Search Results

• • 27 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.

  Authors:Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly M. Ly, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,858 words Report 1420LAnti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously...

• Endothelial Piezol sustains muscle capillary density and contributes to physical activity.

  Authors:Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202210,443 words Report 1380LPiezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial...

• Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.

  Authors:Wenxin Song, Anne P. Beigneux, Anne-Marie L. Winther, Kristian K. Kristensen, Anne L. Gronnemose, Ye Yang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,220 words Report 1380LGPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the...

• JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.

  Authors:Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,848 words Report 1460LObstructive arterial diseases, including supravalvular aortic stenosis (SVAS), atherosclerosis, and restenosis, share 2 important features: an abnormal or disrupted elastic lamellae structure and excessive smooth muscle...

• Fungal microbiome in inflammatory bowel disease: a critical assessment.

  Authors:David M. Underhill and Jonathan BraunFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20228,602 words Report 1390LThe gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and disease activity. While this has mainly been studied in the context of the bacterial microbiome, recent advances have provided...

• Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure.

  Authors:Sharlene M. Day, Jil C. Tardiff, and E. Michael OstapFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20227,500 words Report 1490LMyosin modulators are a novel class of pharmaceutical agents that are being developed to treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to target cardiac myosins directly to...

• Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections.

  Authors:Colin J. Worby, Benjamin S. Olson, Karen W. Dodson, Ashlee M. Earl, and Scott J. HultgrenFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20222,583 words Article 1380LIntroduction The widespread use of antibiotics, in both healthcare and agriculture, has led to the emergence of antibiotic-resistant bacteria, decreasing our ability to effectively treat common infections. With...

• LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation.

  Authors:Jamie A. Moore, Jayna J. Mistry, Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202210,895 words Report 1320LThe bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for...

• Boosting [NAD.sup.+] blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.

  Authors:Jing Wu, Komudi Singh, Amy Lin, Allison M. Meadows, Kaiyuan Wu, Vivian Shing, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202210,560 words Report 1430LBACKGROUND. Fasting and [NAD.sup.+]-boosting compounds, including [NAD.sup.+] precursor nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying mechanisms and therapeutic potential are...

• Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers.

  Authors:Shixiang Sun, Kristina Brazhnik, Moonsook Lee, Alexander Y. Maslov, Yi Zhang, Zhenqiu Huang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20223,973 words Report 1520LInherited germline mutations in the breast cancer gene 1 (BRCA1) or BRCA2 genes (herein BRCA1/2) greatly increase the risk of breast and ovarian cancer, presumably by elevating somatic mutational errors as a consequence...

• Concerns over functional experiments, interpretation, and required controls.

  Authors:Eddie C.Y. Wang, Ceri A. Fielding, and Richard J. StantonFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 2022613 words Letter to the editor 1170LTo the Editor: Hsieh et al. (1) provide comprehensive data correlating NK phenotypes with SARS-CoV-2 clearance. However, the functional experiments provided to support their mechanistic conclusions are far from...

• RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.

  Authors:Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,858 words Report 1600LDespite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases,...

• Therapeutic targets for cardiac fibrosis: from old school to next-gen.

  Authors:Joshua G. Travers, Charles A. Tharp, Marcello Rubino, and Timothy A. McKinseyFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20229,502 words Report 1550LCardiovascular diseases remain the leading cause of death worldwide, with pathological fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying theme across etiologies. Despite the...

• Concerns over functional experiments, interpretation, and required controls. Reply.

  Authors:Wan-Chen Hsieh and Shih-Yu ChenFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 2022656 words Letter to the editor 1370LThe author's reply: We thank Dr. Stanton, Dr. Fielding, and Dr. Wang for their careful reading of our manuscript, especially for their comments on the alterations of the cell surface by SARS-CoV-2 and how these...

• ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine.

  Authors:Jun Xu, Sek Man Su, Xin Zhang, Un In Chan, Ragini Adhav, Xiaodong Shu, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,807 words Report 1640LCancer metastasis is the cause of the majority of cancer-related deaths. In this study, we demonstrated that no expression or low expression of ATP11B in conjunction with high expression of PTDSS2, which was negatively...

• The hematopoietic saga of clonality in sickle cell disease.

  Authors:Aaron J. Stonestrom and Ross L. LevineFrom:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20222,179 words Article 1430LSickle cell disease (SCD) is associated with an increased risk of vascular-occlusive events and of leukemia. Clonal hematopoiesis (CH) may increase both risks. In turn, physiologic abnormalities in SCD may modify the...

• USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Ap generation.

  Authors:Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20226,820 words Report 1320LDown syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer's disease (AD), implicating key roles for chromosome 21-encoded genes in the pathogenesis of AD. We previously identified a...

• Alterations in auditory brain stem response distinguish occasional and constant tinnitus.

  Authors:Niklas K. Edvall, Golbarg Mehraei, Martin Claeson, Andra Lazar, Jan Bulla, Constanze Leineweber, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 20227,280 words Report 1450LBACKGROUND. The heterogeneity of tinnitus is thought to underlie the lack of objective diagnostic measures. METHODS. Longitudinal data from 20,349 participants of the Swedish Longitudinal Occupational Survey of Health...

• SIRP[gamma]-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.

  Authors:Chuan Xu, Guoxiang Jin, Hong Wu, Wei Cui, Yu-Hui Wang, Rajesh Kumar Manne, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202210,368 words Report 1530LCancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade immune cell killing and promote tumor progression. Here we showed that signal regulatory protein [gamma] (SIRP[gamma]) determined CSLC...

• Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.

  Authors:Rita C. Andersen, Jan H. Schmidt, Joscha Rombach, Matthew D. Lycas, Nikolaj R. Christensen, Viktor K. Lund, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 5) Peer-Reviewed

  Mar. 1, 202211,499 words Report 1530LBin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the...