Search Results

• • 23 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.

  Authors:Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20228,042 words Report 1420LAltered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells...

• A molecular target of vascular calcification in chronic kidney disease.

  Author:Mohamed G. AttaFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20222,004 words Article 1360LVascular calcification (VC) causes cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD), particularly those with end-stage kidney disease (ESKD) on maintenance dialysis treatment. Although...

• Do endocannabinoids acting via hepatic CB-1 contribute to NAFLD and hepatic insulin resistance?

  Authors:George Kunos, Tony Jourdan, and Joseph TamFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 2022649 words Letter to the editor 1560LTo the Editor: The article by Wang et al. (1) challenges the concept, proposed and developed by us, that endocannabinoids acting via hepatic cannabinoid receptor 1 (CB-1) contribute to nonalcoholic fatty liver disease...

• Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.

  Authors:Nkiruka V. Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A. Walker, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202210,954 words Report 1270LChronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive....

• SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.

  Authors:Wenxin Li, Weijing Feng, Xiaoyan Su, Dongling Luo, Zhibing Li, Yongqiao Zhou, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20228,873 words Report 1210LVascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone...

• Addressing dyslipidemic risk beyond LDL-cholesterol.

  Authors:Alan R. Tall, David G. Thomas, Ainara G. Gonzalez-Cabodevilla, and Ira J. GoldbergFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20229,436 words Report 1400LDespite the success of LDL-lowering drugs in reducing cardiovascular disease (CVD), there remains a large burden of residual disease due in part to persistent dyslipidemia characterized by elevated levels of...

• Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction.

  Authors:Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20228,959 words Report 1420LAcute myocardial infarction (AMI) induces blood leukocytosis, which correlates inversely with patient survival. The molecular mechanisms leading to leukocytosis in the infarcted heart remain poorly understood. Using an...

• Corrigendum.

  From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202275 words Correction notice, B... 850LProgranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury Lauren Herl Martens, Jiasheng Zhang, Sami J. Barmada, Ping Zhou, Sherry Kamiya, Binggui Sun, Sang-Won Min, Li Gan,...

• The role of 15 lipoxygenase 1 in asthma comes into focus.

  Author:Joshua A. BoyceFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20222,902 words Report 1570LIL-4- and IL-13-driven epithelial cell expression of 15 lipoxygenase 1 (15LO1) is a consistent feature of eosinophil-dominated asthma known as type 2-high (T2-high) asthma. The abundant soluble products of arachidonic...

• Clinical development of metabolic inhibitors for oncology.

  Authors:Kathryn M. Lemberg, Sadakatali S. Gori, Takashi Tsukamoto, Rana Rais, and Barbara S. SlusherFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202211,281 words Report 1320LMetabolic inhibitors have been used in oncology for decades, dating back to antimetabolites developed in the 1940s. In the past 25 years, there has been increased recognition of metabolic derangements in tumor cells...

• Indoxyl sulfate in uremia: an old idea with updated concepts.

  Authors:Anders H. Berg, Sanjeev Kumar, and S. Ananth KarumanchiFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20221,857 words Report 1490LPatients with end-stage kidney disease (ESKD) have increased vascular disease. While protein-bound molecules that escape hemodialysis may contribute to uremic toxicity, specific contributing toxins remain ambiguous. In...

• Targeting memory T cell metabolism to improve immunity.

  Authors:Mauro Corrado and Erika L. PearceFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202210,116 words Report 1500LVaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens...

• Corrigendum.

  From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 2022142 words Correction notice, B... 1040LAtrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins Hui-Hua Li, Monte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass, and...

• Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection.

  Authors:Julie L. Mitchell, Justin Pollara, Kenneth Dietze, R. Whitney Edwards, Junsuke Nohara, Kombo F. N'guessan, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20228,737 words Report 1460LEarly initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased antigen load affects...

• Moving toward genome-editing therapies for cardiovascular diseases.

  Author:Kiran MusunuruFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20226,854 words Report 1590LThe rapid invention of genome-editing technologies over the past decade, which has already been transformative for biomedical research, has raised the tantalizing prospect of an entirely new therapeutic modality. Whereas...

• HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.

  Authors:Kanika Kanchan, Stepan Grinek, Henry T. Bahnson, Ingo Ruczinski, Gautam Shankar, David Larson, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202210,409 words Report 1540LWe investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an...

• Secreted acid sphingomyelinase as a potential gene therapy for limb girdle muscular dystrophy 2B.

  Authors:Daniel C. Bittel, Sen Chandra Sreetama, Goutam Chandra, Robin Ziegler, Kanneboyina Nagaraju, Jack H. Van der Meulen, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 202210,631 words Report 1490LEfficient sarcolemmal repair is required for muscle cell survival, with deficits in this process leading to muscle degeneration. Lack of the sarcolemmal protein dysferlin impairs sarcolemmal repair by reducing secretion...

• Does CB-1 in hepatic stellate cells contribute to liver fibrosis?

  Authors:Sophie Lotersztajn and Ariane MallatFrom:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 2022492 words Letter to the editor 1340LTo the Editor: The development of drugs targeting the peripheral cannabinoid receptor 1 (CB-1) has been identified as a major therapeutic opening for the management of nonalcoholic fatty liver disease (NAFLD) and liver...

• Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.

  Authors:Zongyi Li, Haoyun Duan, Yanni Jia, Can Zhao, Wenjing Li, Xin Wang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20227,531 words Report 1400LHuman pluripotent stem cells (hPSCs) hold great promise for the treatment of various human diseases. However, their therapeutic benefits and mechanisms for treating corneal endothelial dysfunction remain undefined. Here,...

• Kidney VISTA prevents IFN-[gamma]/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.

  Authors:Min-Gang Kim, Donghwan Yun, Chae Lin Kang, Minki Hong, Juhyeon Hwang, Kyung Chul Moon, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 1) Peer-Reviewed

  Jan. 1, 20228,386 words Report 1310LSevere glomerular injury ultimately leads to tubulointerstitial fibrosis that determines patient outcome, but the immunological molecules connecting these processes remain undetermined. The present study addressed...