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    Academic Journals

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• Clonal hematopoiesis in sickle cell disease.

  Authors:L. Alexander Liggett, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, S. Mehdi Nouraie, Mark T. Gladwin, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20225,403 words Report 1450LBACKGROUND. Curative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD...

• Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein.

  Authors:Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20226,218 words Report 1390LInfection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis...

• Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers.

  Authors:Katelyn L. Donahue and Marina Pasca di MaglianoFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20222,076 words Article 1470LA challenge in cancer treatment is targeting cancer cells while sparing normal cells. Thus, identifying cancer-specific neoepitopes is an active research area. Neoepitopes are generated by the accumulation of mutations;...

• IP3 receptor orchestrates maladaptive vascular responses in heart failure.

  Authors:Haikel Dridi, Gaetano Santulli, Jessica Gambardella, Stanislovas S. Jankauskas, Qi Yuan, Jingyi Yang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20228,221 words Report 1370LPatients with heart failure (HF) have augmented vascular tone, which increases cardiac workload, impairing ventricular output and promoting further myocardial dysfunction. The molecular mechanisms underlying the...

• A metabolic biomarker predicts Parkinson's disease at the early stages in patients and animal models.

  Authors:Da vid Mallet, Thibault Dufourd, Melina Decourt, Carole Carcenac, Paola Bossu, Laure Verlin, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 202211,803 words Report 1400LBACKGROUND. Care management of Parkinson's disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD...

• The fossilization of randomized clinical trials.

  Authors:Nigel S. Paneth, Michael J. Joyner, and Arturo CasadevallFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20222,530 words Article 1500LThe recognition, in the middle of the 20th century, that the randomized, controlled trial (RCT) was the preferred approach to determining the efficacy of medical interventions was revolutionary. Masking, placebos, and...

• Age-related GSK3[beta] overexpression drives podocyte senescence and glomerular aging.

  Authors:Yudong Fang, Bohan Chen, Zhangsuo Liu, Athena Y. Gong, William T. Gunning, Yan Ge, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 202211,236 words Report 1490LAs life expectancy continues to increase, clinicians are challenged by age-related renal impairment that involves podocyte senescence and glomerulosclerosis. There is now compelling evidence that lithium has a potent...

• GSK3[beta] and the aging kidney.

  Authors:Jordan A. Kreidberg and Valerie A. SchumacherFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20222,185 words Article 1400LKidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3p (GSK3[beta]) is involved with metabolism and may...

• Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.

  Authors:Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D. Tiwari, Dale R. Grabowski, Simona Pagliuca, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20229,841 words Report 1430LEltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem cell failure and pancytopenia, to improve...

• Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.

  Authors:Shion A. Lim, Jie Zhou, Alexander J. Martinko, Yung-Hua Wang, Ekaterina V. Filippova, Veronica Steri, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20229,910 words Report 1340LExtracellular proteolysis is frequently dysregulated in disease and can generate proteoforms with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that selectively recognize a proteolytic...

• [beta]-Catenin signaling in hepatocellular carcinoma.

  Authors:Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, and Xin ChenFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20228,297 words Report 1280LDeregulated Wnt/[beta]-catenin signaling is one of the main genetic alterations in human hepatocellular carcinoma (HCC). Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which...

• Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility.

  Authors:Tengfei Ma, Zhenbo Huang, Xueyi Xie, Yifeng Cheng, Xiaowen Zhuang, Matthew J. Childs, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 202210,525 words Report 1260LExposure to addictive substances impairs flexible decision making. Cognitive flexibility is mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking alters cognitive flexibility through...

• Colorectal cancer: the facts in the case of the microbiota.

  Authors:Slater L. Clay, Diogo Fonseca-Pereira, and Wendy S. GarrettFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20228,749 words Report 1430LThe importance of the microbiota in the development of colorectal cancer (CRC) is increasingly evident, but identifying specific microbial features that influence CRC initiation and progression remains a central task for...

• Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.

  Authors:Allison D. Oliva, Rupali Gupta, Khalil Issa, Ralph Abi Hachem, David W. Jang, Sebastian A. Wellford, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20228,606 words Report 1440LBACKGROUND. Presbyosmia, or aging-related olfactory loss, occurs in a majority of humans over age 65 years, yet remains poorly understood, with no specific treatment options. The olfactory epithelium (OE) is the...

• Remodeling of the tumor/tumor microenvironment ecosystem during KRAS G12C inhibitor clinical resistance in lung cancer.

  Authors:Tadashi Manabe and Trever G. BivonaFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20221,625 words Article 1570LKRAS G12C inhibitors such as sotorasib and adagrasib are often effective in KRAS G12C-driven non-small cell lung cancer (NSCLC) patients. However, acquired resistance limits long-term patient survival. In this issue of...

• TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.

  Authors:Haifeng Yin, Xiaoyun Guo, Yi Chen, Yachang Zeng, Xiaoliang Mo, Siqi Hong, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 202210,764 words Report 1380LMutations in TGF-[beta]-activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are...

• Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function.

  Authors:Typhanie Dumontet and Gary D. HammerFrom:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20222,275 words Article 1590LOsteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland-derived glucocorticoids inhibit osteocalcin production, which can ultimately cause...

• Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.

  Authors:Vivek D. Gandhi, Jacqueline-Yvonne Cephus, Allison E. Norlander, Nowrin U. Chowdhury, Jian Zhang, Zachary J. Ceneviva, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 202210,245 words Report 1440LWomen have higher prevalence of asthma compared with men. In asthma, allergic airway inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-13 production and eosinophil...

• Rapid idiosyncratic mechanisms of clinical resistance to KRAS G12C inhibition.

  Authors:Yihsuan S. Tsai, Mark G. Woodcock, Salma H. Azam, Leigh B. Thorne, Krishna L. Kanchi, Joel S. Parker, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20226,197 words Clinical report 1480LBACKGROUND. The KRAS proto-oncogene is among the most frequently mutated genes in cancer, yet for 40 years it remained an elusive therapeutic target. Recently, allosteric inhibitors that covalently bind to KRAS G12C...

• Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation.

  Authors:Jingjing Wang, Xu Zhu, Lin Dang, Hongmei Jiang, Ying Xie, Xin Li, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 4) Peer-Reviewed

  Feb. 15, 20229,256 words Report 1450LThe chromosomal t(4;14)(p16;q32) translocation drives high expression of histone methyltransferase nuclear SET domaincontaining 2 (NSD2) and plays vital roles in multiple myeloma (MM) evolution and progression. However,...