Marisa A.P. Baptista, Carin I.M. Dahlberg, Amlan Biswas,...